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Sensors and Biosensors in Organs-on-a-Chip Platforms

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Microfluidics and Biosensors in Cancer Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1379))

Abstract

Biosensors represent a powerful analytical tool for analyzing biomolecular interactions with the potential to achieve real-time quantitative analysis with high accuracy using low sample volumes, minimum sample pretreatment with high potential for the development of in situ and highly integrated monitoring platforms. Considering these advantages, their use in cell-culture systems has increased over the last few years. Between the different technologies for cell culture, organs-on-a-chip (OOCs) represent a novel technology that tries to mimic an organ’s functionality by combining tissue engineering/organoid with microfluidics. Although there are still challenges to achieving OOC models with high organ mimicking relevance, these devices can offer effective models for drug treatment development by identifying drug targets, screening toxicity, and determining the potential effects of drugs in living beings. Consequently, in the future, we might replace animal studies by offering more ethical test models. Considering the relevance that different physiological and biochemical parameters have in the correct functionality of cells, sensing and biosensing platforms can offer an effective way for the real-time monitoring of physiological parameters and, in our opinion, more relevant, the secretion of biomarkers such as cytokines, growth factors, and others related with the influence of drugs or other types of stimulus in cell metabolism. Keeping this concept in mind, in this chapter, we focus on describing the potential use of sensors and biosensors in OOC devices to achieve fully integrated platforms that monitor physiological parameters and cell metabolism.

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Change history

  • 14 August 2022

    This book was inadvertently published with an incorrect spelling of the author’s name in Chapter 3 as Sheeza Mugal whereas it should be Sheeza Mughal.

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Acknowledgments

This project received financial support from the European Research Council program under grants ERC-StG-DAMOC (714317), the European Commission under FET-open program BLOC project (GA-863037), the Spanish Ministry of Economy and Competitiveness, through the “Severo Ochoa” Program for Centres of Excellence in R & D (SEV-2016–2019) and “Retos de investigación: Proyectos I+D+i” (TEC2017-83716-C2-2-R), the CERCA Programme/Generalitat de Catalunya (2017-SGR-1079) and Fundación Bancaria “la Caixa”- Obra Social “la Caixa” (project IBEC-La Caixa Healthy Ageing) to Javier Ramón-Azcón. Gerardo A. Lopez-Muñoz acknowledges SECTEI (Secretaria de Educación, Ciencia, Tecnología e Innovación de la Ciudad de México) for Postdoctoral Fellowship SECTEI/143/2019 and CM-SECTEI/013/2021.

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Authors and Affiliations

  1. Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, Barcelona, Spain

    Gerardo A. Lopez-Muñoz, Sheeza Mughal & Javier Ramón-Azcón

  2. ICREA-Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain

    Javier Ramón-Azcón

Authors
  1. Gerardo A. Lopez-Muñoz
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  2. Sheeza Mughal
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  3. Javier Ramón-Azcón
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Corresponding author

Correspondence to Javier Ramón-Azcón .

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Editors and Affiliations

  1. 3B’s Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics at the University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, ICVS/3B’s – PT Government Associate Laboratory, Braga/Guimarães, Portugal

    David Caballero

  2. 3B’s Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics at the University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, ICVS/3B’s – PT Government Associate Laboratory, Braga/Guimarães, Portugal

    Subhas C. Kundu

  3. 3B’s Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics at the University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, ICVS/3B’s – PT Government Associate Laboratory, Braga/Guimarães, Portugal

    Rui L. Reis

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Lopez-Muñoz, G.A., Mughal, S., Ramón-Azcón, J. (2022). Sensors and Biosensors in Organs-on-a-Chip Platforms. In: Caballero, D., Kundu, S.C., Reis, R.L. (eds) Microfluidics and Biosensors in Cancer Research. Advances in Experimental Medicine and Biology, vol 1379. Springer, Cham. https://doi.org/10.1007/978-3-031-04039-9_3

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