Abstract
The segregation and differentiation of the germ and somatic cell lines in animal embryos represent one of the basic events in cell and developmental biology and has attracted classical and contemporary researchers alike. The process of germ line-soma segregation singles out cells which have to maintain the genealogy and those which build up the individual organism. This event often constitutes the first sign of differentiation in early cleavage stages of a developing embryo. Understanding, in molecular-genetic terms, such a basic developmental process might give us some clues to solve the most important problem in developmental biology, i.e., how cells become different during development. Although this review will focus on a discussion of germ line versus soma differentiation, it should be emphasized that the underlying mechanism(s) involved in the differentiation of the divergent somatic cell lines may in principle be similar.
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References
Aeby P (1979) Determination du nombre de gènes codant pour l’ARN de transfert dans les lignées germinale et somatique de l’Ascaris lumbricoides (var. suum). Dipl thesis, Univ Freiburg, Switzerland
Akifjew AP (1974) Silent DNA and its role in evolution (Russ.) Priroda 9: 49–54
Albertson DG, Nwaorgu OC, Sulston JE (1979) Chromatin diminution and a chromosomal mechanism of sexual differentiation in Strongyloides papillosus. Chromosoma 75: 75–87
Ammermann D (1965) Cytologische und genetische Untersuchungen an dem Ciliaten Stylonychia mytilus Ehrenberg. Arch Protistenkd 108: 109–152
Ammermann D (1967) Die Cytologie der Parthenogenese bei dem Tardigraden Hypsibius dujardini. Chromosoma 23: 203–213
Ammermann D (1971) Morphology and development of the macronuclei of the ciliates Stylonychia mytilus and Euplotes aediculatus. Chromosoma 33: 209–238
Ammermann D (1986) Chromatin diminution and chromosome elimination: Mechanisms and adaptive significance. In: Cavalier-Smith T (ed) DNA and evolution: Natural selection and genome size. Wiley, New York, in press
Ammermann D, Steinbrück G (1981) Methylated bases in the DNA of the ciliate Stylonychia mytilus. Eur J Cell Biol 24: 154–156
Andersen HA (1972) Induced elimination of DNA from macronucleus of Tetrahymena pyriformis. Exp Cell Res 74: 610–613
Anya AO (1976) Physiological aspects of reproduction in nematodes. In: Dawes B (ed) Advances in parasitology, vol 14. Academic Press, London New York, pp 267–351
Back E, Müller F, Tobler H (1984a) Structural organization of the two main rDNA size classes of Ascaris lumbricoides. Nucleic Acids Res 12: 1313–1332
Back E, Felder H, Müller F, Tobler H (1984b) Chromosomal arrangement of the two main rDNA size classes of Ascaris lumbricoides. Nucleic Acids Res 12: 1333–1347
Back E, Van Meir E, Müller F, Schaller D, Neuhaus H, Aeby P, Tobler H (1984c) Intervening sequences in the ribosomal RNA genes of Ascaris lumbricoides: DNA sequences at junctions and genomic organization. EMBO J 3: 2523–2529
Baltzer F (1962) Theodor Boveri. Wiss Verlagsges MBH, Stuttgart, pp 1–194
Banerjee MR (1959) Chromosome elimination during meiosis in the males of Macroceroea (Lohita) grandis (Gray) (Pyrrhocoridae, Heteroptera). Proc Zool Soc (Calcutta) 12: 1–8
Bantock CR (1961) Chromosome elimination in cecidomyidae. Nature (London) 190: 466–467
Bantock CR (1970) Experiments on chromosome elimination in the gall midge, Mayetiola destructor. J Embryol Exp Morphol 24: 257–286
Basile R (1966) Estudo da espermatogênese e da ovogênes em Rhynchosciara angelae e da sintese de âcidos nucléicos e de proteinas no ovârio. PhD thesis, Univ Sao Paulo, Sao Paulo
Bauer H (1932) Die Feulgensche Nuklealfärbung in ihrer Anwendung auf cytologische Untersuchungen. Z Zellforsch 15: 225–247
Bauer H (1933) Die wachsenden Oocytenkerne einiger Insekten in ihrem Verhalten zur Nuklealfärbung. Z Zellforsch 18: 254–298
Bauer H, Beermann W (1952a) Chromosomale Soma-Keimbahn-Differenzierung bei Chironomiden. Naturwissenschaften 39: 22–23
Bauer H, Beermann W (1952b) Der Chromosomencyclus der Orthocladiinen ( Nematocerca, Diptera). Z Naturforsch 7b: 557–563
Beams HW, Kessel RG (1974) The problem of germ cell determinants. In: Boume GH, Danielli JF, Jeon KW (eds) Int Rev Cytol Academic Press, London New York, pp 418–479
Beauchamp RS, Pasternak J, Straus NA (1979) Characterization of the genome of the free-living nematode Panagrellus silusiae: Absence of short period interspersion. Biochemistry 18: 245–251
Beermann S (1959) Chromatin-Diminution bei Copepoden. Chromosoma 10: 504–514
Beermann S (1977) The diminution of heterochromatic chromosomal segments in Cyclops (Crustacea, Copepoda). Chromosoma 60: 297–344
Beermann S (1984) Circular and linear structures in chromatin diminution of Cyclops. Chromo-soma 89: 321–328
Beermann S, Meyer GF (1980) Chromatin rings as products of chromatin diminution in Cyclops. Chromosoma 77: 277–283
Beermann W (1952) Chromomerenkonstanz und spezifische Modifikationen der Chromosomenstruktur in der Entwicklung und Organdifferenzierung von Chironomus tentans. Chromosoma 5: 139–198
Beermann W (1972) Chromomeres and genes. In: Beermann W (ed) Developmental studies on giant chromosomes. Results and problems in cell differentiation, vol IV. Springer, Berlin Heidelberg New York, pp 1–33
Beneden E (1983) Recherches sur la maturation de l’oeuf et la fécondation. Arch Biol 4: 265–641
Bennett FD, Brown SW (1958) Life history and sex determination in the diaspine scale, Pseudaulacaspis pentagona (Targ.) ( Coccoidea ). Can Entomol 90: 317–324
Bielka H, Schultz I, Böttger M (1968) Isolation and properties of DNA from eggs and gastrulae of Ascaris lumbricoides. Biochim Biophys Acta 157: 209–212
Biocca E, Nascetti G, lori A, Costantini R, Bullini L (1978) Descrizione di Parascaris univalens, parassita degli equini, e suo differenziamento da Parascaris equorum. Atti Accad Naz Lincei Cl Sci Fis Mat Nat Rend 65: 133–141
