Summary
The distribution and ontogeny of polypeptide YY (PYY)-and pancreatic polypeptide (PP)-immunoreactive cells in the gastrointestinal tract of rat were investigated. PYY-immunoreactive cells were numerous in the pylorus, ileum and colon and only a few cells were observed in the corpus, duodenum, jejunum and rectum. On the other hand, a few PP-immunoreactive cells were seen in the colon only. Both PYY-and PP-immunoreactive cells were of the open type, i.e., they extended from the basal lamina to the gut lumen. PYY-immunoreactive cells were observed first in the lower half of the stomach and in the intestine of 19 day-old embryo. The localization of the cells seemed to move along towards the pylorus and the lower part of the intestine. PP-immunoreactive cells could only be detected for the first time in the colon of 2 day-old rat. These cells appeared temporarily in the pylorus and rectum during the period 7 to 21 days after birth. It was concluded that the difference between PYY-and PP-immunoreactive cells in the distribution, frequency and ontogeny provide further evidence that PYY and PP occur in two independent cell types.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
El-Salhy M, Grimelius L (1983) Immunocytochemical demonstration of polypeptide YY (PYY) in the gastrointestinal tract of the monkey Macaca rhesus. Biomed Res (in press)
El-Salhy M, Grimelius L, Lundberg JM, Tatemoto K, Terenius L (1982a) Immunocytochemical evidence for the occurrence of PYY, a newly isolated gut polypeptide, in endocrine cells in the gut of amphibians and reptiles. Biomed Res 3:303–306
El-Salhy M, Wilander E, Grimelius L, Terenius L, Lundberg JM, Tatemoto K (1982b) The distribution of polypeptide YY (PYY)-and pancreatic polypeptide (PP)-immunoreactive cells in the domestic fowl. Histochemistry 75:25–30
El-Salhy M, Wilander E, Abu-Sinna G, Shabaka H, Lundberg JM, Tatemoto K (1982c) On the ontogeny of polypeptide YY (PYY) in the gut of chickens. Biomed Res 3:680–682
El-Salhy M, Grimelius L, Wilander E, Ryberg B, Terenius L, Lundberg JM, Tatemoto K (1983) Immunocytochemical identification of polypeptide YY (PYY) cells in the human gastrointestinal tract. Histochemistry 77:15–23
Lundberg JM, Tatemoto K, Terenius L, Helleström PM, Hökfelt T, Hamberger B (1982) Localization of peptide YY (PYY) in gastrointestinal endocrine cells and effects on intestinal blood flow and motility. Proc Natl Acad Sci USA 79:4471–4475
Sternberger LA (1979) Immunocytochemistry. 2nd ed. John Wiley and Sons, New York
Sundler F, Håkanson R, Larsson L-I (1977) Ontogeny of pancreatic polypeptide (PP) cells. Cell Tissue Res 178:303–306
Tatemoto K (1982) Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic exocrine secretion. Proc Natl Acad Sci USA 79:2514–2518
Tatemoto K, Mutt V (1980) Isolation of two novel candidate hormones using a chemical method for finding naturally occurring polypeptides. Nature 285:417–418
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
El-Salhy, M., Wilander, E., Juntti-Berggren, L. et al. The distribution and ontogeny of polypeptide YY (PYY)-and pancreatic polypeptide (PP)-immunoreactive cells in the gastrointestinal tract of rat. Histochemistry 78, 53–60 (1983). https://doi.org/10.1007/BF00491111
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00491111