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Boron Neutron Capture Therapy: Application of Radiobiological Principles

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Neutron Capture Therapy

Abstract

The radiobiological characteristics of the different dose components of BNCT exposure are examined. Dose-rate determines the biological effectiveness of γ-rays, due to the capacity of cells to repair DNA damage from this low-LET radiation. Photon dose-rate has been largely overlooked in the application of BNCT. Recoil protons vary in their relative biological effectiveness (RBE) as a function of neutron energy and tissue endpoint. Thus the energy spectrum of a beam will influence the RBE of this component of the dose. Protons, of the energy produced by nitrogen capture, have not been studied. In practice protons from nitrogen capture have been combined with the recoil proton contribution into a total neutron dose. The relative biological effectiveness of the products of the boron capture reaction are a composite of the RBE of the short range products and the biodistribution of the boron, referred to collectively as the compound biological effectiveness (CBE) factor. The caution needed in the application of these factors for different normal tissues and tumors is discussed.

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Authors and Affiliations

  1. Particle Therapy Cancer Research Institute and Green Templeton College, University of Oxford, Oxford, UK

    John W. Hopewell

  2. Medical Department, Brookhaven National Laboratory, Upton, NY, USA

    Gerard M. Morris

  3. Department of Radiobiology, Constituyentes Atomic Center, National Atomic Energy Commission, San Martín, Buenos Aires, Argentina

    Amanda E. Schwint

  4. Ora Inc., 300 Brickstone Square, Andover, MA, USA

    Jeffrey A. Coderre

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Correspondence to John W. Hopewell .

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Editors and Affiliations

  1. Zentrum für Konservative Onkologie, Klinik für Strahlentherapie, Univ.Klinikum Essen, Hufelandstr. 55, Essen, 45122, Germany

    Wolfgang Sauerwein

  2. Philipps-University Marburg, Department of Radiation Oncology, University Hospital Marburg,, Baldingerstrasse 1, Marburg, 35043, Germany

    Andrea Wittig

  3. Joint Research Centre, Institute for Engergy, European Commission, Westerduinweg 3, LE Petten, 1755, Netherlands

    Raymond Moss

  4. , Department of Neurosurgery, Kagawa National Children's Hospital, Zentsuji-cho 2603, Zentsuji, 765-8501, Kagawa, Japan

    Yoshinobu Nakagawa

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Hopewell, J.W., Morris, G.M., Schwint, A.E., Coderre, J.A. (2012). Boron Neutron Capture Therapy: Application of Radiobiological Principles. In: Sauerwein, W., Wittig, A., Moss, R., Nakagawa, Y. (eds) Neutron Capture Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-31334-9_17

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