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Neurological Diseases from a Systems Medicine Point of View

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Systems Medicine

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1386))

Abstract

The difficulty to understand, diagnose, and treat neurological disorders stems from the great complexity of the central nervous system on different levels of physiological granularity. The individual components, their interactions, and dynamics involved in brain development and function can be represented as molecular, cellular, or functional networks, where diseases are perturbations of networks. These networks can become a useful research tool in investigating neurological disorders if they are properly tailored to reflect corresponding mechanisms. Here, we review approaches to construct networks specific for neurological disorders describing disease-related pathology on different scales: the molecular, cellular, and brain level. We also briefly discuss cross-scale network analysis as a necessary integrator of these scales.

If you look at the anatomy, the structure, the function, there's nothing in the universe that’s more beautiful, that’s more complex, than the human brain. Keith Black

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Authors and Affiliations

  1. Luxembourg Centre for Systems Biomedicine (LCSB), Université du Luxembourg, 7, Avenue des Hauts-Fourneaux, L-4362, Esch-Belval, Luxembourg

    Marek Ostaszewski, Alexander Skupin & Rudi Balling

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  1. Marek Ostaszewski
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  2. Alexander Skupin
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  3. Rudi Balling
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  1. Dept of Systems Biology & Bioinformatics, University of Rostock, Rostock, Germany

    Ulf Schmitz

  2. Dept of Systems Biology & Bioinformatics, University of Rostock, Rostock, Germany

    Olaf Wolkenhauer

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Ostaszewski, M., Skupin, A., Balling, R. (2016). Neurological Diseases from a Systems Medicine Point of View. In: Schmitz, U., Wolkenhauer, O. (eds) Systems Medicine. Methods in Molecular Biology, vol 1386. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3283-2_11

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