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Role of Zinc Finger Transcription Factor Zfp69 in Body Fat Storage and Diabetes Susceptibility of Mice

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Sensory and Metabolic Control of Energy Balance

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 52))

Abstract

Type 2 diabetes is a polygenic disease resulting from a combination of different disease alleles reflecting obesity, insulin resistance, and hyperglycemia. Using a positional cloning strategy with different inbred strains of mice, we mapped a disease locus for obesity-associated diabetes on chromosome 4. We analyzed all genes in this region and identified distinct differences in the expression levels of the transcription factor Zfp69. The expression of this gene mediated diabetes progression in a leptin-deficient congenic mouse line. The animals developed a disease pattern of hyperglycemia, reduced gonadal fat mass, and increased plasma and liver triglycerides, resembling a potential defect in triglyceride storage . In order to elucidate the impact of the human ortholog of Zfp69 in the development of type 2 diabetes, we tested its mRNA expression in human white adipose tissue. Consistent with the mouse data, mRNA-expression was significantly higher in diabetic subjects than in unaffected controls.

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Authors and Affiliations

  1. German Institute of Human Nutrition Potsdam-Rehbrücke, Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany

    Stephan Scherneck, Heike Vogel, Matthias Nestler, Reinhart Kluge, Annette Schürmann & Hans-Georg Joost

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  1. Stephan Scherneck
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  2. Heike Vogel
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  3. Matthias Nestler
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  4. Reinhart Kluge
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  5. Annette Schürmann
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  6. Hans-Georg Joost
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Correspondence to Stephan Scherneck .

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Editors and Affiliations

  1. Potsdam-Rehbrücke (DIFE), Abt. Molekulare Genetik, Deutsches Institut für Ernährungsforschu, Arthur-Scheunert-Allee 114-116, Nuthetal, 14558, Brandenburg, Germany

    Wolfgang Meyerhof

  2. Martinistr. 52, Hamburg, 20246, Germany

    Ulrike Beisiegel

  3. German Institute of Human Nutrition Pots, Arthur-Scheunert-Allee 114-116, Nuthetal, 14558, Germany

    Hans-Georg Joost

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Scherneck, S., Vogel, H., Nestler, M., Kluge, R., Schürmann, A., Joost, HG. (2011). Role of Zinc Finger Transcription Factor Zfp69 in Body Fat Storage and Diabetes Susceptibility of Mice. In: Meyerhof, W., Beisiegel, U., Joost, HG. (eds) Sensory and Metabolic Control of Energy Balance. Results and Problems in Cell Differentiation, vol 52. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-14426-4_6

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