Blackler AW (1958) Contribution to the study of germ-cells in the anura. J Embryol Exp Morphol 6: 491–503
Bonnevie K (1902) Über Chromatindiminution bei Nematoden. Jena Z Naturwiss 36: 275–288
Bostock C (1980) A function for satellie DNA? TIBS 5: 117–119
Bounoure L (1939) L’origine des cellules reproductrices et le problème de la lignée germinale. Gauthier-Villars, Paris
Boveri T (1887) Über Differenzierung der Zellkerne während der Furchung des Eies von Ascaris megalocephala. Anat Anz 2: 688–693
Boveri T (1888) Zellenstudien II. Die Befruchtung und Teilung des Eies von Ascaris megalocephala. Jena Z Naturwiss 22: 685–882
Boveri T (1892) Über die Entstehung des Gegensatzes zwischen den Geschlechtszellen und den somatischen Zellen bei Ascaris megalocephala, nebst Bemerkungen zur Entwicklungsgeschichte der Nematoden. Sitzungsber Ges Morphol Physiol München 8: 114–125
Boveri T (1899) Die Entwicklung von Ascaris megalocephala mit besonderer Rücksicht auf die Kernverhältnisse. In: Festschrift für C von Kupffer. Fischer, Jena, pp 383–430
Boveri T (1904) Ergebnisse über die Konstitution der chromatischen Substanz des Zellkerns. Jena, Fischer, pp 1–130
Boveri T (1910a) Über die Teilung centrifugierter Eier von Ascaris megalocephala. Arch Entwicklungsmech Org 30: 101–125
Boveri T (1910b) Die Potenzen der Ascaris-Blastomeren bei abgeänderter Furchung. Zugleich ein Beitrag zur Frage qualitativ-ungleicher Chromosomen-Teilung. Festschr für R. Hertwig, vol III. Fischer, Jena, pp 131–214
Britten RJ, Kohne DE (1966) Nucleotide sequence repetition in DNA. Carnegie Inst Washington Yearb 65: 78–106
Britten RJ, Kohne DE (1968) Repeated sequences in DNA. Science 161: 529–540
Brown DD (1984) The role of stable complexes that repress and activate cucaryotic genes. Cell 37: 359–365
Brown DD, Dawid IB (1968) Specific gene amplification in oocytes. Science 160: 272–280
Brown SW, Bennett FD (1957) On sex determination in the diaspine scale Pseudaulacaspis pentagona (Targ.) ( Coccoidea ). Genetics 42: 510–523
Brown SW, Chandra HS (1977) Chromosome imprinting and the differential regulation of homologous chromosomes. In: Goldstein L, Prescott DM (eds) Cell biology: A comprehensive treatise, vol I. Genetic mechanisms of cells. Academic Press, London New York, pp 109–189
Bueding E, Orrell SA (1964) A mild procedure for the isolation of polydisperse glycogen from animal tissues. J Biol Chem 239: 4018–4020
Bullini L, Nascetti G, Ciafrè S, Rumore F, Biocca E (1978) Ricerche cariologiche ed elettroforetiche su Parascaris univalens e Parascaris equorum. Atti Accad Naz Lincei Cl Sci Fis Mat Nat Rend 65: 151–159
Camenzind R (1971) The cytology of paedogenesis in the gall midge Mycophila speyeri. Chromosoma 35: 393–402
Cameron JR, Loh EY, Davis RW (1979) Evidence for transposition of dispersed repetitive DNA families in yeast. Cell 16: 739–751
Carter CE, Wells JR, Maclnnis AJ (1972) DNA from anaerobic adult Ascaris lumbricoides and Hymenolepis diminuta mitochondria isolated by zonal centrifugation. Biochim Biophys Acta 262: 135–144
Chitwood BG, Chitwood MB (1950) An introduction to nematology. Baltimore Monumental Printing, Baltimore, pp 1–213
Close RL (1984) Rates of sex chromosome loss during development in different tissues of the bandicoots Perameles nasuta and Isoodon macrourus (Marsupialia: Peramelidae). Aust J Biol Sci 37: 53–61
Cooper DN (1983) Eukaryotic DNA methylation. Hum Genet 64: 315–333
Cooper KW (1939) The nuclear cytology of the grass mite, Pediculopsis graminum (Reut.), with special reference to karyomerokinesis. Chromosoma 1: 51–103
Croce CM, Kieba I, Koprowski H (1973) Unidirectional loss of human chromosomes in rat-human hybrids. Exp Cell Res 79: 461–463
Crouse HV, Brown A, Mumford BC (1971) L-chromosome inheritance and the problem of chromosome “imprinting” in Sciara ( Sciaridae, Diptera). Chromosoma 34: 324–339
Dale PJ (1983) Protoplast culture and plant regeneration of cereals and other recalcitrant crops. Experientia Suppl 46: 31–41
Darlington CD (1956) Chromosome Botany. Allen and Unwin, London, pp 1–186
Davey MR (1983) Recent developments in the culture and regeneration of plant protoplasts. Experientia Suppl 46: 19–29
Davidson EH (1976) Gene activity in early development, 2nd edn. Academic Press, London New York, pp 1–452
Davidson EH, Hough BR, Amenson CS, Britten RJ (1973) General interspersion of repetitive with non-repetitive sequence elements in the DNA of Xenopus. J Mol Biol 77: 1–23
Davis AH, Kidd GH, Carter CE (1979) Chromosome diminution in Ascaris suum. Two-fold increase of nucleosomal histone to DNA ratios during development. Biochim Biophys Acta 565: 315–325
Dawson D, Buckley B, Cartinhour S, Myers R, Herrick G (1984) Elimination of germ-line tandemly repeated sequences from the somatic genome of the ciliate Oxytricha fallax. Chromo-soma 90: 289–294
DiBerardino MA, Hoffner YN, Etkin LD (1984) Activation of dormant genes in specialized cells. Science 224: 946–952
Dixon KE (1981) The origin of the primordial germ cells in the amphibia. Neth J Zool 31: 5–37
Doerfler W (1983) DNA methylation and gene activity. Annu Rev Biochem 52: 93–124
DuBois AM (1932) Elimination of chromosomes during cleavage in the eggs of Sciara (Diptera). Proc Natl Acad Sci USA 18: 352–356
DuBois AM (1933) Chromosome behavior during cleavage in the eggs of Sciara coprophila (Diptera) in the relation to the problem of sex determination. Z Zellforsch 19: 595–614
Eddy EM (1975) Germ plasm and the differentiation of the germ cell line. In: Boume GH, Danielli JF, Jeon KW (eds) International review of cytology. Academic Press, London New York, pp 229–280
Eddy EM, Clark JM, Gong D, Fenderson BA (1981) Review article: Origin and migration of primordial germ cells in mammals. Gamete Res 4: 333–362
Edwards CL (1910a) The sex-determining chromosomes in Ascaris. Science 31: 514–515
Edwards CL (1910b) The idiochromosomes in Ascaris megalocephala and Ascaris lumbricoides. Arch Zellforsch 5: 422–429
