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Lead Exposure and Oxidative Stress: A Systematic Review

  • Chapter
Reviews of Environmental Contamination and Toxicology Volume 236

Part of the book series: Reviews of Environmental Contamination and Toxicology ((RECT,volume 236))

Abstract

Lead is an environmental toxicant that can induce oxidative stress (OS) via reactive oxygen species (ROS) generation, which has been reported as an important mechanism underlying lead toxicity (Gurer and Ercal 2000; Pande and Flora 2002; Kasperczyk et al. 2004a; Farmand et al. 2005; Verstraeten et al. 2008; Wang et al. 2009; Martinez-Haro et al. 2011). OS occurs when the generation of ROS exceeds the antioxidant system’s ability to defend cells against oxidized molecules. ROS is a term generally used to refer to free radicals derived from O2 (e.g., superoxide anions [O2 −] and hydroxyl radicals [OH−]) or to non-radical species (e.g. hydrogen peroxide [H2O2]) (Halliwell and Cross 1994).

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Acknowledgements and Funding Sources

This research has been supported by the Coordination for the Improvement of Higher Level -or Education- Personnel (CAPES) through the Ministry of Health, Brazil.

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Authors and Affiliations

  1. Graduate Program in Public Health, State University of Londrina, 60 Robert Koch Avenue, Parana, Brazil

    Ana Carolina B. Almeida Lopes

  2. Department of Pathology, Clinical and Toxicological Analysis, Health Science Center, State University of Londrina, 60 Robert Koch Avenue, Parana, Brazil

    Tiago S. Peixe

  3. Graduate Program in Public Health, Department of Public Health, Health Science Center, State University of Londrina, 60 Robert Koch Avenue, Parana, Brazil

    Arthur E. Mesas

  4. Graduate Program in Public Health, Department of Pathology, Clinical and Toxicological Analysis, Health Science Center, State University of Londrina, 60 Robert Koch Avenue, Parana, Brazil

    Monica M. B. Paoliello

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Appendix 1: Search Strategy

Appendix 1: Search Strategy

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((((((((lead[Title/Abstract])) AND (((blood[Title/Abstract])) OR (ALAU[Title/Abstract])))) AND (((((poison*[Title/Abstract]) OR expos*[Title/Abstract]) OR occupation*[Title/Abstract]) OR contamination[Title/Abstract]) OR environmental[Title/Abstract]))) AND (((oxidative[Title/Abstract])) AND (((stress[Title/Abstract]) OR damage[Title/Abstract]) OR injury[Title/Abstract])))) OR (((((((lead[Title/Abstract])) AND (((blood[Title/Abstract])) OR (ALAU[Title/Abstract])))) AND (((((poison*[Title/Abstract]) OR expos*[Title/Abstract]) OR occupation*[Title/Abstract]) OR contamination[Title/Abstract]) OR environmental[Title/Abstract]))) AND (((((((((((((ALAD[Title/Abstract]) OR MDA[Title/Abstract]) OR SOD[Title/Abstract]) OR CAT[Title/Abstract]) OR 4HNE[Title/Abstract]) OR GPx[Title/Abstract]) OR G6PD[Title/Abstract]) OR GSSG[Title/Abstract]) OR GSH[Title/Abstract]) OR GR[Title/Abstract]) OR ZPP[Title/Abstract]) OR NADP[Title/Abstract]) OR NADPH[Title/Abstract]))

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lead AND blood AND oxidative stress

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lead AND blood AND oxidative stress

Databases: PubMed (http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed); Web of Knowledge (http://apps.webofknowledge.com.ez78.periodicos.capes.gov.br/WOS_GeneralSearch_input.do?product =WOS&search_mode = GeneralSearch&SID = 3BpD4JEBm5kK9iK3Lm3&preferencesSaved=); TOXLINE (http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?TOXLINE).

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Lopes, A.C.B.A., Peixe, T.S., Mesas, A.E., Paoliello, M.M.B. (2016). Lead Exposure and Oxidative Stress: A Systematic Review. In: de Voogt, P. (eds) Reviews of Environmental Contamination and Toxicology Volume 236. Reviews of Environmental Contamination and Toxicology, vol 236. Springer, Cham. https://doi.org/10.1007/978-3-319-20013-2_3

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