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Muscular Dystrophies and Myopathies in Arab Populations

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Genetic Disorders Among Arab Populations

Abstract

Interest in neuromuscular disorders has grown rapidly in recent years as knowledge of their molecular basis has advanced and the search for potential treatment by gene or cell therapy has begun. (Allamand et al. 2000; Cordier et al. 2000; Dressman et al. 2002; Yakota et al. 2009). This chapter gives an overview of the epidemiologic, clinical, and laboratory studies of muscular dystrophies (MDs) and myopathies reported in Arab communities.

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References

  • Abba AA (2006) Mitochondrial encephalomyopathy presenting with respiratory failure in an adult. J Med Sci 6:704–708

    Article  Google Scholar 

  • Aberfeld DC, Hinterbuchner LP, Schneider M (1965) Myotonia, dwarfism, diffuse bone disease and unusual ocular and facial abnormalities (a new syndrome). Brain 88:1313–1321

    Article  Google Scholar 

  • Abu-Amero KK, Ozand PT, Al-Dhalaan H (2006) Novel mitochondrial DNA transversion mutation in transfer ribonucleic acid for leucine 2 (CUN) in a patient with the clinical features of MELAS. J Child Neurol 21:971–972

    Article  PubMed  Google Scholar 

  • Al-Gazali LI (1993) The Schwartz-Jampel syndrome. Clin Dysmorphol 2:47–54

    PubMed  CAS  Google Scholar 

  • Al-Gazali LI, Varghese M, Varady E, Al Talabin J, Scorer J, Bakalinova D (1996) Neonatal Schwartz-Jampel syndrome in the United Arab Emirates. J Med Genet 33:203–211

    Article  PubMed  CAS  Google Scholar 

  • Al-Gazali LI, Ravenscroft A, Feng A, Shubbar A, Al-Saggaf A, Haas D (2003) Stuve-Wiedemann syndrome in children surving infancy: clinical and radiological features. Clin Dysmorphol 12:1–8

    Article  PubMed  CAS  Google Scholar 

  • Al-Husain MA, Al-Eissa YA, Al-Sohaibani MO, Al-Omair AO, Al-Nasser MN (1994) Schwartz-Jampel syndrome in Saudi children. Ann Saudi Med 14:152–156

    PubMed  CAS  Google Scholar 

  • Al-Jumah M, Majumdar R, Al-Rajeh S, Chaves-Carballo E, Salih MM, Awada A, Al-Shahwan S, Al-Uthaim S (2002) Deletion mutations in the dystrophin gene of Saudi patients with Duchenne and Becker muscular dystrophy. Suadi Med J 23:1478–1482

    Google Scholar 

  • Allamand V, Sunada Y, Salih MA, Straub V, Ozo CO, Al-Turaiki MH, Akbar M, Kolo T, Colognato H, Zhang X et al (1997) Mild congenital muscular dystrophy in two patients with an internally deleted laminin alpha2-chain. Hum Mol Genet 6:747–752

    Article  PubMed  CAS  Google Scholar 

  • Allamand V, Donahue KM, Straub V, Davisson RL, Davidson BL, Campbell KP (2000) Early adenovirus-mediated gene transfer effectively prevents muscular dystrophy in alpha-sarcoglycan-deficient mice. Gene Ther 16:1385–1391

    Article  CAS  Google Scholar 

  • Al-Qudah AA, Kobayashi J, Chuang S, Dennis M, Ray P (1990) Etiology of intellectual impairment in Duchenne muscular dystrophy. Pediatr Neurol 6:57–59

    Article  PubMed  CAS  Google Scholar 

  • Al-Qudah AA, Tarawneh M (1998) Congenital muscular dystrophy in Jordanian children. J Child Neurol 13:383–386

    Article  PubMed  CAS  Google Scholar 

  • Al-Rajeh S, Bademosi O, Ismail H, Awada A, Dawodu A, Al-Freihi H, Assuhaime S, Borollosi M, Al-Shammasi S (1993) A community survey of neurological disorders in Saudi Arabia: the Thugban study. Neuroepidemiology 12:164–178

    Article  PubMed  CAS  Google Scholar 

  • Aoki M, Lui J, Richard I, Bashir R, Britton S, Keers SM, Oeltjen J, Brown HEV, Marchand S, Bourg N et al (2001) Genomic organization of the dysferlin gene and novel mutations in Miyoshi myopathy. Neurology 57:271–278

    Article  PubMed  CAS  Google Scholar 

  • Armstrong ML (1985) Electrocardiograms. A systemic method of reading them. Wright, Bristol

    Google Scholar 

  • Azibi K, Chaouch M, Reghis A, Vinet MC, Vignal A, Becuwe N, Beckmann JC, Seboun E, Nguyen S, Cometto M, Fardeau M, Tome F, Leturcq F, Chafey P, Bachner L, Kaplan JC (1991) Linkage analysis of 19 families with autosomal recessive (Duchenne-like) muscular dystrophy from Algeria. Cytogenet Cell Genet 58:1907

    Article  Google Scholar 

  • Azibi K, Bachner L, Beckman JS, Matsumara K, Hamouda E, Chaouch M, Chaouch A, Ait-Quarab R, Vignal A, Weissenbach J, Vinet M-C, Leturcq F, Collin H, Tome FMS, Reghis A, Fardeau M, Kampbell KP, Kaplan JC (1993) Severe childhood autosomal recessive muscular dystrophy with the deficiency of 50 kDA dystrophin-associated glycoprotein maps to chromosome 13q12. Hum Mol Genet 2:1423–1428

    Article  PubMed  CAS  Google Scholar 

  • Barresi R, Michele DE, Kanagawa M, Harper HA, Dovico SA, Satz JS, Moore SA, Zhang W, Schachter M, Dumanski JP (2004) LARGE can functionally bypass alpha-dystroglycan glycosylation defects in distinct congenital muscular dystrophies. Nat Med 10:696–703

    Article  PubMed  CAS  Google Scholar 

  • Barrientos A, Barros MH, Valnot I, Rotig A, Rustin P, Tzagaloff A (2002) Cytochrome oxidase in health and disease. Gene 286:53–63

    Article  PubMed  CAS  Google Scholar 

  • Bashir R, Strachan T, Keers S, Stephenson A, Mahjneh I, Marcone G, Nashef L, Nushby KMD (1994) A gene for autosomal recessive limb girdle muscular dystrophy maps to chromosome 2p. Hum Mol Genet 3:455–457