Einsle U (1964) Die Gattung Cyclops s. str. im Bodensee. Arch Hydrobiol 60: 133–199
Emmons SW, Yesner L (1984) High-frequency excision of transposable element Tel in the nematode Caenorhabditis elegans is limited to somatic cells. Cell 36: 599–605
Emmons SW, Klass MR, Hirsh D (1979) Analysis of the constancy of DNA sequences during development and evolution of the nematode Caenorhabditis elegans. Proc Natl Acad Sci USA 76: 1333–1337
Emmons SW, Rosenzweig B, Hirsh D (1980) Arrangement of repeated sequences in the DNA of the nematode Caenorhabditis elegans. J Mol Biol 144: 481–500
Emmons SW, Yesner L, Ruan K, Katzenberg D (1983) Evidence for a transposon in Caenorhabditis elegans. Cell 32: 55–65
Endow SA, Gall JG (1975) Differential replication of satellite DNA in polyploid tissues of Drosophila virilis. Chromosoma 50: 175–192
Evans D, Birnstiel ML (1968) Localization of amplified ribosomal DNA in the oocyte of Xenopus laevis. Biochim Biophys Acta 166: 274–276
Fedoroff NV (1984) Transposable genetic elements in maize. Sci Am 250, 6: 64–74
Felder H (1983) Lokalisierung von hochrepetitiven DNA-Sequenzen und ribosomalen Genen auf Chromosomen von Ascaris lumbricoides var. suum mittels in situ-Hybridisierungsexperimenten. Dipl thesis, Univ Freiburg, Switzerland, pp 1–54
Finch RA (1983) Tissue-specific elimination of alternative whole parental genomes in one barley hybrid. Chromosoma 88: 386–393
Finnegan DJ, Rubin GM, Young MW, Hogness DS (1978) Repeated gene families in Drosophila melanogaster. Cold Spring Harbor Symp Quant Biol 42: 1053–1063
Fogg LC (1930) A study of chromatin diminution in Ascaris and Ephestia. J Morphol 50: 413
Fux T (1974) Chromosome elimination in Heteropeza pygmaea. II. Ultrastructure of the spindle apparatus. Chromosoma 49: 99–112
Gall JG (1968) Differential synthesis of the genes for ribosomal RNA during amphibian oögenesis. Proc Natl Acad Sci USA 60: 553–560
Gall JG (1981) Chromosome structure and the C-value paradox. J Cell Biol 91: 3s-14s
Gartler SM, Riggs AD (1983) Mammalian X-chromosome inactivation. Annu Rev Genet 17: 155–190
Geigy R (1931) Action de l’ultra-violet sur le pôle germinal dans l’oeuf de Drosophila melanogaster (Castration et mutabilité). Rev Suisse Zool 38: 187–288
Gerbi S (1986) Chromosome mechanics in Sciarids (this Vol)
Gerhart JC (1980) Mechanisms regulating pattern formation in the amphibian egg and early embryo. In: Goldberger RF (ed) Biological regulation and development, vol II. Plenum Press, New York, pp 133–316
Geyer-Duszynska I (1959) Experimental research on chromosome elimination in Cecidomyidae (Diptera). J Exp Zool 141: 391–447
Geyer-Duszynska I (1966) Genetic factors in oögenesis and spermatogenesis in Cecidomyiidae. In: Darlington CD, Lewis KR (eds) Chromosomes today, vol I. Oliver and Boyd, Edinburgh, pp 174–178
Goday C, Pimpinelli S (1984) Chromosome organization and heterochromatin elimination in Parascaris. Science 224: 411–413
Goday C, Ciofi-Luzzatto A, Pimpinelli S (1985) Centromere ultrastructure in germ-line chromosomes of Parascaris. Chromosoma 91: 121–125
Goldschmidt RB, Lin TP (1947) Chromatin diminution in Ascaris. Science 105: 619
Goldstein P (1977) Chromatin diminution in early embryogenesis of Ascaris lumbricoides L. var. suum. J Morphol 152: 141–151
Goldstein P (1978) Ultrastructural analysis of sex determination in Ascaris lumbricoides var. suum. Chromosoma 66: 59–69
Goldstein P, Moens PB (1976) Karyotype analysis of Ascaris lumbricoides var. suum. Male and female pachytene nuclei by 3-D reconstruction from electron microscopy of serial sections. Chromosoma 58: 101–111
Goldstein P, Straus NA (1978) Molecular characterization of Ascaris suum DNA and of chromatin diminution. Exp Cell Res 116: 462–466
Goodrich HB (1916) The germ cells in Ascaris incurva. J Exp Zool 21: 61–99
Goswami U (1973) Chromatin elimination in a rare species of nematode Physaloptera indiana. Curr Sci 42: 576–577
Grimm C, Kunz W (1980) Disproportionate rDNA replication does occur in diploid tissue in Drosophila hydei. Mol Gen Genet 180: 23–26
Grimm C, Kunz W, Franz G (1984) The organ-specific rRNA gene number in Drosophila hydei is controlled by sex heterochromatin. Chromosoma 89: 48–54
Gurdon JB (1974) The control of gene expression in animal development. Clarendon Press, Oxford, pp 1–160
Gurdon JB, Uehlinger V (1966) “Fertile” intestine nuclei. Nature (London) 210:1240–1241
Gurdon JB, Laskey RA, Reeves OR (1975) The developmental capacity of nuclei transplanted from keratinized skin cells of adult frogs. J Embryol Exp Morphol 34: 93–112
Hadorn E (1965) Problems of determination and transdetermination. In: Genetic control of differentiation. Brookhaven Natl Lab New York 18: 148–159
Hadorn E (1978) Transdetermination. In: Ashburner M, Wright TRF (eds) The genetics and biology of Drosophila, vol II c. Academic Press, London New York, pp 555–617
Hatt P (1931) La fusion expérimentale d’oeufs de „Sabellaria alveolata L.“ et leur développement. Arch Biol 42: 303–323
Hayman DL, Martin PG (1965) Sex chromosome mosaicism in the marsupial genera Isoodon and Perameles. Genetics 52: 1201–1206
Hayman DL, Martin PG (1969) Cytogenetics of marsupials. In: Benirschke K (ed) Comparative mammalian cytogenetics. Springer, Berlin Heidelberg New York, pp 191–217
Hegner RW (1911) Germ-cell determinants and their significance. Am Nat 45: 385–397
Hegner RW (1914) Studies on germ cells. J Morpho! 25: 375–509
Hennig W (1986) Heterochromatin and germ line limited DNA (this Vol)
Hennig W, Meer B (1971) Reduced polyteny of ribosomal RNA cistrons in giant chromosomes of Drosophila hydei. Nature (London) New Biol 233: 70–72
Herla V (1893) Etude des variations de la mitose chez l’Ascaride mégalocéphale. Arch Biol 13: 423–520
Hertwig R (1903) Über Korrelation von Zell-und Kerngröße und ihre Bedeutung für die geschlechtliche Differenzierung und die Teilung der Zelle. Biol Centralbl 23: 49–62.
