Heat Shock Factors in Protein Quality Control and Spermatogenesis

Nelson, Vinod K.; Paul, Sourav; Roychoudhury, Shubhadeep; Oyeyemi, Ifeoluwa Temitayo; Mandal, Subhash C.; Kumar, N.; Ravichandiran, Valuathan; Pal, Mahadeb

doi:10.1007/978-3-031-12966-7_11

Vinod K. Nelson^9,10,
Sourav Paul¹¹,
Shubhadeep Roychoudhury ORCID: orcid.org/0000-0003-4174-1852¹²,
Ifeoluwa Temitayo Oyeyemi¹³,
Subhash C. Mandal¹¹,
N. Kumar⁹,
Valuathan Ravichandiran^14,15 &
…
Mahadeb Pal¹⁶

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1391))

647 Accesses
2 Citations

Abstract

Proper regulation of cellular protein quality control is crucial for cellular health. It appears that the protein quality control machinery is subjected to distinct regulation in different cellular contexts such as in somatic cells and in germ cells. Heat shock factors (HSFs) play critical role in the control of quality of cellular proteins through controlling expression of many genes encoding different proteins including those for inducible protein chaperones. Mammalian cells exert distinct mechanism of cellular functions through maintenance of tissue-specific HSFs. Here, we have discussed different HSFs and their functions including those during spermatogenesis. We have also discussed the different heat shock proteins induced by the HSFs and their activities in those contexts. We have also identified several small molecule activators and inhibitors of HSFs from different sources reported so far.

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Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Hajipur, India
Vinod K. Nelson & N. Kumar
Department of Pharmaceutical Chemistry, Raghavendra Institute of Pharmaceutical Education and Research, Anantapuramu, India
Vinod K. Nelson
Department of Pharmaceutical Technology, Pharmacognosy and Phytotherapy Laboratory, Jadavpur University, Kolkata, India
Sourav Paul & Subhash C. Mandal
Department of Life Science and Bioinformatics, Assam University, Silchar, India
Shubhadeep Roychoudhury
Department of Biological Sciences, University of Medical Sciences, Ondo City, Nigeria
Ifeoluwa Temitayo Oyeyemi
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Hajipur, India
Valuathan Ravichandiran
National Institute of Pharmaceutical Education and Research, Kolkata, India
Valuathan Ravichandiran
Division of Molecular Medicine, Bose Institute, Kolkata, India
Mahadeb Pal

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Shubhadeep Roychoudhury
Department of Bioproducts and Biosystems, School of Chemical Engineering, Aalto University, ESPOO, Finland
Kavindra Kumar Kesari

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Nelson, V.K. et al. (2022). Heat Shock Factors in Protein Quality Control and Spermatogenesis. In: Roychoudhury, S., Kesari, K.K. (eds) Oxidative Stress and Toxicity in Reproductive Biology and Medicine. Advances in Experimental Medicine and Biology, vol 1391. Springer, Cham. https://doi.org/10.1007/978-3-031-12966-7_11

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