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Diffusion-Weighted Magnetic Resonance Imaging

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Preclinical MRI

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1718))

Abstract

Magnetic resonance imaging (MRI) is a technique based on the contents and relaxation features of water in tissues. In basic MRI sequences, diffusion phenomenon of water molecules is not taken into account although it has a notable influence in the relaxation times, and therefore in the signal intensity of images. In fact, MRI techniques that take advantage of water diffusion have experienced a huge development in last years. Diffusion-weighted imaging (DWI) has spectacularly evolved reaching nowadays a great impact both in clinical and preclinical imaging—especially in the neuroimaging field—and in basic research. We present here a protocol to perform DWI studies in a high-field preclinical setup.

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Acknowledgments

This work was supported by grant SAF2014-53739-R. IG held a predoctoral contract from Ministerio de Economía, Indrustria y Competitividad (MINECO) of Spain. DC held a postdoctoral contract from Consejo Superior de Investigaciones Científicas (CSIC).

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Authors and Affiliations

  1. Instituto de Investigaciones Biomédicas “Alberto Sols”, CSIC/UAM, Madrid, Spain

    Irene Guadilla, Daniel Calle & Pilar López-Larrubia

Authors
  1. Irene Guadilla
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  2. Daniel Calle
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  3. Pilar López-Larrubia
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Corresponding author

Correspondence to Pilar López-Larrubia .

Editor information

Editors and Affiliations

  1. BIONAND, Andalusian Centre for Nanomedicine and Biotechnology, Junta de Andalucía, Universidad de Málaga, Málaga, Spain

    María Luisa García Martín

  2. Instituto de Investigaciones Biomédicas “Alberto Sols”, CSIC/UAM, Madrid, Spain

    Pilar López Larrubia

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Guadilla, I., Calle, D., López-Larrubia, P. (2018). Diffusion-Weighted Magnetic Resonance Imaging. In: García Martín, M., López Larrubia, P. (eds) Preclinical MRI. Methods in Molecular Biology, vol 1718. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7531-0_6

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  • DOI: https://doi.org/10.1007/978-1-4939-7531-0_6

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7530-3

  • Online ISBN: 978-1-4939-7531-0

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