Abstract
Oral mucositis is a frequent side effect during conventional radiotherapy for advanced head and neck tumours. While acute radiation damage to the oral mucosa is not a problem for the majority of glioma patients involved in the current boron neutron capture therapy (BNCT) clinical trial at BNL, a subset of patients with tumours located towards the front of the brain are presenting with transient acute effects in the oral mucosa. This suggests that the oral mucosa could become a potential dose limiting tissue in future treatment protocols involving higher doses and larger irradiation field sizes. The objective of the present study was to evaluate dose-effect relationships and estimate relative biological effectiveness (RBE) and compound biological effectiveness (CBE) factors for this critical normal tissue. The model selected for study was rat ventral tongue mucosa. Ventral tongue offers the most readily accessible area of representative multi-layered oral epithelium. It can be locally irradiated (and readily scored), greatly reducing the radiation burden to the head.
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Morris, G.M., Coderre, J.A., Smith, D.R., Hopewell, J.W. (2001). A Rat Model of Oral Mucosal Response to Boron Neutron Capture Irradiation. In: Hawthorne, M.F., Shelly, K., Wiersema, R.J. (eds) Frontiers in Neutron Capture Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1285-1_194
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DOI: https://doi.org/10.1007/978-1-4615-1285-1_194
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