Hillman N, Sherman MI, Graham C (1972) The effect of spatial arrangement on cell determination during mouse development. J Embryol Exp Morphol 28: 263–278
Hilscher W (1983) Problems of the Keimbahn. In: Hilscher W (ed) Problems of the Keimbahn, new work on mammalian germ cell lineage. Karger, Basel, pp 1–21
Hogue MJ (1910) Über die Wirkung der Centrifugalkraft auf die Eier von Ascaris megalocephala. Arch Entwicklungsmech Org 29: 109–145
Huettner AF (1934) Octoploidy and diploidy in Miastor americana. Anat Rec 60 (Suppl): 80
Illmensee K, Mahowald AP (1974) Transplantation of posterior polar plasm in Drosophila. Induction of germ cells at the anterior pole of the egg. Proc Natl Acad Sci USA 71: 1016–1020
Illmensee K, Mahowald AP (1976) The autonomous function of germ plasm in a somatic region of the Drosophila egg. Exp Cell Res 97: 127–140
Jaenisch R, Jähner D (1984) Methylation, expression and chromosomal position of genes in mammals. Biochim Biophys Acta 782: 1–9
Jelinek WR, Schmid CW (1982) Repetitive sequences in eukaryotic DNA and their expression. Annu Rev Biochem 51: 813–844
Ju-Chi-Li (1937) A six-chromosome Ascaris in Chinese horses. Science 86: 101–102
Judd BH, Shen MW, Kaufman TC (1972) The anatomy and function of a segment of the X chromosome of Drosophila melanogaster. Genetics 71: 139–156
Kahle W (1908) Die Paedogenesis der Cecidomyiden. Zoologica 21: 1–80
Kaput J, Sneider TW (1979) Methylation of somatic vs germ cell DNAs analyzed by restriction endonuclease digestions. Nucleic Acids Res 7: 2303–2322
Kaulenas MS, Fairbairn D (1968) RNA metabolism of fertilized Ascaris lumbricoides eggs during uterine development. Exp Cell Res 52: 233–251
Kautzsch G (1913) Studien über Entwicklungsanomalien bei Ascaris. II. Arch Entwicklungsmech Org 35: 642–691
Kilejian A, Maclnnis AJ (1976) Density distribution of DNA from parasitic helminths with special reference to Ascaris lumbricoides. Rice Univ Stud 62: 161–174
Kimble J, Hirsh D (1979) The postembryonic cell lineages of the hermaphrodite and male gonads in Caenorhabditis elegans. Dev Biol 70: 396–417
King RL, Beams HW (1937) Effect of ultra-centrifuging on the egg of Ascaris megalocephala. Nature (London) 139: 369–370
King RL, Beams HW (1938) An experimental study of chromatin diminution in Ascaris. J Exp Zool 77: 425–443
Klingstedt H (1931) Digametie beim Weibchen der Trichoptere Limnophilus decipiens (Kol). Acta Zool Fenn 10: 1–69
Kovaleva VG, Raikov I B (1978) Diminution and re-synthesis of DNA during development and senescence of the “diploid” macronuclei of the ciliate Trachelonema sulcata ( Gymnostomata, Karyorelictida). Chromosoma 67: 177–192
Krieg C, Cole T, Deppe U, Schierenberg E, Schmitt D, Yoder B, von Ehrenstein G (1978) The cellular anatomy of embryos of the nematode Caenorhabditis elegans. Dev Biol 65: 193–215
Krüger E (1913) Fortpflanzung und Keimzellenbildung von Rhabditis aberrans, nov sp. Z Wiss Zool 105: 87–124
Kühn A (1971) Lectures on developmental physiology, 2nd edn. Springer, Berlin Heidelberg New York, pp 1–535
Kuhn O, Tobler H (1978) Quantitative analysis of RNA, glycogen and nucleotides from different developmental stages of Ascaris lumbricoides (var. suum). Biochim Biophys Acta 521: 251–266
Kunz W (1970) Genetische Aktivität der Keimbahnchromosomen während des Eiwachstums von Gallmücken (Cecidomyiidae). Verh Dtsch Zool Ges 1970: 42–46
Kunz W, Schäfer U (1976) Variations in the number of the Y chromosomal rRNA genes in Drosophila hydei. Genetics 82: 25–34
Kunz W, Trepte HH, Bier K (1970) On the function of the germ line chromosomes in the oogenesis of Wachtliella persicariae ( Cecidomyiidae ). Chromosoma 30: 180–192
Landolt P, Tobler H (1980) The somatic DNA of Ascaris lumbricoides shows short-period interspersion. Experientia 36: 750
Laskey RA, Gurdon JB (1970) Genetic content of adult somatic cells tested by nuclear transplantation from cultured cells. Nature (London) 228: 1332–1334
Laufer JS, Ehrenstein G von (1981) Nematode development after removal of egg cytoplasm: Absence of localized unbound determinants. Science 211: 402–405
Laufer JS, Bazzicalupo P, Wood WB (1980) Segregation of developmental potential in early embryos of Caenorhabditis elegans. Cell 19: 569–577
Lauth MR, Spear BB, Heumann J, Prescott DM (1976) DNA of ciliated protozoa: DNA sequence diminution during macronuclear development of Oxytricha. Cell 7: 67–74
Levine M, Garen A, Lepesant JA, Lepesant-Kejzlarova J (1981) Constancy of somatic DNA organization in developmentally regulated regions of the Drosophila genome. Proc Natl Acad Sci USA 78: 2417–2421
Lewin R (1982) Repeated DNA still in search of a function. Science 217: 621–623
Liao LW, Rosenzweig B, Hirsh D (1983) Analysis of a transposable element in Caenorhabditis elegans. Proc Natl Acad Sci USA 80: 3585–3589
Lima-de-Faria A (1975) The relation between chromomeres, replicons, operons, transcription units, genes, viruses and palindromes. Hereditas 81: 249–284
Lima-de-Faria A (1983) Molecular evolution and organization of the chromosome. Elsevier, Amsterdam, pp 1–1186
Lin TP (1954) The chromosomal cycle in Parascaris equorum (Ascaris megalocephala): Oogenesis and diminution. Chromosoma 6: 175–198
Livak KJ, Freund R, Schweber M, Wensink PC, Meselson M (1978) Sequence organization and transcription at two heat shock loci in Drosophila. Proc Natl Acad Sci USA 75: 5613–5617
