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Reductive Stress and Male Infertility

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Oxidative Stress and Toxicity in Reproductive Biology and Medicine

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1391))

Abstract

Male infertility research and clinical advances had vast progress in the last few decades. Strong research evidence underpinned the concepts of oxidative stress (OS)-mediated male reproductive disruptions, which bear answers to several cases of idiopathic male infertility. Antioxidant treatment held the prime solution for OS-mediated male infertility. But excess use of antioxidants is challenged by the research breakthrough that reductive stress also predisposes to male infertility, resolutely instituting that any biological extremes of the redox spectrum are deleterious to male fertility. Superfluity of reducing agents may hinder essential oxidation mechanisms, affecting physiological homeostasis. These mechanisms need to be explicated and updated time and again to identify the fine thread between OS-mediated male infertility treatment and induction of reductive stress. This chapter thus presents the evidence-based concepts pertaining to the antioxidants actions to combat OS-induced male infertility, the mechanism of induction of reductive stress and its impact on male reproduction.

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Authors and Affiliations

  1. Physiology Unit, Department of Biomedical Sciences, College of Medicine, Gulf Medical University, Ajman, UAE

    Pallav Sengupta

  2. School of Medical Sciences, Bharath Institute of Higher Education and Research (BIHER), Chennai, India

    Sulagna Dutta

  3. Department of Medical Physiology, College of Medicine, University of Babylon, Hillah, Iraq

    Ahmed T. Alahmar

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  1. Pallav Sengupta
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  2. Sulagna Dutta
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  3. Ahmed T. Alahmar
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  1. Department of Life Science and Bioinformatics, Assam University, Silchar, India

    Shubhadeep Roychoudhury

  2. Department of Bioproducts and Biosystems, School of Chemical Engineering, Aalto University, ESPOO, Finland

    Kavindra Kumar Kesari

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Sengupta, P., Dutta, S., Alahmar, A.T. (2022). Reductive Stress and Male Infertility. In: Roychoudhury, S., Kesari, K.K. (eds) Oxidative Stress and Toxicity in Reproductive Biology and Medicine. Advances in Experimental Medicine and Biology, vol 1391. Springer, Cham. https://doi.org/10.1007/978-3-031-12966-7_17

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