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Cytokines in Streptococcal Infections

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Streptococci and the Host

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 418))

Abstract

Cytokines play a pivotal role in the anti-infectious process. They are essential in the cross-talk between B lymphocytes, T lymphocytes and antigen-presenting cells which contribute to the specific immune response. In addition, they are involved in the activation of the microbicidal activities of phagocytic cells, in the recruitment of the circulating leukocytes towards the infectious foci and stimulate hematopoiesis, leading to an increased number of cellular actors. However, the same beneficial cytokines like the tumor necrosis factor-α (TNFα) and interleukin-1 (IL-1) are also involved in inflammatory reaction. Their exacerbated production contributes to the development of acute respiratory distress syndrome (ARDS), multiple organ failure (MOF) and poor outcome in patients with sepsis syndrome.

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References

  1. Abe J, Forrester J, Nakahara T, Lafferty JA, Kotzin BL, Leung DYM. Selective stimulation of human T cells with streptococcal erythrogenic toxins A and B. J Immunol 1991; 146:3747–50.

    PubMed  CAS  Google Scholar 

  2. Alouf JE, Geoffroy C. The family of antigenically-related cholesterol-binding (“sulfhydryl-activated”) cytolytic toxins. In Sourcebook of Bacterial Toxins (Alouf JE, and Freer JN Eds) London: Academic Press, 1991.

    Google Scholar 

  3. Bayston K, Tomlinson M, Cohen J. In-vitro stimulation of TNF-alpha from human whole blood by cell-free supernatants of gram-positive bacteria. Cytokine 1992;4:397–402.

    Article  PubMed  CAS  Google Scholar 

  4. Benabdelmoumene S, Dumont S, Petit C, Poindron P, Wachsmann D, Klein JP. Activation of human monocytes by Streptococcus mutans serotype f polysaccharide: immunoglobulin G Fc receptor expression and tumor necrosis factor and interleukin-1 production. Infect Immun 1991;59:3261–6.

    PubMed  CAS  Google Scholar 

  5. Benton KA, Everson MP, Briles DE. A pneumolysin-negative mutant of Streptococcus pneumoniae causes chronic bacteremia rather than acute sepsis in mice. Infect Immun 1995;63:448–55.

    PubMed  CAS  Google Scholar 

  6. Beutler B, Milsark IW, Cerami AC. Passive immunization against cahectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science 1985;229:869–71.

    Article  PubMed  CAS  Google Scholar 

  7. Braun MA, Gerlach D, Hartwig UF, et al. Stimulation of human T cells by streptococcal “superantigen” erythrogenic toxins (scarlet fever toxins). J Immunol 1993; 150:2457–66.

    PubMed  CAS  Google Scholar 

  8. Cavaillon JM. Controversies surrounding current therapies for sepsis syndrome. Bull Inst Pasteur 1995;93:21–41.

    Article  CAS  Google Scholar 

  9. Cavaillon JM, Alouf JE. Mitogenicity of streptococcal extracellular products and antagonism with concanavalin A. Immunol Lett 1982;5:317–22.

    Article  PubMed  CAS  Google Scholar 

  10. Cavaillon JM, Geoffroy C, Alouf JE. Purification of two extracellular streptococcal mitogens and their effects on human, rabbit, and mouse lymphocytes. J Clin Lab Immunol 1979;2:155–63.

    Google Scholar 

  11. Cavaillon JM, Leclerc C, Alouf JE. Polyclonal antibody-forming cell activation and immunomodulation of the invitro immune response induced by streptococcal extracellular products. Cell Immunol 1983;76:200–6.

    Article  PubMed  CAS  Google Scholar 

  12. Cavaillon JM, Munoz C, Fitting C, Misset B, Carlet J. Circulating cytokines: the tip of the iceberg? Circ Shock 1992;38:145–52.

    PubMed  CAS  Google Scholar 

  13. Cavaillon JM, Rivière Y, Svab J, Montagnier L, Alouf JE. Induction of interferon by streptococcus pyogenes extracellular products. Immunol Lett 1982;5:323–26.