Mahowald AP (1968) Polar granules of Drosophila. II. Ultrastructural changes during early embryogenesis. J Exp Zool 167: 237–262
Mahowald AP (1971a) Polar granules of Drosophila. IV. Cytochemical studies showing loss of RNA from polar granules during early stages of embryogenesis. J Exp Zool 176: 345–352
Mahowald AP (1971b) Origin and continuity of polar granules. In: Reinert J, Ursprung H (eds) Results and problems in cell differentiation, vol II. Origin and continuity of cell organelles. Springer, Berlin Heidelberg New York, pp 158–169
Mahowald AP, Allis CD, Karrer KM, Underwood EM, Waring GL (1979) Germ plasm and pole cells of Drosophila. In: Subtelny S, Konigsberg IR (eds) Determinants of spatial organization. Academic Press, London New York, pp 127–146
Mangold O (1923) Transplantationsversuche zur Frage der Spezifität and der Bildung der Keimblätter bei Triton. Arch Mikrosk Anat Entwicklungsmech 100: 198–301
Mangold O, Seidel F (1927) Homoplastische and heteroplastische Verschmelzung ganzer Triton-keime. Wilhelm Roux ’ Arch Entwicklungsmech Org 111: 593–665
Markert CL, Petters RM (1978) Manufactured hexaparental mice show that adults are derived from three embryonic cells. Science 202: 56–58
Martin GR (1982) X-chromosome inactivation in mammals. Cell 29: 721–724
Matuszewski B (1982) Diptera I: Cecidomyiidae. In: John B (ed) Animal cytogenetics, vol III. Insecta 3. Borntraeger, Berlin, pp 1–140
McCarthy BJ, Hoyer BH (1964) Identity of DNA and diversity of messenger RNA molecules in normal mouse tissues. Proc Natl Acad Sci USA 52: 915–922
McClintock B (1967) Genetic systems regulating gene expression during development. Dev Biol Suppl 1: 84–112
McLaren A (1981) Germ cells and soma: a new look at an old problem. Yale Univ Press, New Haven, pp 1–119
McLaren A, Wylie CC (1983) Current problems in germ cell differentiation. Cambridge Univ Press, Cambridge, pp 1–401
McTavish C, Sommerville J (1980) Macronuclear DNA organization and transcription in Paramecium primaurelia. Chromosoma 78: 147–164
Metz CW (1938) Chromosome behavior, inheritance and sex determination in Sciara. Am Nat 72: 485–520
Metz CW, Lawrence EG (1938) Preliminary observations on Sciara hybrids. J Hered 29: 179–186
Meyer GF, Lipps HJ (1980) Chromatin elimination in the hypotrichous ciliate Stylonychia mytilus. Chromosoma 77: 285–297
Meyer O (1895) Celluläre Untersuchungen an Nematoden-Eiern. Jena Z Naturwiss 29: 391–410
Mintz B (1962) Formation of genotypically mosaic mouse embryos. Am Zool 2: 432
Moritz KB (1967a) Die Blastomerendifferenzierung für Soma and Keimbahn bei Parascaris equorum. I. Cytochemische und photometrische Untersuchungen. Wilhelm Roux ’ Arch Entwicklungsmech 159: 31–88
Moritz KB (1967b) Die Blastomerendifferenzierung für Soma und Keimbahn bei Parascaris equorum. II. Untersuchungen mittels UV-Bestrahlung und Zentrifugierung. Wilhelm Roux ’ Arch Entwicklungsmech 159: 203–266
Moritz K B (1970a) Quantitative aspects of chromosomal composition in Ascaris megalocephala. In: Wied GL, Bahr GF (eds) Introduction to quantitative cytochemistry, vol II. Academic Press, London New York, pp 57–75
Moritz KB (1970b) DNS-Variation im keimbahnbegrenzten Chromatin und autoradiographisehe Befunde zu seiner Funktion bei Parascaris equorum. Verh Dtsch Zool Ges 64: 36–42
Moritz KB (1977) Die Chromosomen von Ascaris in der Keimbahn und im embryonalen Soma. Verh Dtsch Zool Ges 1977: 290
Moritz KB (1984) Der molekulare Mechanismus der Chromatindiminution. Zugleich ein Beitrag zur Telomerorganisation und -dynamik. Verh Dtsch Zool Ges 1984 77: 197
Moritz KB, Bauer M (1984) Cytoplasmatische Bedingungen der Chromatindiminution bei Parascaris equorum. Verh Dtsch Zool Ges 77: 164
Moritz K B, Roth GE (1976) Complexity of germline and somatic DNA in Ascaris. Nature (London) 259: 55–57
Moritz KB, Roth GE (1978) Die mitochondriale DNA im Ei von Ascaris. Verh Dtsch Zool Ges 71: 231
Müller F, Walker P, Aeby P, Neuhaus H, Back E, Tobler H (1982a) Molecular cloning and sequence analysis of highly repetitive DNA sequences contained in the eliminated genome of Ascaris lumbricoides. In: Burger MM, Weber R (eds) Embryonic development, part A: Genetic aspects. Liss, New York, pp 127–138
Müller F, Walker P, Aeby P, Neuhaus H, Felder H, Back E, Tobler H (1982b) Nucleotide sequence of satellite DNA contained in the eliminated genome of Ascaris lumbricoides. Nucleic Acids Res 10: 7493–7510
Müntzing A (1949) Accessory chromosomes in Secale and Poo. Hereditas Suppl 35: 402–411
Murti KG, Prescott DM (1970) Micronuclear ribonucleic acid in Tetrahymena pyriformis. J Cell Biol 47: 460–467
Mutafova T (1975) Morphology and behaviour of sex chromosomes during meiosis in Ascaris suum. Z Parasitenkd 46: 291–295
Nagt W (1976) Zellkern und Zellzyklen. Ulmer, Stuttgart, pp 1–486
Nagl W (1978) Endopolyploidy and polyteny in differentiation and evolution. Elsevier/NorthHolland, Amsterdam, pp 1–283
Nagt W (1983) Heterochromatin elimination in the orchid Dendrobium. Protoplasma 118: 234–237
Nelson-Rees WA, Hoy MA, Roush RT (1980) Heterochromatinization, chromatin elimination and haploidization in the parahaploid mite Metaseiulus occidentalis (Nesbitt) ( Acarina: Phytoseiidae). Chromosoma 77: 263–276
Nicklas RB (1959) An experimental and descriptive study of chromosome elimination in Miastor spec. (Cecidomyidae; Diptera). Chromosoma 10: 301–336
