Skip to main content

Laborchemische Diagnostik und therapeutisches Drugmonitoring

  • Chapter
Psychiatrie und Psychotherapie

Auszug

Die Psychiatrie ist mehr als andere Bereiche der Medizin abhängig von der klinischen Untersuchung der Symptome; sie kann sich bisher nicht darauf verlassen, anhand von Laborbefunden eine Diagnose definitiv bestätigen oder auszuschließen zu können. Dennoch führte die zune Etablierung psychopharmakologischer Behandlungsstrategien und auch die wachsende Erkenntnis, dass zahlreiche organische Störungen psychische Symptome induzieren können dazu, dass he die psychiatrische Diagnostik verschiedene Laborparameter mit einbezieht.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 199.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Alderman J, Preskorn SH, Greenblatt DJ et al. (1997). Desipramine pharmacokinetics when coadministered with paroxetine or sertraline in extensive metabolizers. J Clin Psychopharmacol 17: 284–291

    Article  PubMed  CAS  Google Scholar 

  • Alvir JM, Lieberman JA (1994) Agranulocytosis: incidence and risk factors. J Clin Psychiatry 55(Suppl B): 137–138

    PubMed  Google Scholar 

  • Anger B, Heimpel H (1987) Makrozytose durch Alkohol und (oder) Medikamente. Dtsch Med Wochenschr 112: 1800–1802

    PubMed  CAS  Google Scholar 

  • Backman JT, Kivisto KT, Olkkola KT, Neuvonen PJ (1998) The area under the plasma concentration-time curve for oral midazolam is 400-fold larger during treatment with itraconazole than with rifampicin. Eur J Clin Pharmacol 54: 53–58

    Article  PubMed  CAS  Google Scholar 

  • Banger M, Olbrich HM, Fuchs S, Gastpar M (1995) Cost-effectiveness of syphilis screening in a clinical for general psychiatry. Nervenarzt 66: 49–53

    PubMed  CAS  Google Scholar 

  • Baumann P, Hiemke C, Ulrich S et al. (2004) The AGNP-TDM Expert Group Consensus Guidelines: therapeutic drug monitoring in Psychiatry. Pharmacopsychiatry 37: 1–23, 243–265

    Google Scholar 

  • Baumgartner A, Campos Barros A (1993) Thyroid hormones and depressive disorders-clinical overview and perspectives. Part 2: Thyroid hormones and the central nervous system-basic research. Nervenarzt 64: 11–20

    PubMed  CAS  Google Scholar 

  • Besag FM, Berry D (2006) Interactions between antiepileptic and antipsychotic drugs. Drug Saf 29: 95–118

    Article  PubMed  CAS  Google Scholar 

  • Blennow K, Vanmechelen E, Hampel H (2001) CSF total tau, Ab42 and phosphorylated tau protein as biomarkers for Alzheimer’s disease. Mol Neurobiology 24: 87–97

    Article  CAS  Google Scholar 

  • Bortolotti F, de Paolo G, Tagliaro F (2006) Carbohydrate-defivient transferring (CDT) as a marker of alcohol abuse: a critical review of the literature 2001–2005. J Chromatogr B Analyt Technol Biomed Life Sci 841: 96–109

    Article  PubMed  CAS  Google Scholar 

  • Bradbury MW, Deane R (1993) Permeability of the blood-brain barrier to lead. Neurotoxicology 14: 131–136

    PubMed  CAS  Google Scholar 

  • Buckley NA, McManus PR (2002) Fatal toxicity of serotoninergic and other antidepressant drugs: analysis of United Kingdom mortality data. BMJ 325: 1332–1333

    Article  PubMed  Google Scholar 

  • Carson D, Serpell M (1996) Choosing the best needle for diagnostic lumbar puncture. Neurology 47: 33–37

