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Assessing and counteracting the prooxidant effects of anticancer drugs

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Free Radicals and Aging

Part of the book series: EXS ((EXS,volume 62))

Summary

The relationship between peroxide generation and respective cellular damage, triggering various biochemical consequences is first discussed. Then we review the prooxidant effects of various anticancer drugs including anthracyclines and bleomycin, platinum derivatives and the N- and S-mustards. We present and discuss some experimental results on peroxidase inhibition by drugs such as zinc salts, almitrine, deferoxamine, which had previously been tested as efficient in vivo treatment on chlormethine intoxication. In an overview we propose that not only ionizing radiations and anticancer drugs, but also promoters and initiators of cancer might all generate free radicals, in turn triggering oxidative processes generating endogenous peroxides, then probably amplifying the deleterious biological response. The possible limitations of drug therapies decreasing peroxide generation are presented.

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Authors and Affiliations

  1. Unite de Radiobiochimie, Centre de Recherches du Service de Santé des Armées, 24 Avenue des Maquis du Grésivaudan, B.P. 87, F-38700, La Tronche, Grenoble, France

    Pierre Bienvenu, Laurent Caron, Didier Gasparutto & Jean-François Kergonou

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  1. Pierre Bienvenu
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  2. Laurent Caron
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  3. Didier Gasparutto
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  4. Jean-François Kergonou
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Editors and Affiliations

  1. C.N.R.S., Institut Biomédical des Cordeliers, Université Pierre et Marie Curie, 15–21, Rue de l’Ecole de Médecine, F-75006, Paris, France

    Ingrid Emerit (Directeur de Recherche) (Directeur de Recherche)

  2. Department of Biochemistry and Biophysics, University of Pennsylvania, D-501 Richards Building, 19104-6089, Philadelphia, PA, USA

    Britton Chance

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© 1992 Birkhäuser Verlag Basel/Switzerland

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Bienvenu, P., Caron, L., Gasparutto, D., Kergonou, JF. (1992). Assessing and counteracting the prooxidant effects of anticancer drugs. In: Emerit, I., Chance, B. (eds) Free Radicals and Aging. EXS, vol 62. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7460-1_27

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  • DOI: https://doi.org/10.1007/978-3-0348-7460-1_27

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7462-5

  • Online ISBN: 978-3-0348-7460-1

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