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Natural Origin Materials for Osteochondral Tissue Engineering

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Osteochondral Tissue Engineering

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1058))

Abstract

Materials selection is a critical aspect for the production of scaffolds for osteochondral tissue engineering. Synthetic materials are the result of man-made operations and have been investigated for a variety of tissue engineering applications. Instead, the products of physiological processes and the metabolic activity of living organisms are identified as natural materials. Over the recent decades, a number of natural materials, namely, biopolymers and bioceramics, have been proposed as the main constituent of osteochondral scaffolds, but also as cell carriers and signaling molecules. Overall, natural materials have been investigated both in the bone and in the cartilage compartment, sometimes alone, but often in combination with other biopolymers or synthetic materials. Biopolymers and bioceramics possess unique advantages over their synthetic counterparts due similarity with natural extracellular matrix, the presence of cell recognition sites and tunable chemistry. However, the characteristics of natural origin materials can vary considerably depending on the specific source and extraction process. A deeper understanding of the relationship between material variability and biological activity and the definition of standardized manufacturing procedures will be crucial for the future of natural materials in tissue engineering.

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Authors and Affiliations

  1. BIOtech Research Center and Department of Industrial Engineering, European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Trento, Trento, Italy

    Walter Bonani & Antonella Motta

  2. Department of Orthopedic Surgery, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand

    Weerasak Singhatanadgige

  3. Bioactive Resources for Innovative Clinical Applications Research Unit and Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand

    Aramwit Pornanong

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  1. Walter Bonani
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  2. Weerasak Singhatanadgige
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  3. Aramwit Pornanong
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  4. Antonella Motta
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  1. 3B’s Research Group – Biomaterials, Biodegradables and Biomimetics University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Barco, Guimarães, Portugal

    J. Miguel Oliveira

  2. 3B’s Research Group – Biomaterials, Biodegradables and Biomimetics University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Barco, Guimarães, Portugal

    Sandra Pina

  3. 3B’s Research Group – Biomaterials, Biodegradables and Biomimetics University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Barco, Guimarães, Portugal

    Rui L. Reis

  4. Polymeric Nanomaterials and Biomaterials Department, Institute of Polymer Science and Technology, Spanish Council for Scientific Research (CSIC), Madrid, Spain

    Julio San Roman

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Bonani, W., Singhatanadgige, W., Pornanong, A., Motta, A. (2018). Natural Origin Materials for Osteochondral Tissue Engineering. In: Oliveira, J., Pina, S., Reis, R., San Roman, J. (eds) Osteochondral Tissue Engineering. Advances in Experimental Medicine and Biology, vol 1058. Springer, Cham. https://doi.org/10.1007/978-3-319-76711-6_1

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