    Article  PubMed  CAS  Google Scholar 

  • Ben Hamida M, Fardeau M (1980) Severe autosomal recessive limb-girdle muscular dystrophies frequent in Tunisia. In: Angelini C, Danieli GA, Fontanari D (eds) Muscular dystrophy research: advances and new trends. Excerpta Medica, Amsterdam, pp 143–146

    Google Scholar 

  • Ben Hamida M, Hentati F (1989) Tunisian severe childhood muscular dystrophy: a normal spinal cord and anterior horn neurons. Muscle Nerve 12:156

    Article  PubMed  CAS  Google Scholar 

  • Ben Hamida M, Ben Hamida C, Zouari M, Belal S, Hentati F (1996) Limb-girldle muscular dystrophy 2C: clinical aspects. Neuromuscul Disord 6:493–494

    Article  PubMed  CAS  Google Scholar 

  • Ben Jelloun-Dellagi S, Chaffey P, Hentati F, Ben-Hamida C, Tome FMS, Collin H, Dellagi K, Kaplan J-C, Fardeau M, Benm Hamida M (1990) Presence of normal dystrophin in Tunisian severe childhood autosomal recessive muscular dystrophy. Neurology 40:1903

    Article  PubMed  CAS  Google Scholar 

  • Ben Othmane K, Ben Hamida M, Pericak-Vance M, Ben Hamida C, Blel S, Carte SC, Bowcock AM, Pertruhkin K, Gilliam TC, Roses AD (1992) Linkage of Tunisian autosomal recessive Duchnne-like muscular dystrophy to the pericentromeric region of chromosome 13q. Nat Genet 2:315–317

    Article  PubMed  CAS  Google Scholar 

  • Ben Othmane K, Speer MC, Stauffer S, Blel S, Middleton L, Ben Hamida C, Etribi A, Loeb D, Hentati F, Roses AD et al (1995) Evidence of linkage disequilibrium in chromosome 13-linked Duchenne-like muscular dystrophy (LGMD2C). Am J Hum Genet 57:732–734

    PubMed  CAS  Google Scholar 

  • Ben-Hamida M, Marrakchi D (1980a) Etude genetique des myopathies en Tunisie. Tire a part de I’Union Medical 109:1–8

    Google Scholar 

  • Ben-Hamida M, Marrakchi D (1980b) Dystrophie musculaire progressive de type Duchenne et Tunisie: a propos de 13 families et 31 cas d’une forme en apparence recessive autosomique. J Genet Hum 28:1–9

    PubMed  CAS  Google Scholar 

  • Ben-Hamida M, Fardeau M, Attia N (1983) Severe childhood muscular dystrophy affecting both sexes and frequent in Tunisia. Muscle Nerve 6:469–480

    Article  PubMed  CAS  Google Scholar 

  • Berenberg RA, Pellock JM, DiMauro S, Schotand DL, Bonilla E, Eastwood A, Hays A, Vicale CT, Sehrens M, Chutorian A, Rowland LP (1977) Lumping or splitting? “Ophthalmoplegia plus” or Kearns-Sayre syndrome? Ann Neurol 1:37–54

    Article  PubMed  CAS  Google Scholar 

  • Bernier FP, Boneh A, Dennet X, Chow CW, Cleary MA, Thornbum DA (2002) Diagnostic criteria for respiratory chain disorders in adults and children. Neurology 59:1406–1411

    Article  PubMed  CAS  Google Scholar 

  • Bessiso MS, Teebi AS, Al-Awadi SA, Al-Rashied AA (1986) Schwartz-Jamp syndrome. A case study and electromyographic finding. J Kuwait Med Assoc 20:195–199

    Google Scholar 

  • Billard C, Gillet P, Signoret JL, Uicaut E, Bertrand P, Fardeau M, Sartho Carpentier MA, Santini JI (1992) Cognitive functions in Duchenne muscular dystrophy: a reappraisal and comparison with spinal muscular atrophy. Neuromuscul Disord 2:371–378

    Article  PubMed  CAS  Google Scholar 

  • Bohlega SA, Cook J, Haider A, Al-Kawi MZ, Sitgsby B (1992) Childhood autosomal recessive muscular dystrophy: a study of Saudi family. Ann Saudi Med 12:600 [Abstract]

    Google Scholar 

  • Bohlega S, Al-Kawi MZ, Chavis P, Haider A, Omer S (1993) Mitochondrial DNA deletion in Kearns-Sayre syndrome: a review and illustrating cases. Ann Saudi Med 13:197–202

    PubMed  CAS  Google Scholar 

  • Bohlega S, Tanji K, Santorelli FM, Hirano M, Al-Jishi A, DiMauro S (1996) Multiple mitochondrial DNA deletions associated with autosomal recessive ophthalmoplegia and severe cardiomyopathy. Neurology 46:1329–1334

    Article  PubMed  CAS  Google Scholar 

  • Bonnemann CG, Modi R, Noguchi S, Mizuno Y, Yoshida M, Gussoni E, McNally EM, Duggan DJ, Angelini C, Hoffman EP (1995) Beta-sarcoglycan (A3b) mutations cause autosomal recessive muscular dystrophy with loss of sarcoglycan complex. Nat Genet 1995:266–273

    Article  Google Scholar 

  • Bonnemann CG, Wong J, Ben Hamida C, Hamida MB, Hentati F, Kunkel LM (1998) LGMD 2E in Tunisia is caused by a homozygous missence mutation in beta-sarcolgycan exon 3. Neuromuscul Disord 8:193–197

    Article  PubMed  CAS  Google Scholar 

  • Brown KA, Al-Gazali LI, Moynihan LM, Lench NJ, Markham AF, Mueller RF (1997) Genetic heterogeneity in Schwartz-Jampel syndrome: two families with neonatal Schwartz-Jampel syndrome do not map to human chromosome 1p34-p36.1. J Med Genet 54:685–687

    Article  Google Scholar 

  • Bushby KMD (1999) Making sense of the limb-girdle muscular dystrophies. Brain 122:1403–1420

    Article  PubMed  Google Scholar 

  • Bushby KMD, Beckmann JS (1995) Diagnostic criteria for the limb-girdle muscular dystrophies: report of the ENMC workshop on limb-girdle muscular dystrophies. Neuromuscul Disord 5:71–74

