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HORDE: Comprehensive Resource for Olfactory Receptor Genomics

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Olfactory Receptors

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1003))

Abstract

Olfactory receptors (ORs) constitute the largest gene family in the mammalian genome. The existence of these proteins underlies the nature of, and variability in, odorant perception. The Human Olfactory Receptor Data Explorer (HORDE, http://genome.weizmann.ac.il/horde/) is a free online resource, which presents a complete compendium of all OR genes and pseudogenes in the genome of human and four other vertebrates. HORDE includes three parts: (1) an automated pipeline, which mines OR gene and pseudogene sequences out of complete genomes, and generates gene symbols based on sequence similarity; (2) a card generator that obtains and displays annotative information on individual ORs retrieved from external databases and relevant studies; and (3) a search engine that allows user retrieval of OR information. For human ORs, HORDE specifically addresses the universe of interindividual variation, as obtained from several sources, including whole genome sequences made possible by next-generation sequencing. This encompasses single nucleotide polymorphisms (SNP) and copy number variation (CNV), including deleterious mutational events. HORDE also hosts a number of tools designed specifically to assist in the study of OR evolution and function. In this chapter, we describe the status of HORDE (build #43). We also discuss plans for future enhancements and a road map for HORDE to become a better community-based bioinformatics tool. We highlight HORDE’s role as a major research tool in the study of an expanding cohort of OR repertoires.

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Acknowledgements

This research was supported by the Israel Science Foundation Heritage fund, LifeMap Sciences Inc. California (USA), as well as the Crown Human Genome Center and the Nella and Leon Benoziyo Center for Neurological Diseases at the Weizmann Institute of Science.

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Authors and Affiliations

  1. Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel

    Tsviya Olender, Noam Nativ & Doron Lancet

  2. The Crown Human Genome Center, Weizmann Institute of Science, Rehovot, Israel

    Tsviya Olender, Noam Nativ & Doron Lancet

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  1. Tsviya Olender
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  2. Noam Nativ
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  3. Doron Lancet
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Editors and Affiliations

  1. , Department of Genetics, University of Alabama, Birmingham, 20th Street South 720, Birmingham, 35294, Alabama, USA

    Chiquito J. Crasto

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Olender, T., Nativ, N., Lancet, D. (2013). HORDE: Comprehensive Resource for Olfactory Receptor Genomics. In: Crasto, C. (eds) Olfactory Receptors. Methods in Molecular Biology, vol 1003. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-377-0_2

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  • DOI: https://doi.org/10.1007/978-1-62703-377-0_2

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-376-3

  • Online ISBN: 978-1-62703-377-0

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