    PubMed  CAS  Google Scholar 

  • Chou WH, Yan FX, de Leon J et al. (2000) Extension of a pilot study: impact from the cytochrome P450 2D6 polymorphism on outcome and costs associated with severe mental illness. J Clin Psychopharmacol 20: 246–251

    Article  PubMed  CAS  Google Scholar 

  • Derenne JL, Baldessarini RJ (2005) Clozapine toxicity associated with smoking cessation: case report. Am J Ther 12: 469–471

    Article  PubMed  Google Scholar 

  • Dermietzel R, Krause D (1991) Molecular anatomy of the blood-brain barrier as defined by immunocytochemistry. Int Rev Cytol 127: 57–109

    Article  PubMed  CAS  Google Scholar 

  • Evans DA, Beckett LA, Field TS et al. (1997) Apolipoprotein E epsilon4 and incidence of Alzheimer disease in a community population of older persons. JAMA 227: 822–824

    Article  Google Scholar 

  • Fagan AM, Watson M, Parsadanian M et al. (2002) Human and murine ApoE markedly alters Abeta metabolism before and after plaque formation in a mouse model of Alzheimer’s disease. Neurobiol Dis 9: 305–318

    Article  PubMed  CAS  Google Scholar 

  • Felgenhauer K (1992) Barrier concepts and CSF analysis [news]. J Neurol 239: 59–60

    Article  PubMed  CAS  Google Scholar 

  • Fisher DA (1996) Physiological variations in thyroid hormones: physiological and pathophysiological considerations. Clin Chem 42: 135–139

    PubMed  CAS  Google Scholar 

  • Gilbert JR, Evans CE, Haynes RB, Tugwell P (1980) Predicting compliance with a regimen of digoxin therapy in family practice. Can Med Assoc J 123: 119–122

    PubMed  CAS  Google Scholar 

  • Gilg T, Soyka M (1997) Wertigkeit biologischer Marker für Alkoholabusus und Alkoholismus. Nervenheilk 16: 362–371

    Google Scholar 

  • Gsponer J, Vendruscolo M (2006) Theoretical approaches to protein aggregation. Protein Pept Lett 13: 287–293

    Article  PubMed  CAS  Google Scholar 

  • Hampel H, Buerger K, Zinkowsky R et al. (2004) Measurement of phosphorylated Tau epitopes in the differential diagnosis of Alzheimer Disease. Arch Gen Psychiatry 61: 95–102

    Article  PubMed  CAS  Google Scholar 

  • Herbay A von, Strohmeyer G (1994) Die erhöhte g-GT. Ursachen und Interpretationen. Dtsch Med Wochenschr 119/30: 1041–1044

    Article  Google Scholar 

  • Hiemke C, Dragicevic A, Grunder G et al. (2004) Therapeutic monitoring of new antipsychotic drugs. Ther Drug Monit 26: 156–160

    Article  PubMed  CAS  Google Scholar 

  • Hiemke C, Baumann P, Laux G et al (2005) Therapeutisches Drug Monitoring in der Psychiatrie. Konsensus-Leitlinie der AGNP. Psychopharmakotherapie 12: 166–182

    Google Scholar 

  • Hoffman PL, Iorio KR, Snell LD, Tabakoff B (1995) Attenuation of glutamate-induced neurotoxicity in chronically ethanol-exposed cerebellar granule cells by NMDA receptor antagonists and ganglioside GM1. Alcohol Clin Exp Res 19: 721–726

    Article  PubMed  CAS  Google Scholar 

  • Huang Y (2006) Apolipoprotein E and Alzheimer Disease. Neurology 66(Suppl1): 79–85

    Google Scholar 

  • Kaiser R, Czygan M, Kaufmann R, Lucking CH (1995) Intrathekale IgGSynthese: Wann ist eine Bestimmung der oligoklonalen Banden erforderlich? Nervenarzt 66: 618–623

    PubMed  CAS  Google Scholar 

  • Keffer JH (1996) Preanalytical considerations in testing thyroid function [see comments]. Clin Chem 42: 125–134

