Abstract
The cold pressor test is a reliable pain model in which subjects submerge their hands and forearms into ice water while onset to pain, pain intensity, and tolerance are assessed. Although originally developed as a model for hypertension, the paradigm leads to development of reproducible pain responses allowing assessment to analgesic medications. However, analgesic variability to various medications has been observed. A recent study suggests that methodological discrepancies may contribute to such inconsistencies. The model may be more reproducible by utilizing consistent protocols.
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Modir, J.G., Wallace, M.S. (2010). Human Experimental Pain Models 2: The Cold Pressor Model. In: Szallasi, A. (eds) Analgesia. Methods in Molecular Biology, vol 617. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-323-7_13
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DOI: https://doi.org/10.1007/978-1-60327-323-7_13
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Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-60327-322-0
Online ISBN: 978-1-60327-323-7
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