    Article  PubMed  CAS  Google Scholar 

  14. Cleveland M, Gorham J, Murphy T, Tuomanen E, KMM. Lipoteichoic acid preparations of Gram positive bacteria induce interleukin-12 through a CD14-dependent pathway. Infect Immun 1996;64:1906–1912.

    PubMed  CAS  Google Scholar 

  15. Cusumano V, Genovese F, Mancuso G, Carbone M, Fera MT, Teti G. Interleukin-10 protects neonatal mice from lethal group B streptococcal infection. Infect Immun 1996;64:2850–52.

    PubMed  CAS  Google Scholar 

  16. Fast DJ, Schlievert PM, Nelson RD. Toxic shock syndrome-associated staphylococcal and streptococcal pyrogenic toxins are potent inducers of tumor necrosis factor production. Infect Immun 1989;57:291–4.

    PubMed  CAS  Google Scholar 

  17. Follows GA, Munk ME, Gatrill AJ, Conradt P, Kaufmann SH. Gamma interferon and interleukin 2, but not interleukin 4, are detectable in gamma/delta T-cell cultures after activation with bacteria. Infect Immun 1992;60:1229–31.

    PubMed  CAS  Google Scholar 

  18. Geoffroy C, Müller-Alouf H, Champagne E, Cavaillon J-M, Alouf JE. Identification of a new extracellular mitogen from group A streptococci. Zbl Bakteriol 1994;suppl.24:90–91.

    Google Scholar 

  19. Gerlach D, Knoll H, Kohler W, Ozegowski JH, Hribalova V. Isolation and characterization of erythrogenic toxins. V. Communication: identity of erythrogenic toxin type B and streptococcal proteinase precursor. Zentralbl Bakteriol Mikrobiol Hyg [a] 1983;255:221–33.

    CAS  Google Scholar 

  20. Gerlach DH, Alouf JE, Moravek L, Pavlik M, Köhler W. The characterization of two new low molecular weight proteins (LMPs) from Streptococcus pyogenes. Zbl Bakteriol 1992;277:1–9.

    Article  CAS  Google Scholar 

  21. Gonzalo J, Gonzales-Garcia A, Kalland T, Hedlund G, Martinez A, G K. Linomide, a novel immunomodulator that prevents death in four models of septic shock. Eur J Immunol 1993;23:2372–74.

    Article  PubMed  CAS  Google Scholar 

  22. Hackett SP, Stevens DL. Streptococcal toxic shock syndrome: synthesis of tumor necrosis factor and interleukin-1 by monocytes stimulated with pyrogenic exotoxin A and streptolysin O. J Infect Dis 1992; 165:879–85.

    Article  PubMed  CAS  Google Scholar 

  23. Hackett SP, Stevens DL. Superantigens associated with staphylococcal and streptococcal toxic shock syndrome are potent inducers of tumor necrosis factor-beta synthesis. J Infect Dis 1993; 168:232–5.

    Article  PubMed  CAS  Google Scholar 

  24. Helfgott DC, Tatter SB, Santhanam U, et al. Multiple forms of IFN-beta 2/IL-6 in serum and body fluids during acute bacterial infection. J Immunol 1989; 142:948–53.

    PubMed  CAS  Google Scholar 

  25. Holm SE, Norrby A, Bergholm AM, Norgren M. Aspects of pathogenesis of serious group A streptococcal infection in Sweden, 1998–89. J Infect Dis 1992; 166:37–37.

    Google Scholar 

  26. Houldsworth S, Andrew PW, Mitchell TJ. Pneumolysin stimulates production of tumor necrosis factor alpha and interleukin-1 beta by human mononuclear phagocytes. Infect Immun 1994;62:1501–3.

    PubMed  CAS  Google Scholar 

  27. Hribalova V, Castrova A, Perarek J. Influence of antilymphocyte and antipolymorphonuclear sera on the pyrogenic effects of scarlet fever toxin. Folia Microbiol 1979;24:428–34.