    PubMed  CAS  Google Scholar 

  • Klimke A, Klieser E (1995) Das atypi sche Neuroleptikum Clozapin (Leponex)-aktueller Kenntnisstand und neuere klinische Aspekte. Fortschr Neurol Psychiatr 63: 173–193

    Article  PubMed  CAS  Google Scholar 

  • Kirchheiner J, Fuhr U, Brockmoller J (2005) Pharmacogenetics-based therapeutic recommendations-ready for clinical practice? Nat Rev Drug Discov 4: 639–647

    Article  PubMed  CAS  Google Scholar 

  • Lane HY, Chang YC, Chang WH et al. (1999) Effects of gender and age on plasma levels of clozapine and its metabolites: analyzed by critical statistics. J Clin Psychiatry 60: 36–40

    Article  PubMed  CAS  Google Scholar 

  • Li KY, Li X, Cheng ZN et al. (2005) Effect of erythromycin on metabolism of quetiapine in Chinese suffering from schizophrenia. Eur J Clin Pharmacol 60: 791–795

    Article  PubMed  CAS  Google Scholar 

  • Linder MW, Keck PE Jr (1998) Standards of laboratory practice: antidepressant drug monitoring. National Academy of Clinical Biochemistry. Clin Chem 44: 1073–1084

    PubMed  CAS  Google Scholar 

  • Lingam R, Scott J (2002) Treatment non-adherence in affective disorders. Acta Psychiatr Scand 105: 164–172

    Article  PubMed  Google Scholar 

  • Lundmark J, Bengtsson F, Nordin C (2000) Therapeutic drug monitoring of selective serotonin reuptake inhibitors influences clinical dosing strategies and reduces drug costs in depressed elderly patients. Acta Psychiatr Scand 101: 354–359

    Article  PubMed  CAS  Google Scholar 

  • Matthes A, Kruse R (2003) Pharmakotherapie der Epilepsien, 17. Aufl. Hrsg: Deutsche Sektion der Internationalen Liga gegen Epilepsie

    Google Scholar 

  • Mayeux R (1996) Development of a national prospective study of Alzheimer disease. Alzheimer Dis Assoc Disord 10(Suppl 1): 38–44

    Article  PubMed  Google Scholar 

  • McMillan SA, Douglas JP, Droogan AG, Hawkins SA (1996) Evaluation of formulae for CSF IgG synthesis using data obtained from two methods: importance of receiver operator characteristic curve analysis. J Clin Pathol 49: 24–28

    Article  PubMed  CAS  Google Scholar 

  • Mihas AA, Tavassoli M (1992) Laboratory markers of ethanol intake and abuse. A critical appraisal. Am J Med Sci 303: 415–428

    Article  PubMed  CAS  Google Scholar 

  • Miller DD (1996) The clinical use of clozapine plasma concentrations in the management of treatment-refractory schizophrenia. Ann Clin Psychiatry 8: 99–109

    Article  PubMed  CAS  Google Scholar 

  • Miller PM, Spies C, Neumann et al. (2006) Alcohool Biomarker Screenings in Medical and Surgical Settings. Alcoholism Clin Exper Res 30: 185–193

    Article  Google Scholar 

  • Mitchell PB (2004) Therapeutic drug monitoring of non-tricyclic antidepressant drugs. Clin Chem Lab Med 42: 1212–1218

    Article  PubMed  CAS  Google Scholar 

  • Naranjo CA, Herrmann N, Mittmann N, Bremner KE (1995) Recent advances in geriatric psychopharmacology. Drugs Aging 7: 184–202

    Article  PubMed  CAS  Google Scholar 

  • Ng CH, Schweitzer I, Norman T, Easteal S (2004) The emerging role of pharmacogenetics: implications for clinical psychiatry. Aust N Z J Psychiatry 38: 483–489

