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Peptides and epithelial growth regulation

  • Chapter
Regulatory Peptides

Part of the book series: Experientia Supplementum ((EXS,volume 56))

Summary

There is now considerable evidence implicating several peptides in the control of gastrointestinal epithelial cell proliferation and cell renewal. While some of these may act directly, many may be involved in regulating the powerful trophic effects of the intake and digestion of food on the gut epithelium. — Several peptides have been associated with the regulation of intestinal cell proliferation. There is little doubt that gastrin is trophic to the stomach, but, its role in the rest of the gastrointestinal tract is debatable. Enteroglucagon has often been associated with increased intestinal epithelial proliferation, but at the moment all the evidence for this is circumstantial. The effects of peptide YY and bombesin warrant further study. The availability of recombinant epidermal growth factor (EGF) has recently enabled us to demonstrate a powerful trophic response to infused EGF throughout the gastrointestinal tract. The increasing availability of peptides will eventually allow the rigorous in vivo evaluation of the trophic role of these potentially very important peptides.

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  2. N. A. Wright
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  1. Royal Postgraduate Medical School Department of Histochemistry, Hammersmith Hospital, Du Cane Road, London, W12 0HS, England

    Julia M. Polak

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© 1989 Birkhäuser Verlag

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Goodlad, R.A., Wright, N.A. (1989). Peptides and epithelial growth regulation. In: Polak, J.M. (eds) Regulatory Peptides. Experientia Supplementum, vol 56. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9136-3_10

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  • DOI: https://doi.org/10.1007/978-3-0348-9136-3_10

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-7643-1976-2

  • Online ISBN: 978-3-0348-9136-3

  • eBook Packages: Springer Book Archive

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