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Abstract

Environmental and occupational exposure to a large number of chemicals occurs at various stages throughout human life. Many of these are devoid of toxicity, but some could pose a significant health risk, i.e. the exposure to environmental xenobiotic metals as lead, mercury (Sinicropi et al. 2010a; Carocci et al. 2014), cadmium, etc. In particular, lead has long been a widespread public concern (Basha and Reddy 2010). Lead is one of the earliest heavy metals discovered by men. Due to its unique properties, as low melting point, softness, malleability, ductility, and resistance to corrosion, men have used lead for the last 5000 years in a wide range of applications.

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References

  • Adonaylo VN, Oteiza PI (1999) Pb2+ promotes lipid peroxidation and alteration in membrane physical properties. Toxicology 132:19–32

    CAS  Google Scholar 

  • Agarwal R, Goel SK, Behari JR (2010) Detoxification and antioxidant effects of curcumin in rats experimentally exposed to mercury. J Appl Toxicol 30:457–468

    CAS  Google Scholar 

  • Ahamed M, Siddiqui MK (2007) Environmental lead toxicity and nutritional factors. Clin Nutr 26:400–408

    CAS  Google Scholar 

  • Ahamed M, Verma S, Kumar A, Siddiqui MK (2005) Environmental exposure to lead and its correlation with biochemical indices in children. Sci Total Environ 346:48–55

    CAS  Google Scholar 

  • Ajumobi OO, Tsofo A, Yango M, Aworrh MK, Anagbogu IN, Mohammed A, Umar-Tsafe N, Mohammed S, Abdllahi M, Davis L, Idris S, Poggensee G, Nguku P, Gitta S, Nsubuga P (2014) High concentration of blood lead levels among young children in Bagega community, Zamfara - Nigeria and the potential risk factor. Pan Afr Med J 18(Suppl 1):14

    Google Scholar 

  • Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB (2007) Bioavailability of curcumin: problems and promises. Mol Pharm 4:807–818

    CAS  Google Scholar 

  • Annibaldi A, Truzzi C, Illuminati S, Scarponi G (2009) Recent sudden decrease of lead in Adriatic coastal seawater during the years 2000–2004 in parallel with the phasing out of leaded gasoline in Italy. Mar Chem 113:238–249

    CAS  Google Scholar 

  • Arvig E, Grandjean P, Beckmann J (1980) Neurotoxic effects of heavy lead exposure determined with psychological tests. Toxicol Lett 5:399–404

    Google Scholar 

  • Baghurst PA, McMichael AJ, Wigg NR, Vimpani GV, Robertson EF, Roberts RJ, Tong SL (1992) Environmental exposure to lead and children’s intelligence at the age of seven years. The Port Pirie Cohort Study. N Engl J Med 327:1279–1284

    CAS  Google Scholar 

  • Baker EL (1982) Neurologic and behavioral disorders. In: Levy BS, Wegman DH (eds) Occupational health: recognition and prevention of work-related disease. Little, Brown and Co, Boston, MA

    Google Scholar 

  • Baker EL, Feldman RG, White RA, Harley JP, Niles CA, Dinse GE, Berkey CS (1984) Occupational lead neurotoxicity: a behavioural and electrophysiological evaluation. Study design and year one results. Br J Ind Med 41:352–361

    CAS  Google Scholar 

  • Basha R, Reddy GR (2010) Developmental exposure to lead and late life abnormalities of nervous system. Indian J Exp Biol 48:636–641

    CAS  Google Scholar 

  • Beattie AD, Moore MR, Goldberg A (1972) Tetraethyl-lead poisoning. Lancet 300:12–15

    Google Scholar 

  • Bechara EJ (1996) Oxidative stress in acute intermittent porphyria and lead poisoning may be triggered by 5-aminolevulinic acid. Braz J Med Biol Res 29:841–851

    CAS  Google Scholar 

  • Begovic V, Nozic D, Kupresanin S, Tarabar D (2008) Extreme gastric dilation caused by chronic lead poisoning: a case report. World J Gastroenterol 14:2599–2601

    Google Scholar 

  • Bellinger DC (2004) Lead. Pediatrics 113:1016–1022

    Google Scholar 

  • Bellinger DC (2005) Teratogen update: lead and pregnancy. Birth Def Res A Clin Mol Teratol 73:409–420

    CAS  Google Scholar 

  • Berndtsson R (1993) Small-scale spatial patterns of bulk atmospheric deposition. J Environ Qual 22:349–360