    Article  PubMed  Google Scholar 

  • Nieman EA (1997) Neurosyphilis yesterday and today [see comments]. J R Coll Physicians Lond 25: 321–324

    Google Scholar 

  • Nose M, Barbui C, Tansella M (2003) How often do patients with psychosis fail to adhere to treatment programmes? A systematic review. Psychol Med 33: 1149–1160

    Article  PubMed  CAS  Google Scholar 

  • Ovsiew F (2004) Antiepileptic drugs in psychiatry. J Neurol Neurosur Psychiat 75: 1655–1658

    Article  CAS  Google Scholar 

  • Pennell PB (2003) Antiepileptic drug pharmacokinetics during pregnancy and lactation. Neurology 61: S35–S42

    PubMed  CAS  Google Scholar 

  • Perry PJ, Zeilmann C, Arndt S (1994) Tricyclic antidepressant concentrations in plasma: an estimate of their sensitivity and specificity as a predictor of response. J Clin Psychopharmacol 14: 230–240

    Article  PubMed  CAS  Google Scholar 

  • Perry PJ, Lund BC, Sanger T, Beasley C (2001) Olanzapine plasma concentrations and clinical response: acute phase results of the North American Olanzapine Trial. J Clin Psychopharmacol 21: 14–20

    Article  PubMed  CAS  Google Scholar 

  • Preskorn SH, Fast GA (1991) Therapeutic drug monitoring for antidepressants: efficacy, safety, and cost effectiveness. J Clin Psychiatry 52(Suppl): 23–33

    PubMed  Google Scholar 

  • Reiber H (1994) Flow rate of cerebrospinal fluid (CSF)-a concept common to normal blood-CSF barrier function and to dysfunction in neurological diseases [see comments]. J Neurol Sci 122: 189–203

    Article  PubMed  CAS  Google Scholar 

  • Reiber H (1995) External quality assessment in clinical neurochemistry: survey of analysis for cerebrospinal fluid (CSF) proteins based on CSF/serum quotients. Clin Chem 41: 256–263

    PubMed  CAS  Google Scholar 

  • Reiber H, Felgenhauer K (1987) Protein transfer at the blood cerebrospinal fluid barrier and the quantitation of the humoral immune response within the central nervous system. Clin Chim Acta 163: 319–328

    Article  PubMed  CAS  Google Scholar 

  • Raaska K, Raitasuo V, Laitila J, Neuvonen PJ (2004) Effect of caffeinecontaining versus decaffeinated coffee on serum clozapine concentrations in hospitalised patients. Basic Clin Pharmacol Toxicol 94: 13–18

    Article  PubMed  CAS  Google Scholar 

  • Reis M, Lundmark J, Bengtsson F (2003) Therapeutic drug monitoring of racemic citalopram: a 5-year experience in Sweden, 1992–1997. Ther Drug Monit 25: 183–191

    Article  PubMed  CAS  Google Scholar 

  • Rogers SL, Friedhoff LT (1996) The efficacy and safety of donepezil in patients with Alzheimer’s disease: results of a US Multicentre, Randomized, Double-Blind, Placebo-Controlled Trial. The Donepezil Study Group. Dementia 7: 293–303

    PubMed  CAS  Google Scholar 

  • Roh HK, Chung JY, Oh DY et al. (2001) Plasma concentrations of haloperidol are related to CYP2D6 genotype at low, but not high doses of haloperidol in Korean schizophrenic patients. Br J Clin Pharmacol 52: 265–271

    Article  PubMed  CAS  Google Scholar 

  • Schmidt LG, Schmidt K, Dufeu P et al. (1997) Superiority of carbohydrate-deficient transferrin to gamma-glutamyltransferase in detecting relapse in alcoholism. Am J Psychiatry 154: 75–80

    PubMed  CAS  Google Scholar 

  • Schulz M, Schmoldt A (2003) Therapeutic and toxic blood concentrations of more than 800 drugs and other xenobiotics. Pharmazie 58: 447–474