    Article  CAS  Google Scholar 

  28. Ichimura O, Suzuki S, Saito M, Sugawara Y, Ishida N. Augmentation of interleukin 1 and interleukin 2 production by OK-432. Int J Immunopharmacol 1985;7:263–70.

    Article  PubMed  CAS  Google Scholar 

  29. Imanishi K, Akatsuka H, Inada K, Uchiyama T. IFN-gamma-stimulated human vascular endothelial cells function as accessory cells for superantigen-induced TNF production in human T cells. Int Arch Allergy Immunol 1995; 106:163–5.

    Article  PubMed  CAS  Google Scholar 

  30. Imanishi K, Igarashi H, Uchiyama T. Activation of murine T cells by streptococcal pyrogenic exotoxin type A. J Immunol 1990; 145:3170–76.

    PubMed  CAS  Google Scholar 

  31. Iwasaki M, Igarashi H, Hinuma Y, Yutsudo T. Cloning, characterization and overexpression of a Streptococcus pyogenes gene encoding a new type of mitogenic factor. FEBS 1993;331:187–192.

    Article  CAS  Google Scholar 

  32. Kapur V, Maffei JT, Greer R, Li LL, Adams GJ, Musser JM. Vaccination xith streptococcal extracellular cysteine protease (Interleukin-1β convertase) protects mice against challenge with heterologous group A streptococci. Microbial Pathogen. 1994; 16:443–450.

    Article  CAS  Google Scholar 

  33. Kapur V, Majesky MW, Li LL, Black RA, Musser JM. Cleavage of interleukin-1β precursor to produce active IL-1β by a converted cysteine protease from Streptococcus pyogenes. Proc. Natl. Acad. Sci. USA 1993;90:7676–7680.

    Article  PubMed  CAS  Google Scholar 

  34. Kotb M, Majumdar G, Tomai M, Beachey E. Accesory cell-independent stimulation of human T cells by streptococcal M protein superantigen. J Immunol 1990; 145:1332–36.

    PubMed  CAS  Google Scholar 

  35. Kotb M, Ohnishi H, Majumdar G, et al. Temporal relationship of cytokine release by peripheral blood mononuclear cells stimulated by the streptococcal superantigen pep M5. Infect Immun 1993;61:1194–201.

    PubMed  CAS  Google Scholar 

  36. Le Roy D, Morand P, Lengacher S, et al. Streptococcus mitis cell walls and lipopolysaccharide induce lethality in D-galactosamine sensitized mice by a tumor necrosis factor-dependent pathway. Infect Immun 1996;64:1846–1849.

    PubMed  Google Scholar 

  37. Leonard B, Schlievert P. Immune cell lethality induced by streptococci pyrogenic exotoxin A and endotoxin. Infect Immun 1992;60:3747–55.

    PubMed  CAS  Google Scholar 

  38. Mancuso G, Tomasello F, Migliardo M, et al. Beneficial effects of interleukin-6 in neonatal mouse models of group B streptococcal disease. Infect Immun 1994;62:4997–5002.

    PubMed  CAS  Google Scholar 

  39. Mancuso G, Tomasello F, Ofek I, Teti G. Anti-lipoteichoic acid antibodies enhance release of cytokines by monocytes sensitized with lipoteichoic acid. Infect Immun 1994;62:1470–73.

    PubMed  CAS  Google Scholar 

  40. Mancuso G, Tomasello F, von Hunolstein C, Orefici G, Teti G. Induction of tumor necrosis factor alpha by the group and type specific polysaccharide from type III group B streptococci. Infect Immun 1994; 62: 2748–2753.

    PubMed  CAS  Google Scholar 

  41. Martin RA, Silva AT, Cohen J. Effect of anti-TNF-alpha treatment in an antibiotic treated murine model of shock due to Streptococcus pyogenes. Ferns Microbiol Lett 1993; 110:175–8.

    CAS  Google Scholar 

  42. Matsushita K, Fujimaki W, Kato H, et al. Immunopathological activities of extracellular products of Streptococcus mitis, particularly a superantigenic fraction. Infect Immun 1995;63:785–93.

