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Regulation of Instant Blood Mediated Inflammatory Reaction (IBMIR) in Pancreatic Islet Xeno-Transplantation: Points for Therapeutic Interventions

  • Conference paper
Immune Responses to Biosurfaces

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 865))

Abstract

Xeno-transplantation of pancreatic islets represents a promising therapeutic alternative for the treatment of type 1 diabetes mellitus. However, potent innate immune responses induced shortly after the transplantation of donor islets to the recipient, comprising the Instant Blood Mediated Immune Reaction (IBMIR), exert detrimental actions on islet graft function. The coagulation and complement cascades together with the leukocyte and platelet populations are the major players in IBMIR. This innate immune attack affects dramatically islet integrity and leads to significant loss of function of the xenograft. In the present review, we focus on the mechanisms contributing to IBMIR components and address therapeutic intervention approaches to limit IBMIR by administering inhibitors in circulation, by coating the islet surface with inhibitors or by generating transgenic donor animals; these approaches could result in improved xenograft survival.

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Acknowledgment

This work was supported in part by the European Community's Seventh Framework Programme under grant agreement n°602699 (DIREKT) and by the Deutsche Forschungsgemeinschaft (SFB-TRR 127 Project A3).

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Authors and Affiliations

  1. Department of Clinical Pathobiochemistry, Medical Faculty, Technische Universität Dresden, Fetscherstrasse 74, Dresden, 01307, Germany

    Ioannis Kourtzelis, Klara Kotlabova & Triantafyllos Chavakis

  2. Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, SE-751 85, Sweden

    Peetra U. Magnusson

  3. Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    John D. Lambris

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  1. Ioannis Kourtzelis
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  2. Peetra U. Magnusson
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  3. Klara Kotlabova
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  4. John D. Lambris
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  5. Triantafyllos Chavakis
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Correspondence to Ioannis Kourtzelis .

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Editors and Affiliations

  1. Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    John D. Lambris

  2. Immunology, Genetics and Pathology, University of Uppsala, Uppsala, Sweden

    Kristina N. Ekdahl

  3. Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Daniel Ricklin

  4. Immunology, Genetics and Pathology, University of Uppsala, Uppsala, Sweden

    Bo Nilsson

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Kourtzelis, I., Magnusson, P.U., Kotlabova, K., Lambris, J.D., Chavakis, T. (2015). Regulation of Instant Blood Mediated Inflammatory Reaction (IBMIR) in Pancreatic Islet Xeno-Transplantation: Points for Therapeutic Interventions. In: Lambris, J., Ekdahl, K., Ricklin, D., Nilsson, B. (eds) Immune Responses to Biosurfaces. Advances in Experimental Medicine and Biology, vol 865. Springer, Cham. https://doi.org/10.1007/978-3-319-18603-0_11

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