Abstract
Oxidative damage is an early event in neurodegenerative disorders such as Alzheimer disease. To increase oxidative stress in AD-related mouse models is essential to study early mechanisms involved in the physiopathology of these diseases. In this chapter, we describe an experimental mouse model of transient and acute hyperthermic stress to induce in vivo an increase of oxidative stress in the brain of any kind of wild-type or transgenic mouse.
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Acknowledgments
This work was supported by French government funding from the Agence Nationale de la Recherche MALZ EPITAUDNA grant and by LabEx (Excellence Laboratory), DISTALZ (Development of Innovative Strategies for a Transdisciplinary, Approach, to, Alzheimer’s, Disease),(INSERM((Institut National de la santé et de la recherche médicale), LMCU (Lille Métropole Communauté urbaine), Région Nord/Pas de Calais, and FEDER (Fonds Européen de Développement Economique et Régional).
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Chauderlier, A., Delattre, L., Buée, L., Galas, MC. (2017). In Vivo Hyperthermic Stress Model: An Easy Tool to Study the Effects of Oxidative Stress on Neuronal Tau Functionality in Mouse Brain. In: Smet-Nocca, C. (eds) Tau Protein. Methods in Molecular Biology, vol 1523. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6598-4_25
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DOI: https://doi.org/10.1007/978-1-4939-6598-4_25
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Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4939-6596-0
Online ISBN: 978-1-4939-6598-4
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