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Bone morphogenetic proteins in articular cartilage repair

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Bone Morphogenetic Proteins: Regeneration of Bone and Beyond

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Cartilage regeneration and repair is one of the major obstacles in current orthopedics. The importance is enormous since osteoarthritis (OA) is a major cause of disability among the adult population in the United States. OA is considered a process of attempted, but gradually failing, repair of damaged cartilage extracellular matrix, as the balance between synthesis and breakdown of matrix components is disturbed and shifted towards catabolism. In recent times, members of the bone morphogenetic proteins (BMP) family of proteins have received the highest attention among potential anabolic factors for cartilage repair because of their ability to induce matrix synthesis and promote repair in different connective tissues, including cartilage. This Chapter will review the information accumulated on BMPs from in vitro studies as well as from studies of repair in various animal models. The data show significant promise for BMPs in cartilage repair and suggest that this indication could become the most important application for BMPs in orthopedics.

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Author information

Authors and Affiliations

  1. Stryker, 35 South Street, Hopkinton, MA, 01748, USA

    David C. Rueger

  2. Department of Biochemistry and Section of Rheumatology, Rush University Medical Center, Chicago, IL, 60612, USA

    Susan Chubinskaya

Authors
  1. David C. Rueger
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  2. Susan Chubinskaya
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Editors and Affiliations

  1. Laboratory for Mineralized Tissues, School of Medicine, Salata 11, Zagreb, HR, 10000, Croatia

    Slobodan Vukicevic

  2. Genzyme Corporation, One Mountain Road, Framingham, MA, 01701-9322, USA

    Kuber T. Sampath

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Rueger, D.C., Chubinskaya, S. (2004). Bone morphogenetic proteins in articular cartilage repair. In: Vukicevic, S., Sampath, K.T. (eds) Bone Morphogenetic Proteins: Regeneration of Bone and Beyond. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7857-9_5

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  • DOI: https://doi.org/10.1007/978-3-0348-7857-9_5

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9598-9

  • Online ISBN: 978-3-0348-7857-9

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