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The p70 S6 Kinase Integrates Nutrient and Growth Signals to Control Translational Capacity

  • Chapter
Signaling Pathways for Translation

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 26))

Abstract

The p70 S6 kinase was one of the first insulin/mitogen activated protein (Ser/Thr) kinases to be described. The kinase was purified to homogeneity over a decade ago, its molecular structure defined and the enzymology of its phosphorylation of the 40 S subunit protein S6 well worked out, both in vitro and in vivo. By contrast, the cellular function of the kinase, the mechanisms of activation and the nature of the signal transduction elements upstream have been elucidated only within the last several years. This review will describe our current understanding of the biologic role of the p70 kinase as gleaned from experiments in mammalian cell culture, and through gene deletion in mouse and Drosophila, as well as the regulation of the p70 kinase and the nature of the signal transduction pathways that funnel into the control of this ubiquitous signal-responsive ribosomal protein kinase

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Authors and Affiliations

  1. Diabetes Unit and Medical Services, and the Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, 02114, USA

    Joseph Avruch, Christopher Belham & Qing-Peng Weng

  2. Department of Medicine, Harvard Medical School, Boston, Massachusetts, 02114, USA

    Joseph Avruch, Christopher Belham & Qing-Peng Weng

  3. Biosignal Research Center, Kobe University, Kobe City, Japan

    Kenta Hara & Kazuyoshi Yonezawa

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  1. Joseph Avruch
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  2. Christopher Belham
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  3. Qing-Peng Weng
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  4. Kenta Hara
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  5. Kazuyoshi Yonezawa
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  1. Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA, 71130, USA

    Robert E. Rhoads

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Avruch, J., Belham, C., Weng, QP., Hara, K., Yonezawa, K. (2001). The p70 S6 Kinase Integrates Nutrient and Growth Signals to Control Translational Capacity. In: Rhoads, R.E. (eds) Signaling Pathways for Translation. Progress in Molecular and Subcellular Biology, vol 26. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56688-2_5

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