Skip to main content

Neurotransmitters in the Auditory System

  • Reference work entry
  • First Online:
Encyclopedia of Neuroscience

Synonyms

Excitatory and inhibitory neurotransmission at synapses in the central auditory system and cochlea

Definition

In the auditory (hearing) system, as in other parts of the nervous system, neurotransmitters are chemicals that cross a synapse and mediate nerve impulse transmission from one neuron to the next neuron, or from sensory cells (hair cells in the cochlea of the inner ear) to neurons, or from neurons to effector cells (in this case, the same sensory hair cells of the cochlea). Neurotransmitters typically excite or inhibit the neuron to enhance or reduce nerve impulse transmission, but they can also mediate long-term changes in the neuron, including maturation and learning. All of these functions involve interplay of different neurotransmitters, with some kinds modulating the effects of other kinds, to shape the response. For the auditory system, this results in accurate sound identification and localization, and the integration of audition with other sensory modalities and...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

References

  1. Pollak GD, Burger RM, Klug A (2003) Dissecting the circuitry of the auditory system. Trends Neurosci 26:33–39

    Article  CAS  PubMed  Google Scholar 

  2. Malmierca MS, Merchán MA (2004) Auditory system. In: Paxinos G (ed) The rat nervous system, 3rd edn. Elsevier Academic, New York, pp 997–1082

    Chapter  Google Scholar 

  3. Wenthold RJ, Hunter C (1990) Immunocytochemistry of glycine and glycine receptors in the central auditory system. In: Ottersen OP, Storm-Mathisen J (eds) Glycine Neurotransmission. Wiley, New York, pp 391–416

    Google Scholar 

  4. Rubio ME (2004) Differential distribution of synaptic endings containing glutamate, glycine, and GABA in the rat dorsal cochlear nucleus. J Comp Neurol 477:253–272

    Article  CAS  PubMed  Google Scholar 

  5. Kanold PO, Young ED (2001) Proprioceptive information from the pinna provides somatosensory input to cat dorsal cochlear nucleus. J Neurosci 21:7848–7858

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Winer JA, Larue DT (1996) Evolution of GABAergic circuitry in the mammalian medial geniculate body. Proc Natl Acad Sci USA 93:3083–3087

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Wenthold RJ, Hunter C, Petralia RS, Niedzielski AS, Wang Y-X, Safieddine S, Zhao H-M, Rubio ME (1997) Receptors in the auditory pathways. In: Berlin CI (ed) Neurotransmission and hearing loss: basic science, diagnosis, and management. Singular, San Diego, pp 1–23

    Google Scholar 

  8. Petralia RS, Rubio ME, Wang Y-X, Wenthold RJ (2000) Differential distribution of glutamate receptors in the cochlear nuclei. Hear Res 147:59–69

    Article  CAS  PubMed  Google Scholar 

  9. Srinivasan G, Friauf E, Löhrke S (2004) Functional glutamatergic and glycinergic inputs to several superior olivary nuclei of the rat revealed by optical imaging. Neuroscience 128:617–634

    Article  CAS  PubMed  Google Scholar 

  10. Wenthold RJ, Hunter C, Petralia RS (1993) Excitatory amino acid receptors in the rat cochlear nucleus. In: Merchan MA, Juiz JM, Godfrey DA, Mugnaini E (eds) The mammalian cochlear nuclei: organization and function. Plenum, New York, pp 179–194

    Chapter  Google Scholar 

  11. Joshi I, Shokralla S, Titis P, Wang L-Y (2004) The role of AMPA receptor gating in the development of high-fidelity neurotransmission at the calyx of Held synapse. J Neurosci 24:183–196

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Wong H-K, Liu X-B, Matos MF, Chan SF, Pérez-Otaño I, Boysen M, Cui J, Nakanishi N, Trimmer JS, Jones EG, Lipton SA, Sucher NJ (2002) Temporal and regional expression of NMDA receptor subunit NR3A in the mammalian brain. J Comp Neurol 450:303–317

    Article  CAS  PubMed  Google Scholar 

  13. Safieddine S, Wenthold RJ (1997) The glutamate receptor subunit δ1 is highly expressed in hair cells of the auditory and vestibular systems. J Neurosci 17:7523–7531

