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Delayed Neurologic Complications of Brain Tumor Therapy

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Oncology of CNS Tumors

Abstract

Radiation therapy and chemotherapy have an important role in the treatment of patients with primary and metastatic brain tumors. However, delayed neurologic complications from these therapies compromise outcomes and impair quality of life, especially in long-term survivors. Common adverse effects of cranial irradiation and chemotherapy include cognitive dysfunction, injury to white matter, progressive brain atrophy, neurovascular complications, and secondary tumors. Treatment options remain limited, but various management strategies are being evaluated in clinical trials. The present chapter summarizes important aspects of each of these challenging adverse effects. Potential mechanisms of neural injury are discussed and management options highlighted.

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Authors and Affiliations

  1. Department of Neurology, Center for Neuro-Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA

    Jörg Dietrich & Michael W. Parsons

  2. Department of Neurosurgery, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany

    Sebastian F. Winter

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Correspondence to Jörg Dietrich .

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Editors and Affiliations

  1. Department of Neurosurgery, University of Munich Department of Neurosurgery, Munich, Germany

    Jörg-Christian Tonn

  2. Dana-Farber Cancer Institute Center, Harvard University, Boston, USA

    David A. Reardon

  3. SickKids Hospital, University of Toronto, Toronto, ON, Canada

    James T. Rutka

  4. Department of Neurosurgery, University of Hamburg, Hamburg, Germany

    Manfred Westphal

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Dietrich, J., Winter, S.F., Parsons, M.W. (2019). Delayed Neurologic Complications of Brain Tumor Therapy. In: Tonn, JC., Reardon, D., Rutka, J., Westphal, M. (eds) Oncology of CNS Tumors. Springer, Cham. https://doi.org/10.1007/978-3-030-04152-6_42

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