    Article  PubMed  CAS  Google Scholar 

  • Campbell K, Allamand V, Sunada Y, Straub V, Salih M (2000) Method for aiding in the diagnosis of in-frame deletion type congenital muscular dystrophy. US Patent 6,136,546. http://www.freepatentsonline.com/6136546.html

  • Cardomone M, Darras BT, Ryan MM (2008) Inherited myopathies and muscular dystrophies. Semin Neurol 28:250–259

    Article  Google Scholar 

  • Carmignac V, Salih MAM, Quijano-Roy S, Marchand S, Marchand S, Al Rayess MM, Mukhtar MM, Ja U, Labeit S, Guicheney P et al (2007) G terminal titin deletions cause a novel early-onset myopathy with fatal cardiomyopathy. Ann Neurol 61:340–351

    Article  PubMed  CAS  Google Scholar 

  • Chaudhary AG, Alqahtani MH, Abusenadah A, Gari M, Al-Sofyani AA, Al-Aama JY, Lary SA, Elaimi AH (2008) Mutation analysis in Saudi Duchenne and Becker muscular dystrophy patients using multiplex PCR. Arch Med Sci 4:16–21

    CAS  Google Scholar 

  • Cook JD, Gascon GG, Haider A, Coates R, Stigbsby B, Ozand PT, Banna M (1992) Congenital muscular dystrophy with abnormal radiographic myelin pattern. J Child Neurol 7(Suppl):S51–S63

    Google Scholar 

  • Cordier L, Hack AA, Scott MO et al (2000) Rescue of skeletal muscles of gamma-sarcoglycan-deficient mice with adeno-associated virus-mediated gene transfer. Mol Ther 1(2):119–129

    Article  PubMed  CAS  Google Scholar 

  • Cupler EJ, Bohlega S, Hesslen R, McLean d, Stigsby B, Ahmad J (1998) Miyoshi myopathy in Saudi Arabia: clinical, electrophysiological, histopathological and radiological features. Neuromuscul Disord 8:321–326

    Article  PubMed  CAS  Google Scholar 

  • Dagoneau N, Scheffer D, Huber C, Al-Gazali LI, Di Rocco M, Godard A, Martinovic J, Raas-Rothschild A, Sigaudy S, Unger S (2004) Null leukemia inhibitory factor receptor (LIFR) mutations in Stuve-Wiedemann/Schwartz-Jampel type 2 syndrome. Am J Hum Genet 74:298–306

    Article  PubMed  CAS  Google Scholar 

  • DiMauro S (1993) Mitochondrial disorders. In: Rosenberg RN, Prusiner SB, Di Mauro S, Barchi RL, Kunkel LM (eds) Molecular and genetic basis of neurological disease. Butterwoth-Heinemann, Boston, pp 665–694

    Google Scholar 

  • DiMauro S, Bonilla E, Mancuso M, Filosto M, Sacconi S, Salviati L, Hirano M (2004) Mitochondrial myopathies. Basic Appl Myol 13:145–155

    Google Scholar 

  • Dobyns WB, Pagon RA, Armstrong d, Curry CJR, Greenberg F, Grix A, Holmes LB, Laxova R, Michels W, Robinow M, Zimmerman RL (1989) Diagnostic criteria for Walker-Warburg syndrome. Am J Med Genet 32:195–210

    Article  PubMed  CAS  Google Scholar 

  • Dressman D, Araishi K, Imamura M, Sasaoka T, Liue LA, Engvall E, Hoffman EP (2002) Delivery of alpha- and beta-sarcoglycan by recombinant adeno-associated virus: efficient rescue of muscle, but differential toxicity. Hum Gene Ther 13:1631–1646

    Article  PubMed  CAS  Google Scholar 

  • Driss A, Amari R, Ben Hamida C, Souilem S, Govider-Khorija N, Ben Hamida M, Hentati F (2000) A new locus of autosomal recessive limb-girdle muscular dystrophy in a large consanguineous Tunisian family maps to chromosome 19q13.3. Neuromuscul Disord 10:240–246

    Article  PubMed  CAS  Google Scholar 

  • Dubowitz V (1980) Rapidly progressive limb girdle muscular dystrophy in childhood. In: Angelini D, Danieli GA, Fontanari D (eds) Muscular dystrophy research: advances and new trends. Exceprta Medica, Amsterdam, pp 129–133

    Google Scholar 

  • Dubowitz V (1994) Workshop report: 22nd ENMC sponsored workshop on congenital muscular dystrophy held in Baarn, The Netherlands, 14–16 May 1993. Neuromuscul Disord 4:75–81

    Article  PubMed  CAS  Google Scholar 

  • Effat LK, El-Harouni AA, Amr KS, El-Minisi TI, Abdel Meguid N, El-Awady M (2000) Screening of dystrophin gene deletions in Egyptian patients with DMD/BMC muscular dystrophies. Dis Markers 16:125–129

    PubMed  CAS  Google Scholar 

  • Effat LK, Amr KS, El-Horouni AA, Gaber KR (2008) The impact of prenatal diagnosis in Egyptian families with Duchenne muscular dystrophy. Egypt J Med Hum Genet 9:105–110

    Google Scholar 

  • Egger J, Lake BD, Wilson J (1981) Mitochondrial cytopathy: a multisystem disorder with ragged red fibres on muscle biopsy. Arch Dis Child 56:741–752

    Article  PubMed  CAS  Google Scholar 

  • El Kerch F, Sefiani A, Azibi K, Boutaleb N, Yahyaoui M, Bentahila A, Vinet M-C, Leturcq F, Bachner L, Beckmann J, Campbell KP, Tome FMS, Fardeau M, Kaplan J-C (1994) Linkage analysis of families with severe childhood autosomal recessive muscular dystrophy in Morocco indicates genetic homogeneity of the disease in North Africa. J Med Genet 31:342–343

    Article  PubMed  CAS  Google Scholar 

  • El-Harouni AA, Amr KS, Effat LK, Easawi ML, Ismail S, Gad YZ, E-Awady MK (2003) The milder phenotype of the dystrophin gene double deletions. Acta Neurol Scand 107:400–404

    Article  PubMed  CAS  Google Scholar 

  • El-Menyar AA, Al-Suwaidi J, Gehani AA, Bener A (2004) Clinical and histologic studies of a Qatani family with myofibrillar myopathy. Saudi Med J 25:1723–1726

