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Vascularization in Oral and Maxillofacial Tissue Engineering

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Tissue Engineering in Oral and Maxillofacial Surgery

Abstract

The oral and maxillofacial region is a complex area which contains multiple soft and hard tissue types. While tissue engineering techniques have made significant progress in the regeneration of oral and craniofacial structures, several challenges remain before these techniques can be considered as an appropriate clinical method. One of the major challenges in engineering clinically usable tissue constructs is the inclusion of vascular networks inside the tissues to provide a constant source of oxygen and nutrients to preserve tissue viability. This chapter provides an overview of the mechanisms involved in tissue vascularization and angiogenesis, outlines existing reconstructive techniques and limitations, and reviews current vascularization strategies that have been adopted for tissues.

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Notes

  1. 1.

    The term biocompatible is defined here as the ability of a biomaterial to perform its desired function with respect to a medical therapy, without eliciting any undesirable local or systemic effects in the recipient or beneficiary of that therapy, but generating the most appropriate beneficial cellular or tissue response in that specific situation, and optimizing the clinically relevant performance of that therapy.

  2. 2.

    Shear thinning is the non-Newtonian behavior of fluids whose viscosity decreases under shear strain, thus allowing controlled extrusion from a syringe, and retain their shape fidelity after print.

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Authors and Affiliations

  1. Vascularization Lab, Department of Biomechanical Engineering, Faculty of Engineering Technology, Technical Medical Centre, University of Twente, Enschede, The Netherlands

    Fabian Stein, Vasileios Trikalitis, Jeroen Rouwkema & Nasim Salehi-Nik

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  1. Fabian Stein
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  2. Vasileios Trikalitis
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Correspondence to Jeroen Rouwkema .

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  1. Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

    Riitta Seppänen-Kaijansinkko

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Stein, F., Trikalitis, V., Rouwkema, J., Salehi-Nik, N. (2019). Vascularization in Oral and Maxillofacial Tissue Engineering. In: Seppänen-Kaijansinkko, R. (eds) Tissue Engineering in Oral and Maxillofacial Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-24517-7_8

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