Abstract
Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency of newborns, especially those born prematurely. Mesenchymal stem cell (MSC) therapy has shown efficacy in protection against various forms of tissue injury, and we have demonstrated efficacy in experimental NEC. However, few studies have been performed to establish a safe and effective method of intravenous MSC infusion for newborns. Here we described a safe, non-traumatic, and effective technique for systemic MSC transplantation in newborn rats.
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Acknowledgements
This work was supported by NIH R01 DK74611 and NIH R01 GM61193 (GEB).
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Yang, J., Su, Y., Besner, G.E. (2014). Stem Cell Therapy for Necrotizing Enterocolitis: Innovative Techniques and Procedures for Pediatric Translational Research. In: Christ, B., Oerlecke, J., Stock, P. (eds) Animal Models for Stem Cell Therapy. Methods in Molecular Biology, vol 1213. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1453-1_11
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DOI: https://doi.org/10.1007/978-1-4939-1453-1_11
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