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Hematopoietic Stem Cell Biology

  • Book
  • © 2010

Overview

Editors:
  1. Motonari Kondo

    1. Duke University Medical Center, Durham, USA

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  • Each chapter is precisely described by the expert in the field
  • Will provide a basic information of hematopoietic stem cell and its differentiation as a prototype of the Stem Cell Biology
  • Clinical relevance of the biology of the hematopoietic stem cells is also provided
  • Includes supplementary material: sn.pub/extras

Part of the book series: Stem Cell Biology and Regenerative Medicine (STEMCELL)

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Table of contents (8 chapters)

  1. Front Matter

    Pages 1-11
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  2. Principles of Hematopoietic Stem Cell Biology

    • Hideo Ema, Toshihiro Kobayashi, Hiromitsu Nakauchi
    Pages 1-36

  3. Hematopoietic Stem Cells and Their Niche

    • Hiroko Iwasaki, Toshio Suda
    Pages 37-55

  4. Hematopoietic Stem Cells and Somatic Stem Cells

    • Kah Yong Tan, Francis S. Kim, Amy J. Wagers, Shane R. Mayack
    Pages 57-92

  5. Developmental Biology of Mammalian T-Cell Progenitors: From Early Lymphoid Progenitors to Thymus-Colonizing Cells

    • Sophie Ezine, Laetitia Gautreau, Aude Parcelier, Bruno Canque
    Pages 93-116

  6. GATA1 and GATA2 Function in Hematopoietic Differentiation

    • Takashi Moriguchi, Mikiko Suzuki, James Douglas Engel, Masayuki Yamamoto
    Pages 117-142

  7. Role of the IL-7 Receptor in γδ T-Cell Development from Hematopoietic Stem Cells

    • Koichi Ikuta, Shizue Tani-ichi
    Pages 143-159

  8. Dendritic Cell Homeostasis: Physiology and Impact on Disease

    • Miriam Merad, Markus G. Manz
    Pages 161-212

  9. Wnt in Hematopoietic and Leukemic Stem Cells

    • Kim-Hien T. Dao, H. M. Jamieson Catriona
    Pages 213-243

  10. Back Matter

    Pages 1-7
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Keywords

About this book

In the summer of 1988, my developmental biology professor announced to the class that hematopoietic stem cells (HSCs) had finally been purified. Somehow, I never forgot the professor’s words. When I started working in Dr. Irv Weissman’s labo- tory at Stanford as a postdoctoral fellow, I realized that the findings mentioned by the professor were from Weissman’s laboratory and had been published in a 1988 edition of the journal Science. It has been over 20 years since the publication of that seminal paper, and since then tremendous advances in understanding the biology and maturation of HSCs, namely the process of hematopoiesis, which includes lymphocyte development, have been made. These discoveries were made possible in part by advancements in technology. For example, recent availability of user friendly fluorescence activated cell sorting (FACS) machines and monoclonal an- bodies with a variety of fluorescent labels has allowed more scientists to sort and analyze rare populations in the bone marrow, such as HSCs. All classes of hematopoietic cells are derived from HSCs. Stem cell biology draws enormous attention not only from scientists, but also from ordinary people because of the tremendous potential for development of new therapeutic application to diseases that currently lack any type of effective therapy. Thus, this type of “regenerative medicine” is a relatively new and attractive field in both basic science and clinical medicine.

Reviews

From the reviews:

“The text is exceptionally well written by 23 contributors from Japan, the United States, France, and Switzerland­­–– all experts in their respective fields of hematopoietic stem cell biology and lymphocyte physiology. … Hematopoietic Stem Cell Biology will be most helpful and interesting to readers wanting a current update of the field. It is well indexed and well referenced, although it includes few figures, schemas, or photographs to help elucidate the text.” (Paulette Mehta, Journal of the American Medical Association, Vol. 304 (18), November, 2010)

Editors and Affiliations

  • Duke University Medical Center, Durham, USA

    Motonari Kondo

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