    CAS  Google Scholar 

  • Brent JA (2006) Review of: “Medical Toxicology”. Clin Toxicol 44:355

    Google Scholar 

  • Bressler J, Kim KA, Chakraborti T, Goldstein G (1999) Molecular mechanisms of lead neurotoxicity. Neurochem Res 24:595–600

    CAS  Google Scholar 

  • Brodkin E, Copes R, Mattman A, Kennedy J, Kling R, Yassi A (2007) Lead and mercury exposures: interpretation and action. Can Med Assoc J 17:59–63

    Google Scholar 

  • Carocci A, Rovito N, Sinicropi MS, Genchi G (2014) Mercury toxicity and neurodegenerative effects. Rev Environ Contam Toxicol 229:1–18

    CAS  Google Scholar 

  • Chaurasia SS, Kar A (1997) Protective effects of vitamin E against lead-induced deterioration of membrane associated type-1 iodothyronine 5′-monodeiodinase (5′D-I) activity in male mice. Toxicology 124:203–209

    CAS  Google Scholar 

  • Cleveland LM, Minter ML, Cobb KA, Scott AA, German VF (2008) Lead hazards for pregnant women and children: Part 1: immigrants and the poor shoulder most of the burden of lead exposure in this country. Part 1 of a two-part article details how exposure happens, whom it affects, and the harm it can do. Am J Nurs 108:40–49

    Google Scholar 

  • Cory-Slechta DA (1996) Legacy of lead exposure: consequences for the central nervous system. Otolaryngol Head Neck Surg 114:224–226

    CAS  Google Scholar 

  • Daniel S, Limson JL, Dairam A, Watkins GM, Daya S (2004) Through metal binding, curcumin protects against lead- and cadmium-induced lipid peroxidation in rat brain homogenates and against lead-induced tissue damage in rat brain. J Inorg Biochem 98:266–275

    CAS  Google Scholar 

  • Dart RC, Hurlbut KM, Boyer-Hassen LV (2004) Lead. In: Dart RC (ed) Medical toxicology, 3rd edn. Lippincott Williams & Wilkins, Philadelphia, PA, pp 1423–1431

    Google Scholar 

  • DeJonghe WRA, Adams FC (1986) Biogeochemical cycling of organic lead compounds. Adv Environ Sci Technol 17:561–594

    CAS  Google Scholar 

  • Dietert RR, Piepenbrink MS (2006) Lead and immune function. Crit Rev Toxicol 36:359–385

    CAS  Google Scholar 

  • Dooyema CA, Neri A, Lo YC, Durant J, Dargan PI, Swarthout T, Biya O, Gidado SO, Haladu S, Sani-Gwarzo N, Nguku PM, Akpan H, Idris S, Bashir AM, Brown MJ (2012) Outbreak of fatal childhood lead poisoning related to artisanal gold mining in northwestern Nigeria, 2010. Environ Health Perspect 120:601–607

    CAS  Google Scholar 

  • Eisler R (1988) Lead hazards to fish, wildlife, and invertebrates: a synoptic review, vol 85 (1.14), Biol report. U.S. Department of the Interior, Fish and Wildlife Service, Laurel, MD

    Google Scholar 

  • EPA (1986) Air quality criteria for lead. U.S. Environmental Protection Agency, Office of Research and Development, Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Research Triangle Park, NC, EPA600883028F

    Google Scholar 

  • Ercal N, Gurer-Orhan H, Aykin-Burns N (2001) Toxic metals and oxidative stress. Part 1. Mechanisms involved in metal-induced oxidative damage. Curr Top Med Chem 1:529–539

    CAS  Google Scholar 

  • Feldman RG, Ricks NL, Baker EL (1980) Neurophysiological effects of industrial toxins: a review. Am J Ind Med 1:211–227

    CAS  Google Scholar 

  • Flora SJS (2002) Nutritional components modify metal absorption, toxic response and chelation therapy. J Nutr Environ Med 12:53–67

    CAS  Google Scholar 

  • Flora SJS (2009) Structural, chemical and biological aspects of antioxidants for strategies against metal and metalloid exposure. Oxid Med Cell Longev 2:191–206

    Google Scholar 

  • Flora SJ, Pande M, Mehta A (2003) Beneficial effect of combined administration of some naturally occurring antioxidants (vitamins) and thiol chelators in the treatment of chronic lead intoxication. Chem Biol Interact 145:267–280