    PubMed  CAS  Google Scholar 

  43. Minami A, Fujimoto K, Ozaki Y, Nakamura S. Augmentation of host resistance to microbial infections by recombinant human interleukin-1 alpha. Infect Immun 1988; 56: 3116–20.

    PubMed  CAS  Google Scholar 

  44. Mollick JA, Miller JM, Cook RG, Grossman D, Rich RR. A novel superantigen isolated from pathogenic strains of Streptococcus pyogenes with aminoterminal homolgy to staphylococcal enterooxins B and C. J Clin Invest 1993;92:710–719.

    Article  PubMed  CAS  Google Scholar 

  45. Müller-Alouf H, Alouf JE, Gerlach D, Fitting C, Cavaillon JM. Cytokine production by murine cells activated by erythrogenic toxin type A superantigen of Streptococcus pyogenes. Immunobiology 1992; 186:435–48.

    Article  PubMed  Google Scholar 

  46. Müller-Alouf H, Alouf JE, Gerlach D, Ozegowski JH, Fitting C, Cavaillon JM. Comparative study of cytokine release by human peripheral blood mononuclear cells stimulated with Streptococcus pyogenes superantigen erythrogenic toxins, heat-killed streptococci and lipopolysaccharide. Infect Immun 1994; 62: 4915–21.

    PubMed  Google Scholar 

  47. Müller-Alouf H, Alouf J, Gerlach D, Ozegowski J, Fitting C, Cavaillon J-M. Human pro-and anti-inflammatory cytokine patterns induced by Streptococcus pyogenes erythrogenic (pyrogenic) exotoxin A and C superantigens. Infect Immun 1996;64:1450–53.

    PubMed  Google Scholar 

  48. Muñoz C, Misset B, Fitting C, Bleriot JP, Carlet J, Cavaillon JM. Dissociation between plasma and monocyte-associated cytokines during sepsis. Eur J Immunol 1991;21:2177–84.

    Article  PubMed  Google Scholar 

  49. Nadal D, Lauener R, Braegger C, et al. T cell activation and cytokine release in streptococcal toxic shock like syndrome. J Pediatr. 1993; 122:727–9.

    Article  PubMed  CAS  Google Scholar 

  50. Norrby A, Norgren M, Holm SE. Elevated levels of interleukin 6 in serum of patients with serious group A streptococcal infections [letter]. Infection 1992;20:369–70.

    Article  PubMed  CAS  Google Scholar 

  51. Norrby-Teglund A, Norgren M, Holm SE, Andersson U, Andersson J. Similar cytokine induction profiles of a novel streptococcal exotoxin, MF, and pyrogenic exotoxins A and B. Infect Immun 1994;62:3731–8.

    PubMed  CAS  Google Scholar 

  52. Norrby-Teglund A, Pauksens K, Norgren M, Holm SE. Correlation between serum TNF alpha and IL6 levels and severity of group A streptococcal infections. Scand J Infect Dis 1995;27:125–30.

    Article  PubMed  CAS  Google Scholar 

  53. Ohga S, Nishizaki M, Nagashima T, Ueda K. Association between fever and serum interleukin-6 levels in children with group A β-hemolytic streptococcal infection. J. Therm. Biol. 1994; 19:91–96.

    Article  Google Scholar 

  54. Peat E, Augustine N, Drummond W, Bohnsack J, Hill H. Effects of fibronectin and group B streptococci on tumour necrosi factor-alpha produciton by human cultured-derived macrophages. Immunology 1995;84:440–5.

    PubMed  CAS  Google Scholar 

  55. Riesenfeld-Orn I, Wolpe S, Garcia-Bustos JF, Hoffmann MK, Tuomanen E. Production of interleukin-1 but not tumor necrosis factor by human monocytes stimulated with pneumococcal cell surface components. Infect Immun 1989;57:1890–3.

    PubMed  CAS  Google Scholar 

  56. Rink L, Luhm J, Koester M, Kirchner H. Induction of a cytokine network by superantigens with parallel Th1 and Th2 stimulation. J Interferon Cytokine Res 1996; 16:41–47.

