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AMPK in Cardiovascular Diseases

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AMP-activated Protein Kinase

Part of the book series: Experientia Supplementum ((EXS,volume 107))

Abstract

This chapter summarizes the implication of AMP-activated protein kinase (AMPK) in the regulation of various physiological and pathological cellular events of great importance for the maintenance of cardiac function. These include the control of both metabolic and non-metabolic elements targeting the different cellular components of the cardiac tissue, i.e., cardiomyocytes, fibroblasts, and vascular cells. The description of the multifaceted action of the two AMPK catalytic isoforms, α1 and α2, emphasizes the general protective action of this protein kinase against the development of critical pathologies like myocardial ischemia, cardiac hypertrophy, diabetic cardiomyopathy, and heart failure.

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Authors and Affiliations

  1. Université catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Pole of Cardiovascular Research, Brussels, Belgium

    Evangelos P. Daskalopoulos, Cécile Dufeys, Christophe Beauloye, Luc Bertrand & Sandrine Horman

  2. Cardiovascular Research (Care) Institute, Athens, Ioannina, Greece

    Evangelos P. Daskalopoulos

  3. Division of Cardiology, Cliniques universitaires Saint-Luc, Brussels, Belgium

    Christophe Beauloye

Authors
  1. Evangelos P. Daskalopoulos
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  2. Cécile Dufeys
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  3. Christophe Beauloye
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  4. Luc Bertrand
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  5. Sandrine Horman
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Correspondence to Luc Bertrand .

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Editors and Affiliations

  1. Oral Medicine Department, Universidad de Sevilla, Sevilla, Spain

    Mario D. Cordero

  2. INSERM U1016 Institut Cochin CNRS UMR 8104, Université Paris Descartes, Paris, France

    Benoit Viollet

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Daskalopoulos, E.P., Dufeys, C., Beauloye, C., Bertrand, L., Horman, S. (2016). AMPK in Cardiovascular Diseases. In: Cordero, M., Viollet, B. (eds) AMP-activated Protein Kinase. Experientia Supplementum, vol 107. Springer, Cham. https://doi.org/10.1007/978-3-319-43589-3_8

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