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Mechanistic Modeling of Inflammation

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Systems Pharmacology and Pharmacodynamics

Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series ((AAPS,volume 23))

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Abstract

In this chapter we explore the characteristics underlying the development of mechanistic-based models of inflammation. The discussion covers the three basic arms of developing mechanistic models. We begin by exploring the likely experimental analogues producing critical information, we then review modeling alternatives for representing the biological system under study, and finally we review the key methods for executing the model and performing the required calculation. The discussion concludes with a brief overview of the challenges and opportunities in the context of bridging the gap between (mechanistic) disease and pharmacology models as we move towards more integrated systems pharmacology approaches with the ultimate goal of designing relevant in silico clinical trials enabling rational extrapolation of bench observations.

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Acknowledgments

The authors acknowledge financial support from NIH GM082974.

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Authors and Affiliations

  1. Biomedical Engineering Department, Rutgers University, New Brunswick, NJ, USA

    Jeremy D. Scheff & Ioannis P. Androulakis

  2. Chemical and Biochemical Engineering Department, Rutgers University, New Brunswick, NJ, USA

    Kubra Kamisoglu & Ioannis P. Androulakis

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  1. Jeremy D. Scheff
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  2. Kubra Kamisoglu
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  3. Ioannis P. Androulakis
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Correspondence to Ioannis P. Androulakis .

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  1. Department of Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, New York, USA

    Donald E. Mager

  2. Global Clinical Pharmacology, Janssen Research and Development, LLC,, Spring House, Pennsylvania, USA

    Holly H.C. Kimko

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Scheff, J.D., Kamisoglu, K., Androulakis, I.P. (2016). Mechanistic Modeling of Inflammation. In: Mager, D., Kimko, H. (eds) Systems Pharmacology and Pharmacodynamics. AAPS Advances in the Pharmaceutical Sciences Series, vol 23. Springer, Cham. https://doi.org/10.1007/978-3-319-44534-2_15

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