    CAS  Google Scholar 

  • Flora SJS, Flora GJS, Saxena G (2006) Environmental occurrence, health effects and management of lead poisoning. In: Cascas SB, Sordo J (eds) Lead: chemistry, analytical aspects, environmental impacts and health effects. Elsevier Publication, Netherlands, pp 158–228

    Google Scholar 

  • Flora SJ, Flora G, Saxena G, Mishra M (2007) Arsenic and lead induced free radical generation and their reversibility following chelation. Cell Mol Biol (Noisy-le-Grand) 53:26–47

    CAS  Google Scholar 

  • Flora SJS, Pachauri V, Saxena G (2011) Arsenic, cadmium and lead. In: Gupta RC (ed) Reproductive and developmental toxicology, vol 33. Academic, New York, NY, pp 415–438

    Google Scholar 

  • Flora G, Gupta D, Tiwari A (2012) Toxicity of lead: a review with recent updates. Interdiscip Toxicol 5:47–58

    CAS  Google Scholar 

  • Gandhi P, Khan Z, Chakraverty N (2011) Soluble curcumin: a promising oral supplement for health management. J Appl Pharm Sci 1:01–07

    Google Scholar 

  • Garcia MTA, Gonzalez ELM (2008) Toxic effects of perinatal lead exposure on the brain of rats: involvement of oxidative stress and the beneficial role of antioxidants. Food Chem Toxicol 46:2089–2095

    Google Scholar 

  • Garza A, Vega R, Soto E (2006) Cellular mechanisms of lead neurotoxicity. Med Sci Monit 12:RA57–RA65

    Google Scholar 

  • Goldstein GW (1990) Lead poisoning and brain cell function. Environ Health Perspect 89:91–94

    CAS  Google Scholar 

  • Gonick HC (2002) Lead, renal disease and hypertension. Am J Kidney Dis 40:202–204

    Google Scholar 

  • Goyer R (1993) Lead toxicity: current concerns. Environ Health Perspect 100:177–187

    CAS  Google Scholar 

  • Grant LD, Davis JM (1989) Effects of low-level lead exposure on paediatric neurobehavioural development: current findings and future directions. In: Smith MA, Grant LD, Sors AI (eds) Lead exposure and child development: an international assessment. MTP Press, Lancaster, pp 49–118

    Google Scholar 

  • Gulson BL (2000) Revision of estimates of skeletal contribution to blood during pregnancy and postpartum period. J Lab Clin Med 136:250–251

    CAS  Google Scholar 

  • Gupta RC (2012) Veterinary toxicology: basic and clinical principles, 2nd edn. Elsevier, London

    Google Scholar 

  • Heim KE, Tagliaferro AR, Bobliya DJ (2002) Flavonoid antioxidants: chemistry, metabolism and structure activity relationships. J Nutr Biochem 13:572–584

    CAS  Google Scholar 

  • Holmgren GGS, Meyer MW, Chaney RL, Daniels RB (1993) Cadmium, lead, cooper, and nickel in agricultural soils of the United States of America. J Environ Qual 22:335–348

    CAS  Google Scholar 

  • Hu H, Rabinowitz M, Smith D (1998) Bone lead as a biological marker in epidemiologic studies of chronic toxicity: conceptual paradigms. Environ Health Perspect 106:1–8

    CAS  Google Scholar 

  • Hu H, Shih R, Rothenberg S, Schwartz BS (2007) The epidemiology of lead toxicity in adults: measuring dose and consideration of other methodologic issues. Environ Health Perspect 115:455–462

    CAS  Google Scholar 

  • Hunaiti A, Soud M, Khalil A (1995) Lead concentration and the level of glutathione, glutathione S-transferase, reductase and peroxidase in the blood of some occupational workers from Irbid City, Jordan. Sci Total Environ 170:95–100

    CAS  Google Scholar 

  • Ibrahim NM, Eweis EA, El-Beltagi HS, Abdel-Mobdy YE (2012) Effect of lead acetate toxicity on experimental male albino rat. Asian Pac J Trop Biomed 2:41–46

    CAS  Google Scholar 

  • International Agency for Research on Cancer (2006) Inorganic and organic lead compounds, vol 87, IARC monographs on the evaluation of carcinogenic risks to humans. International Agency for Research on Cancer (IARC), Lyon

    Google Scholar 

  • IPCS (International Programme on Chemical Safety) (1995) Inorganic lead. Environmental health criteria 165. WHO, Geneva

    Google Scholar 

  • Jangid AP, John PJ, Yadav D, Mishra S, Sharma P (2012) Impact of chronic lead exposure on selected biological markers. Indian J Clin Biochem 27:83–89