Nicklas RB (1960) The chromosome cycle of a primitive Cecidomyiid Mycophila speyeri. Chromosoma 11: 402–418
Nieuwkoop PD, Sutasurya LA (1979) Primordial germ cells in the chordates. Cambridge Univ Press, Cambridge, pp 1–187
Nieuwkoop PD, Sutasurya LA (1981) Primordial germ cells in the invertebrates. Cambridge Univ Press, Cambridge, pp 1–258
Nigon V (1965) Développement et reproduction des Nématodes. In: Grassé PP (ed) Traité de zoologie, vol IV. Masson, Paris, pp 218–386
Nigon V, Guerrier P, Monin H (1960) L’architecture polaire de l’oeuf et les mouvements des constituants cellulaires au cours des premières étapes du développement chez quelques Nématodes. Bull Biol Fr Belg 94: 131–202
Noda K, Kanai C (1977) An ultrastructural observation on Pelmatohydra robusta at sexual and asexual stages, with a special reference to “germinal plasm”. J Ultrastruct Res 61.284–294
Noll F, Bielka H (1968) Zur Biochemie der Embryogenese von Ascaris I. Gehalt und Verteilungsmuster der Nukleinsäuren. Acta Biol Med Germ 20: 565–575
Nur U (1980) Evolution of unusual chromosome systems in scale insects (Coccoidea: Homoptera). In: Blackman RL, Hewitt GM, Ashburner M (eds) Insect cytogenetics. Blackwell Sci Publ, Oxford, pp 97–117
Nussbaum M (1880) Zur Differenzierung des Geschlechts im Thierreich. Arch Mikrosk Anat Entwicklungsmech 18: 1–120
Okada TS (1983) Recent progress in studies of the transdifferentiation of eye tissue in vitro. Cell Differ 13: 177–183
Painter TS (1945) Chromatin diminution. Trans Conn Acad Arts Sci 36: 443–448
Painter TS (1966) The role of the E-chromosomes in Cecidomyiidae. Proc Natl Acad Sci USA 56: 853–855
Painter TS, Stone W (1935) Chromosome fusion and speciation in Drosophilae. Genetics 20: 327–341
Pasteels J (1948 a) Etude cytochimique des acides nucléiques dans le cycle germinal de l’Ascaris megalocephala Experientia 4:150–152
Pasteels J (1948 b) Recherches sur le cycle germinal chez l’Ascaris Etude cytochimique des acides nucléiques dans l’oögénèse, la spermatogénèse et le développement chez Parascaris eyuorum Goerze. Arch Biol 59:405–446
Pasternak J, Barrell R (1976) Quantitation of nuclear DNA in Ascaris lumbricoides: DNA constancy and chromatin diminution. Genet Res Cambridge 27: 339–348
Radzikowski S (1973) Die Entwicklung des Kernapparates und die Nukleinsäuresynthese während der Konjugation von Chilodonella cucullulus O. F. Müller. Arch Protistenkd 115: 419–428
Reitberger A (1934) Das Verhalten der Chromosomen bei der pädogenetischen Entwicklung der Cecidomyide Oligarces paradoxus, mit besonderer Berücksichtigung der Chromosomen-Elimination. Verh Schweiz Naturforsch Ges 115: 359–360
Reitberger A (1940) Die Cytologie des pädagenetischen Entwicklungszyklus der Gallmücke Oligarces paradoxus Mein. Chromosoma 1: 391–473
Rempel JG, Church NS (1969) The embryology of Lytta viridana Le Conte ( Coleoptera: Meloidae) IV. Chromatin elimination. Can J Zool 47: 351–353
Rieger R, Michaelis A, Green MM (1968) A glossary of genetics and cytogenetics. Springer, Berlin Heidelberg New York, pp 1–507
Ris H, Kleinfeld R (1952) Cytochemical studies on the chromatin elimination in Solenobia ( Lepidoptera ). Chromosoma 5: 363–371
Ritossa FM (1968) Unstable redundancy of genes for ribosomal RNA. Proc Natl Acad Sci USA 60: 509–516
Rosenzweig B, Liao LW, Hirsh D (1983 a) Sequence of the C. elegans transposable element Tel. Nucleic Acids Res 11: 4201–4209
Rosenzweig B, Liao LW, Hirsh D (1983 b) Target sequences for the C. elegans transposable element Tel. Nucleic Acids Res 11: 7137–7140
Roth GE (1979) Satellite DNA properties of the germ line limited DNA and the organization of the somatic genomes in the nematodes Ascaris suum and Parascaris equorum. Chromo-soma 74: 355–371
Roth GE, Moritz KB (1981) Restriction enzyme analysis of the germ line limited DNA of Ascaris suum. Chromosoma 83: 169–190
Ruan K, Emmons SW (1984) Extrachromosomal copies of transposon Tel in the nematode Caenorhabditis elegans. Proc Natl Acad Sci USA 81: 4018–4022
Sang JH (1984) Genetics and development. Longman, London, pp 1–398
Scarano E, Iaccarino M, Grippo P, Parisi F (1967) The heterogeneity of thymine methyl group origin in DNA pyrimidine isostichs of developing sea urchin embryos. Proc Natl Acad Sci USA 57: 1394–1400
Schachat F, O’Connor DJ, Epstein HF (1978) The moderately repetitive DNA sequences of Caenorhanditis elegans do not show short-period interspersion. Biochim Biophys Acta 520: 688–692
Schimke RT, Alt FW, Kellems RE, Kaufman RJ, Bertino JR (1978) Amplification of folate reductase genes in methotrexate-resistant cultured mouse cells. Cold Spring Harbor Symp Quant Biol 42: 649–657
Schleip W (1923) Die Wirkung des ultravioletten Lichtes auf die morphologischen Bestandteile des Ascariseies. Arch Zellforsch 17: 289–367
Schmid V, Alder H (1984) Isolated mononucleated, striated muscle can undergo pluripotent transdifferentiation and form a complex regenerate. Cell 38: 801–809
Schrader F (1935) Notes on the mitotic behavior of long chromosomes. Cytologia 6: 422–430
Schwartz V, Meister H (1975) Die Extinktion der feulgengefärbten Makronucleusanlage von Paramaecium bursaria in der DNS-armen Phase. Arch Protistenkd 117: 60–64
Searcy DG, MacInnis AJ (1970) Measurements by DNA renaturation of the genetic basis of parasitic reduction. Evolution 24: 796–806