    PubMed  Google Scholar 

  • El-Menyar AA, Bener A, Numan MT, Morcos S, Taha RY, Al-Suwaidi J (2006) Epidemiology of idiopathic cardiomyopathy in Qatar during 1996-2003. Med Princ Pract 15:56–61

    Article  PubMed  Google Scholar 

  • Emery AEH (1987) Duchenne muscular dystrophy. Oxford University Press, New York

    Google Scholar 

  • Emery AEH (1991) Population frequencies of inherited neuromuscular diseases- a world survey. Neuromuscul Disord 1:19–29

    Article  PubMed  CAS  Google Scholar 

  • Ervasti JM, Campbell KP (1991) Membrane organization of the dystrophin-glycoprotein complex. Cell 66:1121–1131

    Article  PubMed  CAS  Google Scholar 

  • Farag TI, Teebi AS (1990) Duchenne-like muscular dystrophy in the Arabs. Am J Med Genet 37:290

    Article  Google Scholar 

  • Farag TI, Rao VK, El-Khalifa MY, Sundareshan TS, Marafie JM, Voncina D, Simsek M, Mady SA, Al-Othman SA, Al-Awadi SA (1989) Autosomal recessive Duchenne-like muscular dystrophy in Arabs: report of a Kuwaiti family and literature review. Med Princ Pract 1:96–101

    Article  Google Scholar 

  • Fardeau M, Matsumura K, Tome FMS, Collin LH, Leturcq F, Kaplan J-C, Campbell KP (1993) Deficiency of the 50 kDa dystrophin-associated glycoprotein (adhalin) in severe autosomal recessive muscular dystrophy in children native from European countries. C R Acad Sci Paris III 316:799–804

    CAS  Google Scholar 

  • Fariello R, Meloff K, Murphy EG, Reilly B, Armstrong D (1978) A case of Schwartz-Jampel syndrome with unusual muscle biopsy finding. Ann Neurol 3:93–96

    Article  PubMed  CAS  Google Scholar 

  • Fendri K, Kefi M, Hentati F, Amouri R (2006) Genetic heterogeneity within a consanguineous family involving the LGMD 2D and the LGMD 2C genes. Neuromuscul Disord 16:316–320

    Article  PubMed  CAS  Google Scholar 

  • Ferrannini E, Perniola T, Krajewska G, Serlenga L, Trizio M (1982) Schwartz-Jampel syndrome with autosomal-dominant inheritance. Eur Neurol 21:137–146

    Article  PubMed  CAS  Google Scholar 

  • Fukuyama Y, Osama M, Suzuki H (1981) Congenital progressive muscular dystrophy of the Fukuyama type: clinical, genetic and pathological considerations. Brain Dev 3:1–29

    Article  PubMed  CAS  Google Scholar 

  • Fukuzawa A, Lange S, Holt M, Vichola A, Carmignac V, Ferreiro A, Udd B, Gautel M (2008) Interchains with titin and myomesin target obscuring and obscuring-like 1 to the M-band-implication for hereditary myopathies. J Cell Sci 121:1841–1851

    Article  PubMed  CAS  Google Scholar 

  • Gardner-Medwin D, Johnston HM (1984) Severe muscular dystrophy in girls. J Neurol Sci 64:79–87

    Article  PubMed  CAS  Google Scholar 

  • Gardner-Medwin D, Sharples P (1989) Some studies of the Duchenne and autosomal recessive types of muscular dystrophy. Brain Dev 11:91–97

    Article  PubMed  CAS  Google Scholar 

  • Giedion A, Boltshauser E, Briner J, Eich G, Exner G, Fendel H, Kaufmann L, Steinmann B, Spranger J, Superti-Furga A (1997) Heterogeneity in Schwartz-Jampel chondrodystrophic myotonia. Eur J Pediatr 156:214–223

    Article  PubMed  CAS  Google Scholar 

  • Grewal PK, Holzfeind PJ, Bittner RE, Hewitt JE (2001) Mutant glycosyltransferase and altered glycosylation of alpha-dystroglycan in the myodystrophy mouse. Nat Genet 28:151–154

    Article  PubMed  CAS  Google Scholar 

  • Haider MZ, Bastaki L, Habib Y, Moosa A (1998) Screening 25 dystrophin gene exons for deletions in Arab children with Duchenne muscular dystrophy. Hum Hered 48:61–66

    Article  PubMed  CAS  Google Scholar 

  • Helliwell TR, Nguyen thi Man, Morris GE, Davies KE (1992) The dystrophin-related protein, utrophin, is expressed in the sarcolemma of regenerating human skeletal muscle fibres in dystrophies and inflammatory myopathies. Neuromuscul Disord 2:177–184

    Google Scholar 

  • Hoffman EP, Brown RH, Kunkel LM (1987) Dystrophin: the protein product of the Duchenne muscular dystrophy locus. Cell 51:919–928

    Article  PubMed  CAS  Google Scholar 

  • Hoffman EP, Fischbeck KH, Brown RH, Johnson M, Medori R, Loike JD, Harris JB, Waterson R, Brook M, Specht L, Kupsky W, Chamberlain J, Caskey T, Shapiro F, Kunkel LM (1988) Characterization of dystrophin in muscle-biopsy specimens from patients with Duchenne’s or Becker’s muscular dystrophy. N Engl J Med 318:1363–1368

    Article  PubMed  CAS  Google Scholar 

  • Hoffman EP, Kunkel LM. (1989) Dystrophin abnormalities in Duchenne/Becker muscular dystrophy. Neuron 2:1019–1029

    Article  PubMed  CAS  Google Scholar 

  • Ibrahimov-Beskrovnaya O, Ervasti JM, Leveille CJ, Slaughter CA, Sernett SW, Campbell KP (1992) Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrix. Nature 355:696–702

    Article  Google Scholar 

  • Ionasescu V, Zellweger H (1974) Duchenne muscular dystrophy in young girls. Acta Neurol Scand 50:619–630

    Article  PubMed  CAS  Google Scholar 

  • Jackson CE, Strehler DA (1968) Limb-girdle muscular dystrophy: clinical manifestations and detection of preclinical disease. Pediatrics 41:495–502