    PubMed  CAS  Google Scholar 

  • Seitz HK, Lieber CS, Simanowski U (1995) Handbuch Alkohol, Alkoholismus, alkoholbedingte Organschäden. JA Barth, Leipzig Heidelberg

    Google Scholar 

  • Severus WE, Grunze H, Kleindienst N et al. (2005) Is the prophylactic antidepressant efficacy of lithium in bipolar I disorder dependent on study design and lithium level? J Clin Psychopharmacol 25:457–462

    Article  PubMed  CAS  Google Scholar 

  • Shen WW (1997) The metabolism of psychoactive drugs: a review of enzymatic biotransformation and inhibition. Biol Psychiatry 41: 814–826

    Article  PubMed  CAS  Google Scholar 

  • Sillanaukee P (1996) Laboratory markers of alcohol abuse. Alcohol Alcohol 31: 613–616

    PubMed  CAS  Google Scholar 

  • Sjogren M, Vanderstichele H, Agren H et al. (2001) Tau and Abeta42 in cerebrospinal fluid from healthy adults 21–93 years of age: establishment of reference values. Clin Chem 47: 1776–1781

    PubMed  CAS  Google Scholar 

  • Sorvajarvi K, Blake JE, Israel Y, Niemela O (1996) Sensitivity and specificity of carbohydrate-deficient transferrin as a marker of alcohol abuse are significantly influenced by alterations in serum transferrin: comparison of two methods. Alcohol Clin Exp Res 20: 449–454

    Article  PubMed  CAS  Google Scholar 

  • Tanzi R, Gaston S, Bush A et al. (1993) Genetic heterogeneity of gene defects responsible for familial Alzheimer disease. Genetica 91: 255–263

    Article  PubMed  CAS  Google Scholar 

  • Taylor D, Lader M (1996) Cytochromes and psychotropic drug interactions [editorial]. Br J Psychiatry 168: 529–532

    Article  PubMed  CAS  Google Scholar 

  • Thal DR, Capetillo-Zarate E, Del Tredici K, Braak H (2006) The Development of amyloid beta protein deposits in the aged brain. Sci Aging Knowledge Environ 6: re1

    Article  Google Scholar 

  • Thomas L (1993) Labor und Diagnose. Die Medizinische Verlagsgruppe, Marburg

    Google Scholar 

  • Timmer RT, Sands JM (1999) Lithium intoxication. J Am Soc Nephrol 10: 666–674

    PubMed  CAS  Google Scholar 

  • Umbricht D, Kane JM (1996) Medical complications of new antipsychotic drugs. Schizophr Bull 22: 475–483

    PubMed  CAS  Google Scholar 

  • Walts AE, Strigle S (1995) Toward optimal use of the cytology laboratory: quality improvement and cerebrospinal fluid specimens. Diagn Cytopathol 13: 357–361

    Article  PubMed  CAS  Google Scholar 

  • Watson RR (1989) Diagnosis of alcohol abuse. CRC Press, Boca Raton/FL

    Google Scholar 

  • Williams KC, Ulvestad E, Hickey WF (1994) Immunology of multiple sclerosis. Clin Neurosci 2: 229–245

    PubMed  CAS  Google Scholar 

  • Wurst FM, Alling C, Aradottir S et al (2005) Emerging biomarkers: new directions and clinical applications. Alcohol Clin Exp Res 29: 456–473

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer Medizin Verlag Heidelberg

About this chapter

Cite this chapter

Bondy, B., Schwarz, M.J. (2008). Laborchemische Diagnostik und therapeutisches Drugmonitoring. In: Möller, HJ., Laux, G., Kapfhammer, HP. (eds) Psychiatrie und Psychotherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-33129-2_23

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-33129-2_23

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-24583-4

  • Online ISBN: 978-3-540-33129-2

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics