Metabolism in Cancer

  • Thorsten Cramer
  • Clemens  A. Schmitt

Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 207)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Stefan Walenta, Nadine F. Voelxen, Wolfgang Mueller-Klieser
    Pages 23-37
  3. Evan C. Lien, Costas A. Lyssiotis, Lewis C. Cantley
    Pages 39-72
  4. Annie L. Hsieh, Chi V. Dang
    Pages 73-91
  5. Alan McIntyre, Adrian L. Harris
    Pages 93-134
  6. Andrea Viale, Giulio F. Draetta
    Pages 135-156
  7. Jan Budczies, Carsten Denkert
    Pages 157-175
  8. Ivayla Apostolova, Florian Wedel, Winfried Brenner
    Pages 177-205
  9. Christin Zasada, Stefan Kempa
    Pages 207-220
  10. Nikolaus Berndt, Hermann-Georg Holzhütter
    Pages 221-232
  11. Christopher Smyl
    Pages 233-240
  12. Sebastian Brandhorst, Valter D. Longo
    Pages 241-266

About this book

Introduction

This textbook presents concise chapters written by internationally respected experts on various important aspects of cancer-associated metabolism, offering a comprehensive overview of the central features of this exciting research field. The discovery that tumor cells display characteristic alterations of metabolic pathways has significantly changed our understanding of cancer: while the first description of tumor-specific changes in cellular energetics was published more than 90 years ago, the causal significance of this observation for the pathogenesis of cancer was only discovered in the post-genome era. The first 10 years of the twenty-first century were characterized by rapid advances in our grasp of the functional role of cancer-specific metabolism as well as the underlying molecular pathways. Various unanticipated interrelations between metabolic alterations and cancer-driving pathways were identified and currently await translation into diagnostic and therapeutic applications. Yet the speed, quantity, and complexity of these new discoveries make it difficult for researchers to keep up to date with the latest developments, an issue this book helps to remedy.

Keywords

Cancer-specific metabolism Glycolysis Mitochondria Oncogenes Lactate

Editors and affiliations

  • Thorsten Cramer
    • 1
  • Clemens  A. Schmitt
    • 2
  1. 1.RWTH University Hospital, Molecular Tumor Biology, Pauwelsstrasse 30, 52074 AachenGermany
  2. 2.Dept. of Hematology and OncologyCharitéBerlinGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-42118-6
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-42116-2
  • Online ISBN 978-3-319-42118-6
  • Series Print ISSN 0080-0015
  • Series Online ISSN 2197-6767
  • About this book