Abstract
MicroRNAs (miRNAs) are important components of the signaling cascades that mediate and regulate tumor suppression exerted by p53. This review illustrates some of the main principles that underlie the mechanisms by which miRNAs participate in p53’s function and how they were identified. Furthermore, the current status of the research on the connection between p53 and miRNAs, as well as alterations in the p53/miRNA pathways found in cancer will be summarized and discussed. In addition, experimental and bioinformatic approaches which can be applied to study the connection between p53 and miRNAs are described. Although, some of the central miRNA-encoding genes that mediate the effects of p53, such as the miR-34 and miR-200 families, have been identified, much more analyses remain to be performed to fully elucidate the connections between p53 and miRNAs.
Analysis of the p53/microRNA network in cancer” by Kaller, Hünten, Siemens and Hermeking), please include the footnote to the abstract” This chapter is an update of the previously published work: Hünten S., Siemens H., Kaller M., Hermeking H. (2013) The p53/microRNA Network in Cancer: Experimental and Bioinformatics Approaches. In: Schmitz U., Wolkenhauer O., Vera J. (eds) MicroRNA Cancer Regulation
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Acknowledgments
We thank the members of the Hermeking Lab for discussions. Work in HH’s lab is supported by the Wilhelm-Sander-Stiftung, the Rudolf-Bartling-Stiftung, the Deutsche Krebshilfe, and the Deutsche Forschungsgemeinschaft (DFG).
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Kaller, M., Hünten, S., Siemens, H., Hermeking, H. (2022). Analysis of the p53/microRNA Network in Cancer. In: Schmitz, U., Wolkenhauer, O., Vera-González, J. (eds) Systems Biology of MicroRNAs in Cancer. Advances in Experimental Medicine and Biology, vol 1385. Springer, Cham. https://doi.org/10.1007/978-3-031-08356-3_7
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