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Molecular Phylogenetics of Restriction Endonucleases

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Restriction Endonucleases

Part of the book series: Nucleic Acids and Molecular Biology ((NUCLEIC,volume 14))

Abstract

The phenomenon of restriction and modification (R-M) was first discovered in the early 1950s. It was observed that certain strains of bacteria inhibited (‘restricted’) the growth of bacteriophages previously propagated on a different strain. In the early 1960s, it was found that the restriction is due to the enzymatic cleavage of the phage DNA by sequence -specific endonucleases (REases), which are sensitive to covalent modification of bases in the target sequence. Some of the REases produced discrete DNAfragments upon cleavage. This property proved very useful for analyzing and rearranging DNA, which soon prompted the rapid development of genetic engineering techniques as well as the search for more REaseswith novel recognition sequences (early review: Arber and Linn 1969). It was in the mid-1970s when cloning of R-M enzymes themselves began (review by Lunnen et al. 1988). It was found that most of restriction enzymes are genetically linked with modification enzymes of cognate specificity, forming R-M systems, but a few solitary enzymes were also characterized (reviews: Wilson 1991; Wilson and Murray 199I).

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Authors and Affiliations

  1. Bioinformatics Laboratory, International Institute of Molecular and Cell Biology in Warsaw, Trojdena 4, 02-109, Warsaw, Poland

    J. M. Bujnicki

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  1. J. M. Bujnicki
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  1. Institute for Biochemistry, Justus-Liebig-University, Heinrich-Buff-Ring 58, 35392, Giessen, Germany

    Alfred M. Pingoud

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© 2004 Springer-Verlag Berlin Heidelberg

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Bujnicki, J.M. (2004). Molecular Phylogenetics of Restriction Endonucleases. In: Pingoud, A.M. (eds) Restriction Endonucleases. Nucleic Acids and Molecular Biology, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18851-0_3

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  • DOI: https://doi.org/10.1007/978-3-642-18851-0_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62324-0

  • Online ISBN: 978-3-642-18851-0

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