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Peroxidase Induced Metabolism and Lipid Peroxide Scavenging by Antitumor Agents

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Antioxidants in Therapy and Preventive Medicine

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 264))

Abstract

Oxygen is often viewed as being synonymous with life. It is necessary for the living processes of mammals including humans. The arrest of breathing, apart from termination of other functions, is an evident sign of mammalian death. However, soon after death, the body begins to re-utilize oxygen and in a short period it consumes oxygen at much higher rate than in normal life processes. But this process no longer represents controlled biological oxidation. Rather it is uncontrolled autooxidation, peroxidation or free radical oxidation of polyunsaturated lipids. In recent years, interest has grown in the possible links between drug metabolic reactions and certain aspects of lipid biochemistry. Attention has been focused particularly on oxidative processes, namely those of lipid peroxidation and co-oxidation. Lipid peroxidation is now recognized as an important mediator of toxicity.1 Reactive oxygen species (Superoxide anion radical, hydroxyl radical, singlet oxygen and hydrogen peroxide) are produced during enzymatic oxidation of xenobiotics by cytochrome P-450 and other oxidoreductase systems.2

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Author information

Authors and Affiliations

  1. Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada, T6G 2G2

    Pawel Kolodziejczyk & J. William Lown

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  1. Pawel Kolodziejczyk
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  2. J. William Lown
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Editor information

Editors and Affiliations

  1. Centre National de la Recherche Scientifique, University of Paris, Paris, France

    Ingrid Emerit

  2. Dept. of Physiology Anatomy, University of California, Berkeley, Berkeley, California, 94720, USA

    Lester Packer

  3. Institut Gustave-Roussy, 94800, Villejuif, France

    Christian Auclair

  4. Groupe de Recherche Radicaux Libres, Institut Biomédical des Cordeliers, 15, Rue de l’Ecole de Médecine, 75006, Paris, France

    Ingrid Emerit

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© 1990 Plenum Press, New York

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Kolodziejczyk, P., Lown, J.W. (1990). Peroxidase Induced Metabolism and Lipid Peroxide Scavenging by Antitumor Agents. In: Emerit, I., Packer, L., Auclair, C. (eds) Antioxidants in Therapy and Preventive Medicine. Advances in Experimental Medicine and Biology, vol 264. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5730-8_51

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  • DOI: https://doi.org/10.1007/978-1-4684-5730-8_51

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5732-2

  • Online ISBN: 978-1-4684-5730-8

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