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Mesenchymal Stem Cells as Endogenous Regulators of Inflammation

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Stromal Immunology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1060))

Abstract

This chapter discusses the regulatory role of endogenous mesenchymal stem cells (MSC) during an inflammatory response. MSC are a heterogeneous population of multipotent cells that normally contribute towards tissue maintenance and repair but have garnered significant scientific interest for their potent immunomodulatory potential. It is through these physicochemical interactions that MSC are able to exert an anti-inflammatory response on neighbouring stromal and haematopoietic cells. However, the impact of the chronic inflammatory environment on MSC function remains to be determined. Understanding the relationship of MSC between resolution of inflammation and autoimmunity will both offer new insights in the use of MSC as a therapeutic, and also their involvement in the pathogenesis of inflammatory disorders.

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Conflicts of Interest

The authors declare that they have no conflicts of interest.

Funding

HM and LSCW were supported by BBSRC and MRC PhD studentships, respectively. HMM was supported by an Arthritis Research UK Career Development Fellowship (19899) and Systems Science for Health, University of Birmingham (5212).

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Author notes

  1. Hafsa Munir and Lewis S. C. Ward have contributed equally to this work

Authors and Affiliations

  1. MRC Cancer Unit/Hutchison, University of Cambridge, Cambridge, UK

    Hafsa Munir

  2. Discovery Sciences, AstraZeneca, Cambridge, UK

    Lewis S. C. Ward

  3. Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK

    Helen M. McGettrick

Authors
  1. Hafsa Munir
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  2. Lewis S. C. Ward
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  3. Helen M. McGettrick
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Editors and Affiliations

  1. Somerville College, University of Oxford, Oxford, UK

    Benjamin M.J Owens

  2. F-star Biotechnology Ltd., Cambridge, UK

    Matthew A. Lakins

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Munir, H., Ward, L.S.C., McGettrick, H.M. (2018). Mesenchymal Stem Cells as Endogenous Regulators of Inflammation. In: Owens, B., Lakins, M. (eds) Stromal Immunology. Advances in Experimental Medicine and Biology, vol 1060. Springer, Cham. https://doi.org/10.1007/978-3-319-78127-3_5

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