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The Role of Glucose and Lipid Metabolism in Growth and Survival of Cancer Cells

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Metabolism in Cancer

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 207))

Abstract

One of the prerequisites for cell growth and proliferation is the synthesis of macromolecules, including proteins, nucleic acids and lipids. Cells have to alter their metabolism to allow the production of metabolic intermediates that are the precursors for biomass production. It is now evident that oncogenic signalling pathways target metabolic processes on several levels and metabolic reprogramming has emerged as a hallmark of cancer. The increased metabolic demand of cancer cells also produces selective dependencies that could be targeted for therapeutic intervention. Understanding the role of glucose and lipid metabolism in supporting cancer cell growth and survival is crucial to identify essential processes that could provide therapeutic windows for cancer therapy.

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Authors and Affiliations

  1. Biocenter, Theodor-Boveri-Institute, Am Hubland, 97074, Würzburg, Germany

    Charlene Brault & Almut Schulze

  2. Comprehensive Cancer Center Mainfranken, Josef-Schneider-Str. 6, 97080, Würzburg, Germany

    Almut Schulze

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  1. Charlene Brault
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  1. RWTH University Hospital, Molecular Tumor Biology, Pauwelsstrasse 30, 52074 , Aachen, Germany

    Thorsten Cramer

  2. Dept. of Hematology and Oncology, Charité, Berlin, Germany

    Clemens A. Schmitt

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Brault, C., Schulze, A. (2016). The Role of Glucose and Lipid Metabolism in Growth and Survival of Cancer Cells. In: Cramer, T., A. Schmitt, C. (eds) Metabolism in Cancer. Recent Results in Cancer Research, vol 207. Springer, Cham. https://doi.org/10.1007/978-3-319-42118-6_1

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