    Article  PubMed  CAS  Google Scholar 

  57. Rowen JL, Smith CW, Edwards MS. Group B streptococci elicit leukotriene B4 and interleukin-8 from human monocytes: neonates exhibit a diminished response. J Infect Dis 1995; 172:420–6.

    Article  PubMed  CAS  Google Scholar 

  58. Saukkonen K, Sande S, Ciffe C, et al. The role of cytokines in the generation of inflammation and tissue damage in experimental Gram-positive meningitis. J. Exp. Med. 1990; 171:439–448.

    Article  PubMed  CAS  Google Scholar 

  59. Schmidt KH, Gerlach D, Wollweber L, et al. Mitogenicity of M5 protein extracted from Sttreptococcus pyogenes cells is due to streptococcal pyrogenic exotoxin C and mitogenic factor MF. Infect Immun 1995;63:4569–4575.

    PubMed  CAS  Google Scholar 

  60. Shi J, Goodband R, Chengappa M, et al. Influence of interleukin-1 on neutrophil function and resistance to streptoccocus suis in neonatal pigs. J Leuk Biol 1994;56:88–94.

    CAS  Google Scholar 

  61. Simpson SQ, Singh R, Bice DE. Heat-killed pneumococci and pneumococcal capsular polysaccharides stimulate tumor necrosis factor-alpha production by murine macrophages. Am J Respir Cell Mol Biol 1994; 10:284–9.

    Article  PubMed  CAS  Google Scholar 

  62. Skansen-Saphir U, Andersson J, Bjork L, Andersson U. Lymphokine production induced by streptococcal pyrogenic exotoxin-A is selectively down-regulated by pooled human IgG. Eur J Immunol 1994;24:916–22.

    Article  PubMed  CAS  Google Scholar 

  63. Soell M, Holveck F, Scholler M, Wachsmann RD, Klein JP. Binding of Streptococcus mutans SR protein to human monocytes: production of tumor necrosis factor, interleukin 1, and interleukin 6. Infect Immun 1994; 62: 1805–12.

    PubMed  CAS  Google Scholar 

  64. Soell M, Lett E, Holveck F, Scholler M, Wachsmann D, Klein JP. Activation of human monocytes by streptococcal rhamnose glucose polymers is mediated by CD14 antigen, and mannan binding protein inhibits TNF-alpha release. J Immunol 1995; 154:851–60.

    PubMed  CAS  Google Scholar 

  65. Soto A, Evans T, Cohen J. Proinflammatory cytokine production by human peripheral blood mononuclear cells stimulated with cell-free supernatants of viridans streptococci. Cytokine 1996;8:300–4.

    Article  PubMed  CAS  Google Scholar 

  66. Sriskandan S, Evans TJ, Cohen J. Bacterial superantigen-induced human lymphocyte responses are nitric oxide dependent and mediated by IL-12 and IFN-gamma. J Immunol 1996; 156.

    Google Scholar 

  67. Sriskandan S, Moyes D, Buttery L, et al. Streptococcal pyrogenic exotoxin a release, distribution, and role in a murine model of fasciitis and multiorgan failure due to Streptococcus pyogenes. J Infect Dis 1996;173:1399–1407.

    Article  PubMed  CAS  Google Scholar 

  68. Standiford T, Arenberg D, Danforth J, Kunkel S, VanOtteren G, Strieter R. Lipoteichoic acid induces secretion of interleukin-8 from human blood monocytes: a cellular and molecular analysis. Infect Immun 1994;62:119–25.

    PubMed  CAS  Google Scholar 

  69. Stevens D, Bryant A, Hackett S, et al. Group A streptococcal bacteremia: the role of tumor necrosis factor in shock and organ failure. J Infect Dis 1996; 173:619–26.

    Article  PubMed  CAS  Google Scholar 

  70. Takada H, Kawabata Y, Arakaki R, et al. Molecular and structural requirements of a lipoteichoic acid from Enterococcus hirae ATCC 9790 for cytokine-inducing, antitumor, and antigenic activities. Infect Immun 1995;63:57–65.