    PubMed  CAS  Google Scholar 

  • Jamil AA, Singh B, Al-sowailem AM, Al-Deeb S, Shahwan S, Omar FZ (1992) Schwartz-Jampel syndrome: a rare disorder studied in two Saudi families. Ann Saudi Med 12:595 [Abstract]

    Google Scholar 

  • Jeanpierre M, Carrie A, Piccolo F, Leturcq F, Azibi K, De Toma C, Beldjord C, Merlini L, Voit T, Romero N, Sunada Y, Tome FMS, Fardeau M, Campbell KP, Kaplan J-C (1996) From adhalinopathies to alpha-sarcoglycanopathies: an overview. Neuromuscul Disord 6:463–465

    Article  PubMed  CAS  Google Scholar 

  • Kefi M, Amouri R, Driss A, Ben Hamida C, Ben Hamida M, Kunkel LM, Hentati F (2003) Phenotype and sarcolgycan expression in Tunisian LGMD 2C patients sharing the same del521-T mutation. Neurmuscul Disord 13:779–878

    Article  CAS  Google Scholar 

  • Khadilkar SV, Benny R (2008) Muscle disease in India. ACNR 8:13–14

    Google Scholar 

  • Khurana TS, Watkins SC, Chafey P, Chelley J, Tome FM, Fardeau M, Kaplan JC, Kunkel LM (1991) Immunolocalisation and developmental expression of dystrophin-related protein in skeletal muscle. Neuromuscul Disord 1:185–194

    Article  PubMed  CAS  Google Scholar 

  • Laporte J, Hu LJ, Kretz C, Mandel JL, Kioschis P, Coy JF, Klauck SM, Dahl N (1996) Agene mutated in x-linked myotubular myopathy defines a new putative tyrotine phosphatase family conserved in yeast. Nat Genet 13:175–182

    Article  PubMed  CAS  Google Scholar 

  • Leyten QH, Babreel FJM, Reneir WO, Ter-Laak HJ, Sengers RC, Mullaart RA (1989) Congenital muscular dystrophy. J Pediatr 115:214–221

    Article  PubMed  CAS  Google Scholar 

  • Lim LE, Duclos F, Broux O, Bourg N, Sunada Y (1995) Beta-sarcoglycan: characterization and role in limb-girdle muscular dystrophy linked to 4q12. Nat Genet 11:257–265

    Article  PubMed  CAS  Google Scholar 

  • Longman C, Brockington M, Torelli S, Jimenez-Mallebrea C, Kennedy C, Khalil N, Feng L, Saran RK, Voit T, Merlini L et al (2003) Mutations in the human LARGE gene cause MDC1D, a novel form of congenital muscular dystrophy with severe mental retardation and abnormal glycosylation of alpha-dystroglycan. Hum Mol Genet 12:2853–2861

    Article  PubMed  CAS  Google Scholar 

  • Lui J, Aoki M, Illa I, Wu C, Fardeau M, Angelini C, Serrano C, Urtizberea JA, Hentati F, Hamida MB et al (1998) Dysferlin, a novel skeletal muscle gene, is mutated in Miyoshi myopathy and limb girdle muscular dystrophy. Nat Genet 20:31–36

    Article  CAS  Google Scholar 

  • MacMichael HA (1967) A history of the Arabs in the Sudan, 1st edn. Frank Cass, London, pp 324–329

    Google Scholar 

  • Mahjneh I, Vannelli G, Bushby K, Marcone GP (1992) A large imbred Palestinian family with two forms of muscular dystrophy. Neuromuscul Disord 2:277–283

    Article  PubMed  CAS  Google Scholar 

  • Massa V, Fernandez-Vizarra E, Al Shahwan S, Bakhsh E, Goffrini P, Ferrero I, Mereghetti P, D’Adamo P, Gasparini P, Zeviani M (2008) Severe infantile encephalomyopathy caused by a mutation in COX6B1, a nucleus-encoded subunit of cytochrome c oxidase. Am J Hum Genet 82:1281–1289

    Article  PubMed  CAS  Google Scholar 

  • Matsumura K, Campbell KP (1993) Deficiency of dystrophin-associated proteins. A common mechanism leading to muscle cell necrosis in severe childhood muscular dystrophies. Neuromuscul Disord 3:109–118

    Article  PubMed  CAS  Google Scholar 

  • Matsumura K, Tome FMS, Collin H, Azibi K, Chaouch M, Kaplan J-C, Fardeau M, Campbell KP (1992) Deficiency of the 50k dystrophin-associated glycol-protein in severe childhood autosomal recessive muscular dystrophy. Nature 359:320–322

    Article  PubMed  CAS  Google Scholar 

  • McKusick VA (1994) Mendelian inheritance in man: a catalog of human genes and genetic disorders, 11th edn. Johns Hopkins University Press, Baltimore

    Google Scholar 

  • Menon K, Rao TV, Bhat BA, El Amin EO (2002) X-linked myotubular myopathy with probable germline mosaicism. Clin Neuropathol 21:265–268

    PubMed  CAS  Google Scholar 

  • Michele DE, Barresi R, Kanagawa M, Saito F, Cohn RD, Satz JZ, Dollar J, Nishino I, Kelly RI, Somer H et al (2002) Post-translational disruption of dystroglycan-ligand interactions in congenital muscular dystrophies. Nature 418:417–422

    Article  PubMed  CAS  Google Scholar 

  • Miyoshi K, Kawai H, Iwasa M, Kusaka K, Nistrino H (1986) Autosomal recessive distal muscular dystrophy as a new type of progressive muscular dystrophy. Seventeen cases in eight families including an autopsied case. Brain 109:31–54

    Article  PubMed  Google Scholar 

  • Mohamed MA (1956) Northern Sudan: population and tribes (in Arabic). Writing, Translation and Publication Committee, Cairo, pp 143–153

    Google Scholar 

  • Morgan-Hughes JA (1992) Mitochondrial diseases. In: Mastaglia FL, LordWalton of Detchant (eds) Skeletal muscle pathology. Churchill Livingstone, London, pp 367–424

    Google Scholar 

  • Muntoni F, Voit T (2004) The congenital muscular dystrophies in 2004: a century of exciting progress. Neuromuscul Disord 14:635–645

