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Biomaterials in Meniscus Tissue Engineering

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Regenerative Strategies for the Treatment of Knee Joint Disabilities

Part of the book series: Studies in Mechanobiology, Tissue Engineering and Biomaterials ((SMTEB,volume 21))

Abstract

Meniscus is a complex tissue that plays important roles on the knee performance and homeostasis. The meniscus tissue is very susceptible to injury and despite the great advances in meniscus regeneration area, none of the current strategies for the treatment of meniscus lesions are completely effective. To overcome such great challenge, tissue engineering-based strategies have been attempted. One of the main targets in this research area is to find out a biomaterial or formulations that are able to mimic as much as possible the meniscus native extracellular matrix. In the last few years the characteristics and behaviors of different biomaterials were explored and several processing routes attempted to obtain an adequate architecture for proper cells adhesion, ingrowths, proliferation and differentiation. Herein, a panoply of biomaterials that have been used in meniscus tissue engineering strategies are overviewed.

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Acknowledgments

Authors acknowledge the financial support from FCT/MCTES (Fundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia, e Ensino Superior) and the Fundo Social Europeu através do Programa Operacional do Capital Humano (FSE/POCH), PD/59/2013. J.M. Oliveira also thanks to the Portuguese Foundation for Science and Technology (FCT) for the funds provided to under the program Investigador FCT 2012 (IF/00423/2012)

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  1. 3B’s Research Group—Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, AvePark, Zona Industrial Da Gandra, 4805-017, Barco GMR, Portugal

    João B. Costa, Joaquim Miguel Oliveira & Rui Luís Reis

  2. ICVS/3B’s—PT Government Associate Laboratory, Braga, Guimarães, Portugal

    João B. Costa, Joaquim Miguel Oliveira & Rui Luís Reis

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  1. 3B’s Research Group—Biomaterials, Biodegradables and Biomimetics, University of Minho, Guimarães, Portugal

    Joaquim Miguel Oliveira

  2. ICVS/3B’s—PT Government Associate, Laboratory, University of Minho, Guimarães, Portugal

    Rui Luís Reis

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Costa, J.B., Oliveira, J.M., Reis, R.L. (2017). Biomaterials in Meniscus Tissue Engineering. In: Oliveira, J., Reis, R. (eds) Regenerative Strategies for the Treatment of Knee Joint Disabilities. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 21. Springer, Cham. https://doi.org/10.1007/978-3-319-44785-8_13

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