Abstract
Metallothioneins are naturally occurring, primarily and often exclusively zinc-containing metalloproteins of mammalian liver. Their presence in human liver was first demonstrated by Kägi and co-workers (1, 2), who found that these proteins are an abundant component of this tissue (0.002–0.01% of wet weight) and that they may contain as much as 10% of the total zinc of adult liver. This finding suggested that their primary physiological role in this organ should be sought in relation to the metabolism of zinc.
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References
Kägi, J.H.R. (1970) 8th International Congress of Biochemistry, Switzerland, Sept. 1970, Abstracts, pp. 130–131.
Bühler, R.H.O. and Kägi, J.H.R. (1974) FEBS Lett. 39, 229–234.
Kägi, J.H.R., Himmelhoch, S.R., Whanger, P.D., Bethune, J.L., and Vallee, B.L. (1974) J. Biol. Chem. 249, 3537–3542.
Pulido, P., Kägi, J.H.R., and Vallee, B.L. (1966) Biochemistry 5, 1768–1777.
Dayhoff, M.O. (1974) Fed. Proc. 33, 2314–2316.
Kissling, M.M. and Kägi, J.H.R. (1977) FEBS Lett. 82, 247–250.
Kojima, Y., Berger, C., and Kägi, J.H.R. (1979) This volume, PP. 153–161.
Bühler, R.H.O.(1974) Ph.D. thesis, Universität Zürich.
Kojima, Y., Berger, C., Vallee, B.L., and Kägi, J.H.R. (1976) Proc. Natl. Acad. Sci. USA 73, 3413–3417.
Zuckerkandl, E. and Pauling, L.(1965) In: “Evolving Genes and Proteins”, V. Bryson and H.J. Vogel eds., Academic Press, New York, pp. 97–166.
Margoliash, E. and Smith, E.L. (1965) In “Evolving Genes and Proteins”, V. Bryson and H.J. Vogeleds., Academic Press, New York, pp. 221–242.
Kimura, M. (1969) Proc. Natl. Acad. Sci. USA 63, 1181–1188.
King, J.L. and Jukes, T.H. (1969) Science 164, 788–798.
Boyer, S.H., Crosby, E.F., Noyes, A.N., Fuller, G.F., Leslie, S.E., Donaldson, L.J., Vrablik, G.R., Schaefer, E.W., und Thurmon, T.F. (1971) Biochemical Genetics 5, 405–448.
Houmard, J. and Drapeau, G.R. (1972) Proc. Natl. Acad. Sci. USA 69, 3506–3509.
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Kissling, M.M., Kägi, J.H.R. (1979). Amino Acid Sequence of Human Hepatic Metallothioneins. In: Kägi, J.H.R., Nordberg, M. (eds) Metallothionein. Experientia Supplementum, vol 34. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-6493-0_5
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DOI: https://doi.org/10.1007/978-3-0348-6493-0_5
Publisher Name: Birkhäuser, Basel
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