    Article  PubMed  Google Scholar 

  • Nicole S, Ben Hamida C, Baghton P, Bakouni S, Belal S, Romero N, Viljoen D, Ponsot G, Sammoud A, Weissenbach J et al (1995) Localization of the Schwartz-Jampel syndrome (SLS) locus to chromosome 1p34-p36.1 by homozygosity mapping. Hum Mol Genet 4:1633–1636

    Article  PubMed  CAS  Google Scholar 

  • Nicole S, White PS, Topaloglu H, Beigthon P, Salih M, Hentati F, Fontaine B (1999) The human CDC42 gene: genomic organization, evidence for the existence of a putative pseudogene and exclusion as a SJS1 candidate gene. Hum Genet 105:98–103

    Article  PubMed  CAS  Google Scholar 

  • Nicole S, Davoine C-S, Topaloglu H, Cattolico L, Barral D, Beighton P, Ben Hamida C, Hammouda H, Cruaud C, White PS et al (2000) Perlecan, the major proteoglycan of basement membranes, is altered in patients with Schwartz-Jampel syndrome (chondrodystrophic myotonia). Nat Genet 26:480–483

    Article  PubMed  CAS  Google Scholar 

  • Nigro V, Piluso G, Belsito A, Politano L, Puca AA, Papparella S, Rossi E, Viglietto G, Esposito MG, Abbondanza C et al (1996a) Identification of a novel sarcoglycan gene at 5q33 encoding a sarcolemmal 35 kDa glycoprotein. Hum Mol Genet 5:1179–1186

    Article  PubMed  CAS  Google Scholar 

  • Nigro V, Moreira ES, Piluso G, Vainzof M, Belsito A, Poltano L, Pucca AA, Passos-Bueno MR, Zatz M (1996b) Autosomal recessive limb-girdle muscular dystrophy, LGMD2F, is caused by a mutation in the delta-sarcoglycan gene. Nature 13:195–198

    Google Scholar 

  • Noguchi S, McNally EM, Ben Othmane K, Hagiwara Y, Mizuno Y, Yoshida M, Yamamoto H, Bönnemann CG, Gussoni E, Denton PH et al (1995) Mutations in the dystrophin-associated protein gamma-sarcoglycan in chromosome 13 muscular dystrophy. Science 270:819–822

    Article  PubMed  CAS  Google Scholar 

  • Ohlendieck K, Matsumura K, Ionasescu VV, Towbin JA, Bosch EP, Weinstein SL, Sernett SW, Campbell KP (1993) Duchenne muscular dystrophy: deficiency of dystrophin-associated proteins n the sarcolemma. Neurology 43:795–800

    Article  PubMed  CAS  Google Scholar 

  • Ozawa E, Mizuno Y, Hagiwara Y, Sasaoka T, Yoshida M (2005) Molecular and cell biology of the sarcoglycan complex. Muscle Nerve 32:563–576

    Article  PubMed  CAS  Google Scholar 

  • Passos-Bueno MR, Oliveira JR, Bakker E, Anderson RD, Marie SK, Vainzof M, Roberds S, Campbell KP, Zatz M (1993) Genetic heterogeneity for duchenne-like muscular dystrophy (DLMD) based on linkage and50 DAG analysis. Hum Mol Genet 2:1945–1947

    Article  PubMed  CAS  Google Scholar 

  • Pavone L, Mollica F, Grasso A, Cao A, Gullota F (1978) Schwartz-Jampel syndrome in two daughters of first cousins. J Neurol Neurosurg Psychiatry 41:161–169

    Article  PubMed  CAS  Google Scholar 

  • Perloff JK, Roberts WC, de Leon AC, O’Doherty D (1967) The distinctive electrocardiogram of Duchenne’s progressive muscular dystrophy. Am J Med 42:179–188

    Article  PubMed  CAS  Google Scholar 

  • Pernigo S, Fukuzawa A, Bertz M, Holt M, Reif M, Steiner RA, Gautel M (2010) Structural insight into M-band assembly and mechanics from the titin-obscurin-like-1 complex. Proc Natl Acad Sci USA 107:2908–2913

    Article  PubMed  CAS  Google Scholar 

  • Piccolo F, Roberds SL, Jeanpierre M, Leturcq F, Azibi K, Beldjord C, Carrié A, Récan D, Chaouch M, Reghis A et al (1995) Primary adhalinopathy: a common cause of autosomal recessive muscular dystrophy of variable severity. Nat Genet 10:243–245

    Article  PubMed  CAS  Google Scholar 

  • Piccolo F, Jeanpierre M, Leturcq F, Dode C, Azibi K, Toutain A, Merlini L, Jarre L, Navarro C, Krishnamoorthy R et al (1996) A founder mutation in the gamma-sarcoglycan gene of Gypsies possibly predating their migration out of India. Hum Mol Genet 5:2019–2022

    Article  PubMed  CAS  Google Scholar 

  • Poppe M, Cree L, Bourke J, Bourk J, Eagle M, Anderson LV, Burchall D (2003) The phenotype of limb-girdle muscular dystrophy type 21. Neurology 60:1230–1231

    Article  Google Scholar 

  • Radhakrishnan K, El-Mangoush MA, Se G (1987) Descriptive epidemiology of selected neuromuscular disorders in Benghazi, Libya. Acta Neurol Scand 75:95–100

    Article  PubMed  CAS  Google Scholar 

  • Rajab A, Bappol B, Al-Shaikh H, Al-Khusaibi S, Mohammaed AJ (2005) Common autosomal recessive diseases in Oman derived from a hospital-based registry. Community Genet 8:27–30

    Article  PubMed  CAS  Google Scholar 

  • Roberds SL, Anderson RD, Ibraghimov-Beskrovanya O, Campbell KP (1993a) Primary structure and muscle-specific expression of the 50-kDA dystrophin-associated glycoprotein (Adhalin). J Biol Chem 268:23739–23742

    PubMed  CAS  Google Scholar 

  • Roberds SL, Ervasti JM, Anderson RD, Ohlendieck K, Kahl SD, Zoloto D, Campbell KP (1993b) Disruption of the dystrophin-glycoprotein complex in the cardiomyopathic hamster. J Biol Chem 268:11496–11499

    PubMed  CAS  Google Scholar 

  • Roberds SL, Leturcq F, Allamand V, Piccolo F, Jean Pierre M, Anderson RD, Lim LE, Lee JC, Tome FMS, Romero NB, Fardeau M, Beckmann JS, Kaplan J-C, Campbell KP (1994) Missence mutations in the adhalin gene linked to autosomal recessive muscular dystrophy. Cell 78:625–633