    CAS  Google Scholar 

  • Kasperczyk S, Kasperczyk A, Ostalowska A, Dziwisz M, Birkner E (2004) Activity of glutathione peroxidase, glutathione reductase, and lipid peroxidation in erythrocytes in workers exposed to lead. Biol Trace Elem Res 102:61–72

    CAS  Google Scholar 

  • Levander OA, Morris VC, Ferretti RJ (1977) Filterability of erythrocytes from vitamin E-deficient lead poisoned rats. J Nutr 107:363–372

    CAS  Google Scholar 

  • Lidsky TI, Schneider JS (2003) Lead neurotoxicity in children: basic mechanisms and clinical correlates. Brain 126:5–19

    Google Scholar 

  • Liu CM, Zheng YL, Lu J, Zhang ZF, Fan SH, Wu DM, Ma JQ (2010a) Quercetin protects rat liver against lead-induced oxidative stress and apoptosis. Environ Toxicol Pharmacol 29:158–166

    CAS  Google Scholar 

  • Liu CM, Ma JQ, Sun YZ (2010b) Quercetin protects the rat kidney against oxidative stress-mediated DNA damage and apoptosis induced by lead. Environ Toxicol Pharmacol 30:264–271

    CAS  Google Scholar 

  • Liu CM, Sun YZ, Sun JM, Ma JQ, Cheng C (2012) Protective role of quercetin against lead-induced inflammatory response in rat kidney through the ROS-mediated MAPKs and NF-κB pathway. Biochim Biophys Acta 1820:1693–1703

    CAS  Google Scholar 

  • Liu CM, Zheng GH, Ming QL, Sun JM, Cheng C (2013) Protective effect of quercetin on lead-induced oxidative stress and endoplasmic reticulum stress in rat liver via the IRE1/JNK and PI3K/Akt pathway. Free Radic Res 47:192–201

    CAS  Google Scholar 

  • Macintyre JE (1994) Dictionary of organometallic compounds. CRC Press, Boca Raton, FL. ISBN ISBN 9780412430602

    Google Scholar 

  • Mates JM (2000) Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology. Toxicology 153:83–104

    CAS  Google Scholar 

  • McGowan C (1989) Influence of vitamin B6 status on aspects of lead poisoning in rats. Toxicol Lett 47:87–93

    CAS  Google Scholar 

  • McGrath SP, Chang AC, Page AL, Witter E (1994) Land application of sewage sludge: scientific perspectives of heavy metal loading limits in Europe and the United States. Environ Rev 2:108–118

    CAS  Google Scholar 

  • Monteiro HP, Abdalla DSP, Faljoni-Alario A, Bechara EJH (1986) Generation of active oxygen species during coupled autoxidation of oxyhemoglobin and delta-aminolevulinic acid. Biochim Biophys Acta 881:100–106

    CAS  Google Scholar 

  • Mozafari MR, Flanagan J, Matia-Merino L, Awati A, Omri A, Suntres Z, Singh H (2006) Recent trends in the lipid-based nanoencapsulation of antioxidants and their role in foods. J Sci Food Agric 86:2038–2045

    CAS  Google Scholar 

  • Mozafari MR, Johnson C, Hatziantoniou S, Demetzos C (2008) Nanoliposomes and their applications in food nanotechnology. J Liposome Res 18:309–327

    Google Scholar 

  • Needleman H (2004) Lead poisoning. Annu Rev Med 55:209–222

    CAS  Google Scholar 

  • Nielsen T (1984) Atmospheric occurrence of organolead compounds. In: Grandjean P (ed) Biological effects of organolead compounds. CRC Press, Boca Raton, FL, pp 43–62

    Google Scholar 

  • Patrick L (2006) Lead toxicity, a review of the literature. Part 1: Exposure, evaluation, and treatment. Altern Med Rev 11:2–22

    Google Scholar 

  • Patterson C (1956) Age of meteorites and the earth. Geochim Cosmochim Acta 10:230–237

    CAS  Google Scholar 

  • Pearce JM (2007) Burton’s line in lead poisoning. Eur Neurol 57:118–119

    CAS  Google Scholar 

  • Philip AT, Gerson B (1994) Lead poisoning--Part I. Incidence, etiology, and toxicokinetics. Clin Lab Med 14:423–444

    CAS  Google Scholar 

  • Piomelli S (2002) Childhood lead poisoning. Pediatr Clin North Am 49:1285–1304

    Google Scholar 

  • Rastogi SK (2008) Renal effects of environmental and occupational lead exposure. Ind J Occup Environ Med 12:103–106

