Abstract
Until now 22 children with neuropsychiatric disorders have been imaged for brain dopamine and serotonin transporters using [123I] β-CIT. Imaging was carried out using dual head gamma camera equipped with fan beam collimators. The thalamic serotonin transporter density index 4 hours after injection was significantly lower (p<0.001) in depressive children with multifactorial courses (14 pts) compared to a group of non-depressive children (8 pts). Surprisingly no difference could be found in the middle brain, region known to have plenty of serotonin transporters. Based on Cipramil displacement and human autoradiographic studies, we are convinced that our abnormal findings in the thalamic area really reflect serotonin transporters.
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© 1999 Springer Basel AG
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Ahonen, A., Dahlström, M., Moilanen, I., Torniainen, P., Heikkilä, J. (1999). Brain Serotonin and Dopamine Transporters in Depressive Children. In: Bergmann, H., Köhn, H., Sinzinger, H. (eds) Radioactive Isotopes in Clinical Medicine and Research XXIII. Advances in Pharmacological Sciences. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8782-3_4
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DOI: https://doi.org/10.1007/978-3-0348-8782-3_4
Publisher Name: Birkhäuser, Basel
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