    Article  PubMed  CAS  Google Scholar 

  • Romdhane NA, Ben Hamida M, Mrabet A, Larnaout A, Samoud S, Ben Hamda A, Ben Hamda M, Oueslati S (1993) Prevalence study of neurologic disorders in Kelibia (Tunisia). Neuroepidemiology 12:285–299

    Article  Google Scholar 

  • Romero NB, Tome FMS, Leturcq F, El Kerch F, Azibi K, Bachner L, Anderson RD, Roberds SL, Campbell KP, Fardeau M, Kaplan J-C (1994) Genetic heterogeneity of severe childhood autosomal recessive muscular dystrophy with adhalin (50 kDA dystrophin-associated glycoprotein) deficiency. C R Acad Sci Paris Sci vie/Life Sci 317:70–76

    CAS  Google Scholar 

  • Ryan MM, North KN (2006) Congenital myopathies. In: No Serorthy J (ed) Neurological therapeutics: principles and practice. Martin Dunitz, Rochester, NY, pp 2607–2618

    Google Scholar 

  • Salani S, Lucchiari S, Fortunato F, Crimi M, Corti S, Locatelli F, Bossolasco P, Bresolin N, Comi GP (2004) Developmental and tissue - specific regulation of a novel dysferlin isoform. Muscle Nerve 30:366–374

    Article  PubMed  CAS  Google Scholar 

  • Salih MAM (1980) Unusual muscular dystrophy in an extended Sudanese kindred. M.P.C.H. thesis, University of Khartoum

    Google Scholar 

  • Salih MAM (1982) Unusual muscular dystrophy in an extended Sudanese kindred. M.D. thesis, University of Khartoum

    Google Scholar 

  • Salih MAM (1985) Childhood muscular dystrophy: an African review. Ann Trop Paediatr 4:45–48

    Google Scholar 

  • Salih M, Urtizberea JA, Leturq F, Mukhtar M, Anderson L, Bushby K (2007) Molecular characterization and clinical update on one of the earliest described families with severe childhood autosomal recessive muscular dystrophy (SCARMD). Neuromuscl Disord 17:813 [Abstract]

    Google Scholar 

  • Salih MAM, Omer MIA, Bayoumi RA, Karrar O, Johnson M (1983) Severe autosomal recessive muscular dystrophy in an extended Sudanese kindred. Dev Med Child Neurol 25:43–52

    Article  PubMed  CAS  Google Scholar 

  • Salih MAM, Ekmejian A, Omer MIA (1984) Respiratory insufficiency in a severe autosomal recessive form of muscular dystrophy. Ann Trop Paediatr 4:45–48

    PubMed  CAS  Google Scholar 

  • Salih MAM, Mahdi AH, Al-Jarallah AA, Al-Jarallah AS, Al-Saadi M, Hafeez MA, Aziz SA (1992) Childhood neuromuscular disorders in Saudi Arabia: a decade’s experience in a tertiary hospital. In: Proceedings of the First Congress of the Saudi Benevolent Association for Disabled Children, Riyadh [Abstract]

    Google Scholar 

  • Salih MAM, Ruitenbeek W, Dincsoy MY, van Oost BA, Abo-Hassan H, Ozo C, Al-Rikabi AC (1994b) Familial childhood mitochondrial disease in Saudi Arabia: defective energy metabolism presenting as an emergency. In: Proceedings of the 7th Paediatric Symposium, Riyadh, Saudi Arabia [Abstract]

    Google Scholar 

  • Salih MAM, Mahdi AH, Al-Jarallah AA, Al-Jarallah AS, Al-Saadi M, Hafeez MA, Aziz SA (1996a) Childhood neuromuscular disorders in Saudi Arabia: a decade’s experience in a tertiary hospital. Ann Trop Paediatr 16:271–280

    PubMed  CAS  Google Scholar 

  • Salih MAM, Mahdi A, Al-Rikabi AC, Al-Bunyan M, Roberds SL, Anderson RD, Campbell KP (1996b) Clinical and molecular pathological features of childhood autosomal recessive muscular dystrophy in Saudi Arabia. Dev Med Child Neurol 38(3):262–270

    Article  PubMed  CAS  Google Scholar 

  • Salih MA, Sunada Y, Al-Nasser M, Ozo CO, Al-Turaiki MH, Akbar M, Campbell KP (1996c) Muscular dystrophy associated with beta-dystroglycan deficiency. Ann Neurol 40:925–928

    Article  PubMed  CAS  Google Scholar 

  • Salih MA, Al Rayesi M, Cutshall S, Urtizberca JA, Al-Turaiki MH, CO OZO, Straub V, Akbar M, Abid M, Andeejani A et al (1998) A novel form of familial congenital muscular dystrophy in two adolescents. Neuropediatrics 29:289–293

    Article  PubMed  CAS  Google Scholar 

  • Salih MA, Abdel-Gader AG, Zahraa JN, Al-Rayess MM, Alorainy IA, Hassan HH, Ruitenbeek W, Zeviani M (2006) Stroke due to mitochondrial disorders in Saudi children. Saudi Med J 27(Suppl 1):S81–S90

    PubMed  Google Scholar 

  • Santavouri P, Leisto J, Kruus S (1977) Muscle, eye and brain disease: a new syndrome. Neuropadiatrie 8(Suppl):553–558

    Google Scholar 

  • Sawardekar KP (2005) Profile of major congenital malfomartions at Nizwa Hospital, Oman: 10 year review. J Pediatr Child Health 41:323–330

    Article  Google Scholar 

  • Scaglia F, Towbin JA, Craigen WJ, Belmont JW, Smith EO, Neish SR, Ware SM, Hunter JV, Fernbach SD, Vladutin GD et al (2004) Clinical spectrum, morbidity, mortality in 113 pediatric patients with mitochondrial disease. Pediatrics 114:925–931

    Article  PubMed  Google Scholar 

  • Schwartz O, Jampel RS (1962) Congenital blepharophimosis associated with a unique generalized myopathy. Arch Opthlamol 68:82–87

    Google Scholar 

  • Seidahmed MZ, Sunada Y, Ozo CO, Hamid F, Campbell KP, Salih MAM (1996) Lethal congenital muscular dystrophy in two sibs with orthrogryposis multiplex: new entity or variant of cobblestone lissencephaly syndrome? Neuropediatrics 27:305–310