Seiler J (1914) Das Verhalten der Geschlechtschromosomen bei Lepidopteren. Arch Zellforsch 13: 159–269
Shapiro JA (1983) Mobile genetic elements. Academic Press, London New York, pp 1–688
Singer MF (1982) Highly repeated sequenes in mammalian genomes. Int Rev Cytol 76: 67–112
Slack JMW (1983) From egg to embryo: Determinative events in early development. Cambridge Univ Press, Cambridge, pp 1–241
Smith LD (1966) The role of a “germinal plasm” in the formation of primordial germ cells in Rana pipiens. Dev Biol 14: 330–347
Sonneborn TM (1974) Paramecium aurelia. In: King RC (ed) Handbook of genetics, vol II. Plenum Press, New York, pp 469–594
Sonnenblick BP (1965) The early embryology of Drosophila melanogaster. In: Demerec M (ed) Biology of Drosophila. Hafner, New York, pp 62–167
Sorsa M, Suomalainen E (1975) Electron microscopy of chromatin elimination in Cidaria ( Lepidoptera ). Hereditas 80: 35–40
Spear BB, Gall JG (1973) Independent control of ribosomal gene replication in polytene chromosomes of Drosophila melanogaster. Proc Natl Acad Sci USA 70: 1359–1363
Spemann H (1903) Entwicklungsphysiologische Studien am Triton-Ei. II. Arch Entwicklungsmech Org 15: 448–534
Spradling AC, Mahowald AP (1980) Amplification of genes for chorion proteins during oogenesis in Drosophila melanogaster. Proc Natl Acad Sci USA 77: 1096–1100
Stanley HP, Kasinsky HE, Bols NC (1984) Meiotic chromatin diminution in a vertebrate, the holocephalan fish Hydrolagus colliei ( Chondrichthyes, Holocephali). Tissue Cell 16: 203–215
Stark GR, Wahl GM (1984) Gene amplification. Annu Rev Biochem 53: 447–491
Steinbrück G (1986) Molecular reorganization during nuclear differentiation in ciliates (this Vol)
Steinbrück G, Haas I, Hellmer KH, Ammermann D (1981) Characterization of macronuclear DNA in five species of Ciliates. Chromosoma 83: 199–208
Stevens NM (1909) The effect of ultraviolet-light upon the developing eggs of Ascaris megalocephala. Arch Entwicklungsmech Org 27: 622–639
Steward FC, Mapes MO, Kent AE, Holsten RD (1964) Growth and development of cultured plant cells. Science 143: 20–27
Strassen O zur (1896) Embryonalentwicklung der Ascaris megalocephala. Arch Entwicklungsmech 3:27–105, 133–190
Strassen O zur (1898) Über die Riesenbildung bei Ascariseiern. Arch Entwicklungsmech 7: 642–676
Strassen O zur (1906) Die Geschichte der T-Riesen von Ascaris megalocephala als Grundlage zu einer Entwicklungsmechanik dieser Spezies. Zoologica 40: 1–342
Streble H, Krauter D (1982) Das Leben im Wassertropfen, Mikroflora und Mikrofauna des Süßwassers. Franckh’sche Verlagshandlung, Keller u Cie, Stuttgart, pp 1–336
Streeck RE, Moritz KB, Beer K (1982) Chromatin diminution in Ascaris suum: nucleotide sequence of the eliminated satellite DNA. Nucleic Acids Res 10: 3495–3502
Strome S, Wood WB (1982) Immunofluorescence visualization of germ-line-specific cytoplasmic granules in embryos, larvae, and adults of Caenorhabditis elegans. Proc Nall Acad Sci USA 79: 1558–1562
Strome S, Wood WB (1983) Generation of asymmetry and segregation of germ-line granules in early C. elegans embryos. Cell 35: 15–25
Sturm KS, Taylor JH (1981) Distribution of 5-methylcytosine in the DNA of somatic and germ-line cells from bovine tissues. Nucleic Acids Res 9: 4537–4546
Sulston JE, Brenner S (1974) The DNA of Caenorhabditis elegans. Genetics 77: 95–104
Sulston JE, Schierenberg E, White JG, Thomson JN (1983) The embryonic cell lineage of the nematode Caenorhabditis elegans. Dev Biol 100: 64–119
Tadano M (1968) Nemathelminthes. In: Kumé M, Dan K (eds) Invertebrate embryology. Nolit, Belgrad, pp 159–191
Tanabe K, Kotani M (1974) Relationship between the amount of the “germinal plasm” and the number of primordial germ cells in Xenopus laevis. J Embryol Exp Morphol 31: 89–98
Tardent P (1978) Coelenterata, Cnidaria. In: Seidel F (ed) Morphogenese der Tiere. Fischer, Jena, pp 69–415
Tarkowski AK (1961) Mouse chimaeras developed from fused eggs. Nature (London) 190: 857–860
Tartof KD (1971) Increasing the multiplicity of ribosomal RNA genes in Drosophila melanogaster. Science 171: 294–297
Tartof KD (1975) Redundant genes. Annu Rev Genet 9: 355–385
Tchou S (1937) Une nouvelle race chinoise d’Ascaris megalocephala (type trivalens). C R Acad Sci: 1676–1677
Thomas C, Prasad RS (1980) Chromosome elimination in Ctenocephalides orientis ( Siphonaptera ). Cytobios 29: 109–114
Thomas HM, Pickering RA (1983) Chromosome elimination in Hordeum vulgare x H. hulbosum hybrids. 1. Comparison of stable and unstable amphidiploids. Theor Appl Genet 66: 135–140
Tobler H (1972) The problem of genetic identity of different cell types. In: Ursprung H (ed) Nucleic acid hybridization in the study of cell differentiation. Results and problems in cell differentiation, vol III. Springer, Berlin Heidelberg New York, pp 1 9
Tobler H (1975) Occurrence and developmental significance of gene amplification. In: Weber R (ed) The biochemistry of animal development, vol I11. Academic Press, London New York, pp 91–143
Tobler H (1976) Genetic difference between germ line and somatic DNA in Ascaris lumhricoides. In: Müller-Bérat N, Rosenfeld C, Tarin D, Viza D (eds) Progress in differentiation research. Elsevier/North-Holland, Amsterdam, pp 147–154
Tobler H, Gut C (1974) Mitochondrial DNA from 4-cell stages of Ascaris lumbricoides. J Cell Sci 16: 593–601
