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Interactions Between Stroma and Epithelium in Breast Cancer

Implications for Tumor Genesis, Growth, and Progression

  • Chapter
Endocrinology of Breast Cancer

Part of the book series: Contemporary Endocrinology ((COE,volume 11))

Abstract

Breast cancers are traditionally considered epithelial malignancies. In reality, breast cancers, like normal breast itself, are complex tissues with many interdependent components. Although it is the epithelial cell from ductal or lobular elements within the breast which undergoes malignant transformation, no breast cancer can grow beyond microscopic size and become clinically significant without a complex and dynamic interaction with the surrounding stroma. Stromal elements, consisting of matrix proteins, fibroblasts, vascular elements, and their myriad cellular products, are critical determinants of the growth and malignant behavior of a breast cancer. Ongoing growth and dissemination of a breast malignancy requires complex, but poorly understood, interactions between these elements.

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Authors
  1. Kevin J. Cullen MD
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  2. Sahana S. Kaup
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  3. Audrey A. Rasmussen MS
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Editors and Affiliations

  1. College of Medicine, The Pennsylvania State University, Hershey, PA, USA

    Andrea Manni MD

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Cullen, K.J., Kaup, S.S., Rasmussen, A.A. (1999). Interactions Between Stroma and Epithelium in Breast Cancer. In: Manni, A. (eds) Endocrinology of Breast Cancer. Contemporary Endocrinology, vol 11. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-699-7_11

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  • DOI: https://doi.org/10.1007/978-1-59259-699-7_11

  • Publisher Name: Humana Press, Totowa, NJ

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