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Lioudyno MI, Verbitsky M, Glowatzki E, Holt JC, Boulter J, Zadina JE, Elgoyhen AB, Guth PS (2002) The α9/α10-containing nicotinic ACh receptor is directly modulated by opioid peptides, endomorphin-1, and dynorphin B, proposed efferent cotransmitters in the inner ear. Mol Cell Neurosci 20:695–711

    Article  CAS  PubMed  Google Scholar 

  15. Happe HK, Morley BJ (2004) Distribution and postnatal development of α7 nicotinic acetylcholine receptors in the rodent lower auditory brainstem. Dev Brain Res 153:29–37

    Article  CAS  Google Scholar 

  16. Metherate R, Hsieh CY (2004) Synaptic mechanisms and cholinergic regulation in auditory cortex. Prog Brain Res 145:143–156

    Article  CAS  PubMed  Google Scholar 

  17. Skinner RD, Homma Y, Garcia-Rill E (2004) Arousal mechanisms related to posture and locomotion: 2. Ascending modulation. Prog Brain Res 143:291–298

    Article  PubMed  Google Scholar 

  18. Maison SF, Adams JC, Liberman MC (2003) Olivocochlear innervation in the mouse: immunocytochemical maps, crossed versus uncrossed contributions, and transmitter colocalization. J Comp Neurol 455:406–416

    Article  CAS  PubMed  Google Scholar 

  19. Turecek R, Trussell LO (2002) Reciprocal developmental regulation of presynaptic ionotropic receptors. Proc Natl Acad Sci USA 99:13884–13889

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Awatramani GB, Turecek R, Trussell LO (2005) Staggered development of GABAergic and glycinergic transmission in the MNTB. J Neurophysiol 93:819–828

    Article  CAS  PubMed  Google Scholar 

  21. Gillespie DC, Kim G, Kandler K (2005) Inhibitory synapses in the developing auditory system are glutamatergic. Nat Neurosci 8:332–338

    Article  CAS  PubMed  Google Scholar 

  22. Behrens EG, Schofield BR, Thompson AM (2002) Aminergic projections to cochlear nucleus via descending auditory pathways. Brain Res 955:34–44

    Article  CAS  PubMed  Google Scholar 

  23. Thompson AM (2003) A medullary source of norepinephrine in cat cochlear nuclear complex. Exp Brain Res 153:486–490

    Article  PubMed  Google Scholar 

  24. Thompson AM, Hurley LM (2004) Dense Serotonergic innervation of principal nuclei of the superior olivary complex in mouse. Neurosci Lett 356:179–182

    Article  CAS  PubMed  Google Scholar 

  25. von Gersdorff H, Borst JGG (2001) Short-term plasticity at the calyx of Held. Nat Rev Neurosci 3:53–64

    Article  Google Scholar 

  26. Gil-Loyzaga P, Bartolomé V, Vicente-Torres A, Carricondo F (2000) Serotonergic innervation of the organ of Corti. Acta Otolaryngol 120:128–132

    Article  CAS  PubMed  Google Scholar 

  27. Wynne B, Robertson D (1997) Somatostatin and substance P-like immunoreactivity in the auditory brainstem of the adult rat. J Chem Neuroanat 12:259–266

    Article  CAS  PubMed  Google Scholar 

  28. Robertson D, Mulders WHAM (2000) Distribution and possible functional roles of some neuroactive peptides in the mammalian superior olivary complex. Microsc Res Tech 51:307–317

    Article  CAS  PubMed  Google Scholar 

  29. Martín F, Coveñas R, Narváez JA, Tramu G (2003) An immunocytochemical mapping of somatostatin in the cat auditory cortex. Arch Ital Biol 141:157–170

    PubMed  Google Scholar 

  30. Yukawa H, Shen J, Harada N, Cho-Tamaoka H, Yamashita T (2005) Acute effects of glucocorticoids on ATP-induced Ca2+ mobilization and nitric oxide production in cochlear spiral ganglion neurons. Neuroscience 130:485–496

    Article  CAS  PubMed  Google Scholar 

  31. Kimura M, Saitoh N, Takahashi T (2003) Adenosine A1 receptor-mediated inhibition at the calyx of Held of immature rats. J Physiol 553.2:415–426

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer-Verlag GmbH Berlin Heidelberg

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Petralia, R.S., Wenthold, R.J. (2009). Neurotransmitters in the Auditory System. In: Binder, M.D., Hirokawa, N., Windhorst, U. (eds) Encyclopedia of Neuroscience. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29678-2_3957

Download citation

Publish with us

Policies and ethics