    CAS  Google Scholar 

  • Reddy KJ, Wang L, Gloss SP (1995) Solubility and mobility of copper, zinc and lead in acidic environments. Plant Soil 171:53–58

    CAS  Google Scholar 

  • Reed BE, Moore RE, Cline SR (1995) Soil flushing of a sandy loam contaminated with Pb(II), PbSO4 (s), PbCO3 (3) or Pb-naphthalene: column results. J Soil Contam 4:243–267

    CAS  Google Scholar 

  • Rendón-Ramirez A, Cerbón-Solórzano J, Maldonado-Vega M, Quintanar-Escorza MA, Calderón-Salinas JV (2007) Vitamin-E reduces the oxidative damage on delta-aminolevulinic dehydratase induced by lead intoxication in rat erythrocytes. Toxicol In Vitro 21:1121–1126

    Google Scholar 

  • Renner R (2010) Exposure on tap: drinking water as an overlooked source of lead. Environ Health Perspect 118:A68–A74

    Google Scholar 

  • Sajitha GR, Jose R, Andrews A, Ajantha KG, Augustine P, Augusti KT (2010) Garlic oil and vitamin E prevent the adverse effects of lead acetate and ethanol separately as well as in combination in the drinking water of rats. Indian J Clin Biochem 25:280–288

    CAS  Google Scholar 

  • Saleh HA, El-Aziz GA, El-Fark MM, El-Gohary M (2009) Effect of maternal lead exposure on craniofacial ossification in rat fetuses and the role of antioxidant therapy. Anat Histol Embryol 38:392–399

    CAS  Google Scholar 

  • Sanders T, Liu Y, Buchner V, Tchounwou PB (2009) Neurotoxic effects and biomarkers of lead exposure: a review. Res Environ Health 24:15–45

    CAS  Google Scholar 

  • Senapati SK, Dey S, Dwivedi SK, Patra RC, Swarup D (2000) Effect of thiamine hydrochloride on lead induced lipid peroxidation in rat liver and kidney. Vet Hum Toxicol 42:236–237

    CAS  Google Scholar 

  • Shalan MG, Mostafa MS, Hassouna MM, El-Nabi SE, El-Refaie A (2005) Amelioration of lead toxicity on rat liver with vitamin C and silymarin supplements. Toxicology 206:1–15

    CAS  Google Scholar 

  • Shan G, Tang T, Zhang X (2009) The protective effect of ascorbic acid and thiamine supplementation against damage caused by lead in the testes of mice. J Huazhong Univ Sci Technolog Med Sci 29:68–72

    CAS  Google Scholar 

  • Shukla PK, Khanna VK, Khan MY, Srimal RC (2003) Protective effect of curcumin against lead neurotoxicity in rat. Hum Exp Toxicol 22:653–658

    CAS  Google Scholar 

  • Silbergeld EK (1991) Lead in bone: implications for toxicology during pregnancy and lactation. Envirom Health Perspect 91:63–70

    CAS  Google Scholar 

  • Silbergeld EK (2003) Facilitative mechanisms of lead as a carcinogen. Mutat Res 533:121–133

    CAS  Google Scholar 

  • Silbergeld EK, Schwart J, Mahaffey K (1988) Lead and osteoporosis: mobilization of lead from bone in postmenopausal women. Environ Res 47:79–94

    CAS  Google Scholar 

  • Silbergeld EK, Sauk J, Somerman M, Todd A, McNeill F, Fowler B, Fontaine A, van Buren J (1993) Lead in bone: storage site, exposure source, and target organ. Neurotoxicology 14:225–236

    CAS  Google Scholar 

  • Silbergeld EK, Waalkes M, Rice JM (2000) Lead as a carcinogen: experimental evidence and mechanisms of action. Am J Ind Med 38:316–323

    CAS  Google Scholar 

  • Singh P, Sankhla V (2010) In situ protective effect of curcumin on cadmium chloride induced genotoxicity in bone marrow chromosomes of Swiss albino mice. J Cell Mol Biol 8:57–64

    CAS  Google Scholar 

  • Sinicropi MS, Amantea D, Caruso A, Saturnino C (2010a) Chemical and biological properties of toxic metals and use of chelating agents for the pharmacological treatment of metal poisoning. Arch Toxicol 84:501–520