    PubMed  CAS  Google Scholar 

  71. Takada H, Kawabata Y, Tamura M, et al. Cytokine induction by extracellular products of oral viridans group streptococci. Infect Immun 1993;61:5252–60.

    PubMed  CAS  Google Scholar 

  72. Taranta A. Lymphocyte mitogens of streptococcal origin. Ann N Y Acad Sci 1974;226:431–42.

    Google Scholar 

  73. Teti G, Mancuso G, Tomasello F. Cytokine appearance and effects of anti-tumor necrosis factor alpha antibodies in a neonatal rat model of group B streptococcal infection. Infect Immun 1993;61:227–35.

    PubMed  CAS  Google Scholar 

  74. Teti G, Mancuso G, Tomasello F, Chiofalo MS. Production of tumor necrosis factor-alpha and interleukin-6 in mice infected with group B streptococci. Circ Shock 1992;38:138–44.

    PubMed  CAS  Google Scholar 

  75. Tomai MA, Beachey EH, Majumdar G, Kotb M. Metabolically active antigen presenting cells are required for human T cell proliferation in response to the superantigen streptococcal M protein. Fems Microbiol Immunol 1992;4:155–64.

    Article  PubMed  CAS  Google Scholar 

  76. Tonew E, Gerlach D, Tonew M, Kohler W. Induktion von immuninterferon durch erythrogene toxine A und B des streptococcus pyogenes. Zentralbl Bakteriol Mikrobiol Hyg [a] 1982;252:463–71.

    CAS  Google Scholar 

  77. Tsuchiya I, Kasahara T, Yamashita K, et al. Induction of inflammatory cytokines in the pleural effusion of cancer patients after the administration of an immunomodulator, OK-432: role of IL-8 for neutrophil infiltration. Cytokine 1993;5:595–603.

    Article  PubMed  CAS  Google Scholar 

  78. Ueta E, Umazume M, Yamamoto T, Osaki T. Enhancement of polymorphonuclear leukocyte (PMN) function by OK-432. Int J Immunopharmacol 1994; 16:7–17.

    Article  PubMed  CAS  Google Scholar 

  79. Weigent DA, Huff TL, Peterson JW, Stanton GJ, Baron S. Role of interferon in streptococcal infection in the mouse. Microbial Pathogen. 1986; 1:399–407.

    Article  CAS  Google Scholar 

  80. Wheeler J, Givner L. Therapeutic use of recombinant human granulocyte-macrophage colony stimulating factor in neonatal rats with type III group B streptococcal sepsis. J Infect Dis 1992; 165:938–941.

    Article  PubMed  CAS  Google Scholar 

  81. Williams P, Bohnsack J, Augustine N, Drummond W, Rubens C, Hill H. Production of tumor necrosis factor by human cells in vitro and in vivo induced by group B streptococci. J Pediatr 1993; 123:292–300.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Institut Pasteur, Unité d’Immuno-Allergie, 28 rue Dr Roux, 75015, Paris, France

    Jean-Marc Cavaillon

  2. Institut Pasteur, 1 rue Prof. Calmette, 59019, Lille, France

    Heide Müller-Alouf & Joseph E. Alouf

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  1. Jean-Marc Cavaillon
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  2. Heide Müller-Alouf
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  3. Joseph E. Alouf
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Editors and Affiliations

  1. Institut Pasteur, Paris, France

    Thea Horaud

  2. Hôtel Dieu Hospital, University Paris VI, Paris, France

    Anne Bouvet

  3. Henri Mondor Hospital, University Paris XII, Creteil, France

    Roland Leclercq

  4. Hospital of Fleyriat, Bourg en Bresse, France

    Henri de Montclos

  5. University Paul Sabatier and National Center of Scientific Research, Toulouse, France

    Michel Sicard

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Cavaillon, JM., Müller-Alouf, H., Alouf, J.E. (1997). Cytokines in Streptococcal Infections. In: Horaud, T., Bouvet, A., Leclercq, R., de Montclos, H., Sicard, M. (eds) Streptococci and the Host. Advances in Experimental Medicine and Biology, vol 418. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1825-3_206

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