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GATA1 and GATA2 Function in Hematopoietic Differentiation

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Hematopoietic Stem Cell Biology

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

Transcription factors GATA1 and GATA2 play essential roles in gene regulation during hematopoietic differentiation. GATA1 is essential for the survival and terminal differentiation of erythroid, megakaryocytic, eosinophilic, and mast cell precursors, whereas GATA2 primarily regulates the proliferation and maintenance of immature progenitors in hematopoietic cells. The activities of GATA1 and GATA2 are regulated in a cell-type–specific manner, and their expression is strictly controlled during hematopoietic development and differentiation. A series of recent investigations highlight the strong correlation between GATA1 misexpression and human hematopoietic disorders, including inherited anemia, thrombocytopenia, and leukemia. This review summarizes current progress in functional analyses of GATA1 and GATA2, their relationship to blood diseases, and regulatory mechanisms that control their gene expression.

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Acknowledgments

We thank Dr. Jon Maher for help and critical reading of the manuscript. This work is supported in part by grants-in-aid from the Ministry of Education, Culture, Sports, Science and Technology, Japan Science and Technology Corporation, National Institutes of Health, the Naito Foundation, and Takeda Science Foundation.

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Authors and Affiliations

  1. Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai, 980-8575, Japan

    Takashi Moriguchi, Mikiko Suzuki & Masayuki Yamamoto

  2. Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, 48109-2220, USA

    James Douglas Engel

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  1. Takashi Moriguchi
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  2. Mikiko Suzuki
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  3. James Douglas Engel
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  4. Masayuki Yamamoto
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Correspondence to Masayuki Yamamoto .

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  1. Duke University Medical Center, Research Drive, Durham, 27710, North Carolina, USA

    Motonari Kondo

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Moriguchi, T., Suzuki, M., Engel, J.D., Yamamoto, M. (2010). GATA1 and GATA2 Function in Hematopoietic Differentiation. In: Kondo, M. (eds) Hematopoietic Stem Cell Biology. Stem Cell Biology and Regenerative Medicine. Humana Press. https://doi.org/10.1007/978-1-60327-347-3_5

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