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Ubiquitin and the Molecular Pathology of Human Disease

  • Chapter
Ubiquitin and the Biology of the Cell

Abstract

The role of ubiquitin in cell stress and its central involvement in eliminating shortlived, abnormal or damaged proteins make it an important molecule for investigations of pathological cellular processes. Several areas of human pathology have been linked with the ubiquitin system:

  • Chronic degenerative diseases of the nervous system and muscle

  • Acute cellular injury associated with a cell stress response

  • Cell atrophy

  • Programmed cell death

  • Tumor biology and turnover of oncogene products

  • Processing of peptides for antigen presentation to the immune system

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Author information

Authors and Affiliations

  1. Department of Biochemistry, University of Nottingham Medical School, Queen’s Medical Centre, Nottingham, NG7 2UH, UK

    R. John Mayer & Michael Landon

  2. Department of Clinical Laboratory Sciences, University of Nottingham Medical School, Queen’s Medical Centre, Nottingham, NG7 2UH, UK

    James Lowe

Authors
  1. R. John Mayer
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  2. Michael Landon
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  3. James Lowe
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Editor information

Editors and Affiliations

  1. Research Institute of Molecular Pathology, Vienna, Austria

    Jan-Michael Peters

  2. Institute of Zoology, University of Mainz, Mainz, Germany

    J. Robin Harris

  3. Harvard Medical School, Boston, Massachusetts, USA

    Daniel Finley

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© 1998 Springer Science+Business Media New York

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Mayer, R.J., Landon, M., Lowe, J. (1998). Ubiquitin and the Molecular Pathology of Human Disease. In: Peters, JM., Harris, J.R., Finley, D. (eds) Ubiquitin and the Biology of the Cell. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1922-9_15

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  • DOI: https://doi.org/10.1007/978-1-4899-1922-9_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1924-3

  • Online ISBN: 978-1-4899-1922-9

  • eBook Packages: Springer Book Archive

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