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The Participation of Mesenchymal Stem Cells in Tumor Stroma Formation and Their Application as Targeted-Gene Delivery Vehicles

  • Chapter
Bone Marrow-Derived Progenitors

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 180))

Abstract

Recent evidence suggests that mesenchymal stem cells (MSC) selectively proliferate to tumors and contribute to the formation of tumor-associated stroma. The biological rationale for tumor recruitment of MSC remains unclear but may represent an effort of the host to blunt tumor cell growth and improve survival. There is mounting experimental evidence that normal stromal cells can revert malignant cell behavior, and separate studies have demonstrated that stromal cells can enhance tumor progression after acquisition of tumor-like genetic lesions. Together, these observations support the rationale for modifying normal MSC to deliver therapeutic proteins directly into the tumor microenvironment. Modified MSC can produce high concentrations of antitumor proteins directly within the Tumor mass, which have been shown to blunt tumor growth kinetics in experimental animal model systems. In this chapter we will address the biological properties of MSC within the tumor microenvironment and discuss the potential use of MSC and other bone marrow-derived cell populations as delivery vehicles for antitumor proteins.

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Authors and Affiliations

  1. Center for Childhood Cancer, Columbus Children’s Research Institute, 700 Children’s Drive, Columbus, OH, 43205, USA

    B. Hall

  2. Department of Blood and Marrow Transplantation, Unit 81, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX, 77030, USA

    M. Andreeff & F. Marini

Authors
  1. B. Hall
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  2. M. Andreeff
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  3. F. Marini
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Corresponding author

Correspondence to F. Marini .

Editor information

Editors and Affiliations

  1. Cardiovascular Disease Boehringer Ingelheim, Pharmaceuticals, Inc., 175 Briar Ridge Road, Ridgefield, CT, 06877, USA

    Katalin Kauser MD, PhD, DSc (Director) (Director)

  2. Department of Internal Medicine III, University of Frankfurt, Theodor-Stern-Kai 7, D-60590, Frankfurt a. Main

    Andreas-Michael Zeiher MD (Professor Molecular Cardiology) (Professor Molecular Cardiology)

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© 2007 Springer-Verlag Berlin Heidelberg

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Hall, B., Andreeff, M., Marini, F. (2007). The Participation of Mesenchymal Stem Cells in Tumor Stroma Formation and Their Application as Targeted-Gene Delivery Vehicles. In: Kauser, K., Zeiher, AM. (eds) Bone Marrow-Derived Progenitors. Handbook of Experimental Pharmacology, vol 180. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68976-8_12

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