    Article  PubMed  CAS  Google Scholar 

  • Sewry CA, Sansome A, Matsumura K, Campbell KP, Dubowitz V (1994) Deficiency of the 50 kDA dystrophin-associated glycoprotein and abnormal expression of utrophin in two South Asian cousins with variable expression of severe childhood autosomal recessive muscular dystrophy. Neuromuscul Disord 4:121–129

    Article  PubMed  CAS  Google Scholar 

  • Sewry CA, Jimenez-Mallebrea C, Muntoni F (2008) Congenital myopathies. Curr Opin Neurol 21:569–575

    Article  PubMed  Google Scholar 

  • Shokeir MH, Kobrinsky NL (1976) Autosomal recessive muscular dystrophy in Manitoba Hutterites. Clin Genet 9:197–202

    Article  PubMed  CAS  Google Scholar 

  • Soussi-Yanicostas N, Ben Hamida C, Butler-Browne GS, Hentati F, Bejaoui K, Ben Hamida M (1991) Modification in the expression and localization of contractile and cytoskeletal proteins in Schwartz-Jampel syndrome. J Neurol Sci 104:64–73

    Article  PubMed  CAS  Google Scholar 

  • Specht LA, Kunkel LM (1993) Duchenne and Becker muscular dystrophies. In: Rosenberg RN, Prusiner SB, DiMauro S, Barchi RL, Kunkel LM (eds) The molecular and genetic basis of neurological disease. Butterworth-Heinemann, Boston, pp 613–631

    Google Scholar 

  • Stern LM (1972) Four cases of Duchenne-type muscular dystrophy in girls. Med J Aust 2:1066–1069

    PubMed  CAS  Google Scholar 

  • Stum M, Davone CS, Vicart S, Guillot-Noel, Topaloglu H, Carod-Artal FJ, Kayserili H, Hentati F, Merlini L, Urtizberea JA, et al (2006) Spectrum of HSPG2 (Perlecan) mutations in patients with Schwartz – Jampel syndrome. Hum Mutat 27:1082–1091

    Article  PubMed  CAS  Google Scholar 

  • Sztriha L, Al-Gazali LI, Varady E, Goebel HH, Nork M (1999) Autosomal recessive micrencephaly with simplified gyral pattern, abnormal myelination and arthrogryposis. Neuropediatrics 30:141–145

    Article  PubMed  CAS  Google Scholar 

  • Tanner SM, Orstavik KH, Kristiansen M, Lev D, Lerman-Sagie T, Sadeh M, Liechti-Gallati S (1999) Skewed X-inactivation in a manifesting carrier of X-linked myotubular myopathy and in her non-manifesting camir mother. Hum Genet 104:249–253

    Article  PubMed  CAS  Google Scholar 

  • Taylor R, Turnbull D (2005) Mitochondrial DNA mutation in human disease. Nat Rev Genet 6:389–402

    Article  PubMed  CAS  Google Scholar 

  • Topaloğlu H, Yalaz K, Renda Y, Cağlar M, Göğüs S, Kale G, Gücüyener K, Nurlu G (1991) Occidental type cerebromuscular dystrophy: a report of eleven cases. J Neurol Neurosurg Psychiatry 54:226–229

    Article  PubMed  Google Scholar 

  • Tulinius MJ, Holme E, Kristianssonn B, Larsson NG, Oldfors A (1991) Mitochondrial encephalopathies in childhood. II. Clinical manifestation and syndromes. J Pediatr 119:242–250

    Article  PubMed  CAS  Google Scholar 

  • Urtizberea Ja, Bassez G, Letureq F, Nguyen K, Kraln M, Levy N (2008) Dysferlinopathies. Neurol India 56:289–297

    Article  PubMed  Google Scholar 

  • Van Essen AJ, Busch HF, te Meerman GJ, ten Kate LP (1992) Birth and population prevalence of Duchenne muscular dystrophies in the Netherlands. Hum Genet 88:258–266

    Google Scholar 

  • Van Reeuwijk J, Gerwald PK, Salih MAM, Daniel Beltran-Valero de Bernabe, McLaughlan JM, Michielse CB, Herrman R, Hewitt JE, Steinbrecher A, Seidahmed MZ, et al (2007) Intragenic deletion in the LARGE gene causes Walker-Warburg syndrome. Hum Genet 121:685–690

    Article  PubMed  Google Scholar 

  • Vermeer S, Verrips A, Willemsen MA, ter Laak HJ, Ginjaar IB, Hamel BC (2004) Novel mutations in three patients with LGMD2C with phenotypic differences. Pediatr Neurol 30:291–294

    Article  PubMed  Google Scholar 

  • Wong L-J C, Boles RG (2005) Mitochondrial DNA analysis in clinical laboratory diagnostics. Clin Chem Acta 354:1–20

    Article  CAS  Google Scholar 

  • Yakota T, Lu Q, Partridge, Kobayashi M, Nakamura A, Takeda S, Hoffman E (2009) Effficiency of systemic mrpholine exon-shipping in Duchenne dystrophy dogs. Ann Neurol 65:667–676

    Article  Google Scholar 

  • Zatz M, Passos-Bueno MR, Rapaport D (1989) Estimate of the proportion of Duchenne muscular dystrophy with autosomal recessive inheritance. Am J Med Genet 32:407–410

    Article  PubMed  CAS  Google Scholar 

  • Zeviani M, Di Donato S (2004) Mitochondrial disorders. Brain 127:2153–2172

    Article  PubMed  Google Scholar 

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Acknowledgments

I express my appreciation for the members of the Department of Pathology, College of Medicine, King Saud University, for the help they offered throughout the various stages of this study. Thanks are due to Vir Salvador and Babiker Faragab for medical illustration and for Rowena Fajardo and Loida M. Sese for typing the manuscript.

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  1. Division of Pediatric Neurology, Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia

    Mustafa A. M. Salih

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  1. Qatar Foundation, Weill Cornell Medical College in Qatar, Doha, Qatar

    Ahmad S. Teebi

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Salih, M.A.M. (2010). Muscular Dystrophies and Myopathies in Arab Populations. In: Teebi, A. (eds) Genetic Disorders Among Arab Populations. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-05080-0_6

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