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Breast Cancer Stem Cells: Current Advances and Clinical Implications

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Mammary Stem Cells

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1293))

Abstract

There is substantial evidence that many cancers, including breast cancer, are driven by a population of cells that display stem cell properties. These cells, termed cancer stem cells (CSCs) or tumor initiating cells, not only drive tumor initiation and growth but also mediate tumor metastasis and therapeutic resistance. In this chapter, we summarize current advances in CSC research with a major focus on breast CSCs (BCSCs). We review the prevailing methods to isolate and characterize BCSCs and recent evidence documenting their cellular origins and phenotypic plasticity that enables them to transition between mesenchymal and epithelial-like states. We describe in vitro and clinical evidence that these cells mediate metastasis and treatment resistance in breast cancer, the development of novel strategies to isolate circulating tumor cells (CTCs) that contain CSCs and the use of patient-derived xenograft (PDX) models in preclinical breast cancer research. Lastly, we highlight several signaling pathways that regulate BCSC self-renewal and describe clinical implications of targeting these cells for breast cancer treatment. The development of strategies to effectively target BCSCs has the potential to significantly improve the outcomes for patients with breast cancer.

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Authors and Affiliations

  1. Department of Internal Medicine, University of Michigan, 2800 Plymouth Rd, 026 NCRC 335S, Ann Arbor, MI, 49108, USA

    Ming Luo, Shawn G. Clouthier, Yadwinder Deol, Ebrahim Azizi & Max S. Wicha

  2. School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China

    Suling Liu

  3. Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA

    Sunitha Nagrath

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  4. Suling Liu
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  5. Sunitha Nagrath
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  6. Ebrahim Azizi
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  7. Max S. Wicha
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Corresponding author

Correspondence to Max S. Wicha .

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Editors and Affiliations

  1. CIC bioGUNE, Technological Park of Bizkaia, Derio, Spain

    Maria del Mar Vivanco

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Luo, M. et al. (2015). Breast Cancer Stem Cells: Current Advances and Clinical Implications. In: Vivanco, M. (eds) Mammary Stem Cells. Methods in Molecular Biology, vol 1293. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2519-3_1

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  • DOI: https://doi.org/10.1007/978-1-4939-2519-3_1

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-2518-6

  • Online ISBN: 978-1-4939-2519-3

  • eBook Packages: Springer Protocols

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