Tobler H, Smith KD, Ursprung H (1972) Molecular aspects of chromatin elimination in Ascaris lumbricoides. Dev Biol 27: 190–203
Tobler H, Zulauf E, Kuhn O (1974) Ribosomal RNA genes in germ line and somatic cells of Ascaris lumbricoides. Dev Biol 41: 218–223
Tobler H, Müller F, Back E, Aeby P (1985) Germ line — soma differentiation in Ascaris: A molecular approach. Experientia 41: 1311–1319
Tonegawa S (1983) Somatic generation of antibody diversity. Nature (London) 302: 575–581
Triantaphyllou AC (1971) Genetics and cytology. In: Zuckermann BM, Mai WF, Rohde RA (eds) Plant parasitic nematodes, vol II. Cytogenetics, host-parasite interactions and physiology. Academic Press, London New York, pp 1–34
Ubisch L von (1943) Über die Bedeutung der Diminution von Ascaris megalocephala. Acta Biotheor 7: 163–181
Ueda R, Okada M (1982) Induction of pole cells in sterilized Drosophila embryos by injection of subcellular fractions from eggs. Proc Natl Acad Sci USA 79: 6946–6950
Vanyushin BF, Tkacheva SG, Belozersky AN (1970) Rare bases in animal DNA. Nature (London) 225: 948–949
Vassilev I, Mutafova T (1974) Comparative studies on the karyotype of Ascaris suum and “Ascaris ovis”. Z Parasitenkd 43: 115–121
Vendrely R (1955) The deoxyribonucleic acid content of the nucleus. In: Chargaff E, Davidson JN (eds) The nucleic acids, vol II. Academic Press, London New York, pp 155–180
Vereiskaya VN (1975) A cytochemical study of the elimination chromatin in the silkworm (Bombyx mori L.) meiosis. Tsitologyia 17: 603–606
Wakahara M (1977) Partial characterization of “primordial germ cell-forming activity” localized in vegetal pole cytoplasm in anuran eggs. J Embryo) Exp Morphol 39: 221–233
Wakahara M (1978) Induction of supernumerary primordial germ cells by injecting vegetal pole cytoplasm into Xenopus eggs. J Exp Zool 203: 159–164
Wallace H, Morray J, Langridge WHR (1971) Alternative model for gene amplification. Nature (London) New Biol 230: 201–203
Walton AC (1917) The oogenesis and early embryology of Ascaris canis Werner. J Morphol 30: 527–603
Walton AC (1924) Studies on nematode gametogenesis. Z Zellen- Gewebel 1: 167–239
Walton AC (1959) Some parasites and their chromosomes. J Parasitol 45: 1–20
Walton AC (1974) Gametogenesis. In: Chitwood BG, Chitwood MB (eds) Introduction to hematology. Univ Park Press, Baltimore, pp 191–201
Waring GL, Allis CD, Mahowald AP (1978) Isolation of polar granules and the identification of polar granule-specific protein. Dev Biol 66: 197–206
Weismann A (1885) Die Continuität des Keimplasmas als Grundlage einer Theorie der Vererbung. Fischer, Jena
Weismann A (1892) Das Keimplasma. Eine Theorie der Vererbung. Fischer, Jena
Weiss MC, Green H (1967) Human-mouse hybrid cell lines containing partial complements of human chromosomes and functioning human genes. Proc Natl Acad Sci USA 58: 1104–1111
White MJD (1936) Chromosome cycle of Ascaris megalocephala. Nature (London) 137: 783
White MJD (1947) The cytology of the Cecidomyidae (Diptera) III. J Morphol 80: 1–24
White MJD (1950) Cytological studies on gall midges (Cecidomyidae). Univ Tex Publ 5007: 1–80
White MJD (1954) Animal cytology and evolution, 2nd edn. Cambridge Univ Press, Cambridge, pp 1–454
White MJD (1973) Animal cytology and evolution, 3rd edn. Cambridge Univ Press, Cambridge, pp 1–961
Whitington PMcD, Dixon KE (1975) Quantitative studies of germ plasm and germ cells during early embryogenesis of Xenopus laevis. J Embryol Exp Morphol 33: 57–74
Wilson EB (1896) The cell in development and inheritance, 1st edn. Macmillan, New York, pp 1371
Wilson EB (1925) The cell in development and heredity, 3rd edn. Macmillan, New York, pp 112–32
Wolf N, Priess J, Hirsh D (1983) Segregation of germline granules in early embryos of Caenorhabditis elegans: an electron microscopic analysis. J Embryol Exp Morphol 73: 297–306
Wolff E (1964) L’origine de la lignée germinale. Hermann, Paris, pp 1–370
Wood WB, Strome S, Laufer JS (1983) Localization and determination in embryos of Caenorhabditis elegans. In: Jeffery WR, Raff RA (eds) Time, space, and pattern in embryonic development. Liss, New York, pp 221–239
Yamada T, McDevitt DS (1984) Conversion of iris epithelial cells as a model of differentiation control. Differentiation 27: 1–12
Yamaguchi Y, Murakami K, Furusawa M, Miwa J (1983) Germline-specific antigens identified by monoclonal antibodies in the nematode Caenorhanditis elegans. Dev Growth Differ 25: 121–131
Yao MC, Gall JG (1979) Alteration of the Tetrahymena genome during nuclear differentiation. J Protozool 26: 10–13
Yao MC, Gorovsky MA (1974) Comparison of the sequences of macro-and micronuclear DNA of Tetrahymena pyriformis. Chromosoma 48: 1–18
Yao T, Pai S (1942) Heteropycnosis and chromatin diminution in Cosmocerca sp. Sci Rec Acad Sinica 1: 197–202
Zalokar M (1976) Autoradiographic study of protein and RNA formation during early development of Drosophila eggs. Dev Biol 49: 425–437
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Tobler, H. (1986). The Differentiation of Germ and Somatic Cell Lines in Nematodes. In: Hennig, W. (eds) Germ Line — Soma Differentiation. Results and Problems in Cell Differentiation, vol 13. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-39838-7_1
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