    CAS  Google Scholar 

  • Sinicropi MS, Caruso A, Capasso A, Palladino C, Panno A, Saturnino C (2010b) Heavy metals: toxicity and carcinogenicity. Pharmacology 2:329–333

    Google Scholar 

  • Somervaille LJ, Chettle DR, Scott MC, Tennant DR, McKiernan MJ, Skilbeck A, Trethowan WN (1988) In vivo tibia lead measurements as an index of cumulative exposure in occupationally exposed subjects. Br J Ind Med 45:174–181

    CAS  Google Scholar 

  • Steenland K, Boffetta P (2000) Lead and cancer in humans: where are we now? Am J Ind Med 38:295–299

    CAS  Google Scholar 

  • Stollery BT, Banks HA, Broadbent DE, Lee WR (1989) Cognitive functioning in lead workers. Br J Ind Med 46:698–707

    CAS  Google Scholar 

  • Stollery BT, Broadbent DE, Banks HA, Lee WR (1991) Short term prospective cognitive functioning in lead workers. Br J Ind Med 48:739–749

    CAS  Google Scholar 

  • Tandon SK, Flora SJ, Singh S (1987) Influence of pyridoxine (vitamin B6) on lead intoxication in rats. Ind Health 25:93–96

    CAS  Google Scholar 

  • Tariq SA (2007) Role of ascorbic acid in scavenging free radicals and lead toxicity from biosystems. Mol Biotechnol 37:62–65

    CAS  Google Scholar 

  • Telisman S, Cvitkovic P, Gavella M, Pongracic J (1990) Semen quality in men with respect to blood lead and cadmium levels. In International symposium on Lead and cadmium toxicology. Peking, People’s Republic of China, pp 29–32

    Google Scholar 

  • Terao J (2009) Dietary flavonoids as antioxidants. Forum Nutr 61:87–94

    CAS  Google Scholar 

  • Tong S, McMichael AJ (1999) The magnitude, persistence and public health significance of cognitive effects of environmental lead exposure in childhood. J Environ Med 1:103–110

    Google Scholar 

  • Tulasi SJ, Reddy PUM, Rao JV (1992) Accumulation of lead and effects on total lipids and lipid derivatives in the freshwater fish Anabas testudineus (Bioch). Ecotoxicol Environ Saf 23:33–38

    CAS  Google Scholar 

  • van Wijngaarden E, Dosemeci M (2006) Brain cancer mortality and potential occupational exposure to lead: findings from the National Longitudinal Mortality Study, 1979–1989. Int J Cancer 119:1136–1144

    Google Scholar 

  • Vaziri ND (2002) Pathogenesis of lead-induced hypertension: role of oxidative stress. J Hypertens 20:S15–S20

    CAS  Google Scholar 

  • Vij AG (2009) Hemopoietic, hemostatic and mutagenic effects of lead and possible prevention by zinc and vitamin C. Al Ameen J Med Sci 2:27–36

    CAS  Google Scholar 

  • Wang C, Liang J, Zhang C, Bi Y, Shi X, Shi Q (2007) Effect of ascorbic acid and thiamine supplementation at different concentrations on lead toxicity in liver. Ann Occup Hyg 51:563–569

    CAS  Google Scholar 

  • Wolfe KL, Liu RH (2008) Structure–activity relationships of flavonoids in the cellular antioxidant activity assay. J Agric Food Chem 56:8404–8411

    CAS  Google Scholar 

  • Wu HM, Lin-Tan DT, Wang ML, Huang HY, Lee CL, Wang HS, Soong YK, Lin JL (2012) Lead level in seminal plasma may affect semen quality for men without occupational exposure to lead. Reprod Biol Endocrinol 10:91–95

    CAS  Google Scholar 

  • Youdim KA, Spencer JP, Schroeter H, Rice-Evans C (2002) Dietary flavonoids as potential neuroprotectants. Biol Chem 383:503–519

    CAS  Google Scholar 

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Acknowledgements

The authors gratefully acknowledge the financial support provided by Ministero dell’Istruzione, dell’Università e della Ricerca (MIUR, Italia).

Conflict of Interest The authors (AC, AC, GL, MSS, GG) declare no conflict of interest.

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Carocci, A., Catalano, A., Lauria, G., Sinicropi, M.S., Genchi, G. (2016). Lead Toxicity, Antioxidant Defense and Environment. In: de Voogt, P. (eds) Reviews of Environmental Contamination and Toxicology. Reviews of Environmental Contamination and Toxicology, vol 238. Springer, Cham. https://doi.org/10.1007/398_2015_5003

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