Abstract
The role played by lymphocytes in the pyretic response to scarlet fever toxin (ET) was studied in two using antilymphocyte serum (ALS). Two i.v. injections of ALS inhibited the pyretic response to a subsequent ET injection in rabbits. The course of endotoxin fever remained uninfluenced by ALS. Antipolymorphonuclear serum had no effect on the pyretic response to either of the toxins. Pretreatment with ALS also inhibited the skin reaction after i.d. injection of ET. These findings are further evidence a mediating role of lymphocytes in the biological effects of ET, among other things in the release of endogenous pyrogen.
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Airó R., Mihaillescu E., Astaldi G., Meardi G.: Skin reactions to phytohaemagglutinin.Lancet1, 899 (1967).
Atkins E., Bodel P., Francis L.: Release of an endogenous pyrogenin vitro from rabbit mononuclear cells.J.Exp.Med.126, 357 (1967).
Atkins E., Feldman J. D., Francis L., Hursch E.: Studies on the mechanism of fever accompanying delayed hypersensitivity. The role of the sensitized lymphocyte.J.Exp.Med.135, 1113 (1972).
Atkins E., Francis L.: Role of lymphocytes in the pyrogenic response: comparison of endotoxin with specific antigen and the nonspecific mitogen, concanavalin A.J.Inf.Dis.128, S277 (1973).
Bodel P., Atkins E.: Release of endogenous pyrogen by human monocytes.New Engl.J.Med.276, 1002 (1967).
Burgio G. R., Astaldi G., Genova R., Curtoni E.: Cytology of skin reactions to different inoculated substances. (Tuberculin, streptokinase, lipopolysaccharide ofS. typhi, phytohaemagglutinin and pokeweed mitogen).Pathol. Europ.4, 138 (1969).
Castrová A., Pekárek J., Johanovský J.: The influencing of the systemic hypersensitivity fever reaction with antilymphocyte and antipolymorphonuclear sera.Z.Immun.-Forsch.141, 332 (1971).
Castrová A., Pekárek J., Johanovský J.: Pyrogenic activity of antilymphocyte and of antipolymorphonuclear sera.Z.Immun.-Forsch.144, 221 (1972).
Chao P., Francis L., Atkins E.: The release of an endogenous pyrogen from guinea pig leukocytesin vitro. A new model for investigating the role of lymphocytes in fevers induced by antigen in hosts with delayed hypersensitivity.J.Exp.Med.145, 1288 (1977).
Dinarello C. A., Bodel P., Atkins E.: The role of the liver in the production of fever and in pyrogenic tolerance.Trans. Assoc. Amer.Phys.81, 334 (1968).
Gillman S. M., Bornstein D. L., Wood W. B., Jr.: Studies on the pathogenesis of fever. VIII. Further observations on the role of endogenous pyrogen in endotoxin fever.J.Exp.Med.114, 729 (1961).
Herion J. C., Walker R. I., Palmer J. G.: Endotoxin fever in granulocytopenic animals.J.Exp.Med.113, 1115 (1961).
Hříbalová V., Schuh V.: The pyrogenic effect of scarlet fever toxin. III. The effect of cortisone on the pyrogenic, lethal and dermal activity of scarlet fever toxin.Folia Microbiol.12., 477 (1967).
Hříbalová V., Pospíšil M.: Lymphocyte-stimulating activity of scarlet fever toxin.Experientia29, 704 (1973).
Hříbalová V., Pospíšil M.: The character of mitogenic activity of scarlet fever toxin. 11th Ann.Meet. Czech.Soc.Microbiol., Špindlerův Mlýn 1974. Abstr.:Folia Microbiol.20, 84 (1978).
Inderbitzin T.: The relationship of lymphocytes, delayed cutaneous allergic reactions and histamine.Int.Arch.Allergy Appl.Immunol.8, 150 (1956).
Lauce E. M.: The selective action of antilymphocyte serum on recirculating lymphocytes: A review of the evidence and alternatives.Clin.Exp.Immunol.6, 789 (1970).
Lawrence H. S., Landy M. (Eds.):Mediators of Cellular Immunity. Academic Press, New York 1969.
Monaco A. P., Wood M. L., Russell P. S.: Some effects of purified heterologous antihuman lymphocyte serum in man.Transplantation5, 1106 (1967).
Nagaya H., Sieker H. O.: Lymphopenic effect of anti-lymphocyte serum.Proc.Soc.Exp.Biol.Med.121, 722 (1966).
Nauciel C.: Mitogenic activity of purified streptococcal erythrogenic toxin on lymphocytes.Ann.Immunol.124C, 383 (1973).
Oppenheim J. J., Rosenstreich D. L. (Eds):Mitogens in Jmmunobiology. Academic Press, New York 1976.
Pekárek J., Švejcar J., Hříbalová V., Johanovský J.: The production of migration inhibitory factor (MIF) in rabbit lymphocytes by other than immunological mechanism.Folia Microbiol.18, 393 (1973).
Root R. K., Nordlund J. J., Wolff S. M.: Factors affecting the quantitative production and assay of human leukocytic pyrogen.J.Lab.Clin.Med.75, 679 (1970).
Schrek R., Stefani S. S.: Lymphocytic and intradermal reactions to phytohemagglutinin.Fed.Proc.22, 428 (1963).
Schuh V., Hříbalová V.: The pyrogenic effect of scarlet fever toxin. II. Leukocytic pyrogen formation induced by scarlet fever toxin orSalmonella paratyphi B endotoxin.Folia Microbiol.11 112 (1966).
Schuh V., Hříbalová V., Malý V.: The paohophysiological effect of scarlet fever toxin. I. Its effect on the white blood picture.Folia Microbiol.13, 106 (1968).
Stock A. H.: Studies on hemolytic streptococcus. IV. Further purification and concentration of scarlet fever toxin.J.Biol.Chem.142, 777 (1942).
Trebichavský I., HříBAlOvá V., Pospíšil M.: In vitro lymphocyte stimulation by scarlet fever toxin.Folia Biol.24, 101 (1978).
Waksman B. H., Arbouys S., Arnason B. G.: The use of specific “lymphocyte” antisera to inhibit hypersensitive reactions of the “delayed” type.J.Exp.Med.114, 997 (1961).
Watson D. W., Kim Y. B.: Modification of host responses to bacterial endotoxins. I. Specificity of pyrogenic tolerance and the role of hypersensitivity in pyrogenicity, lethality, and skin reactivity.J.Exp.Med.118 425 (1963).
Woodruff M. F. A.: Antilymphocytic serum and its mode of action.Transplant.Proc.3, 34 (1971).
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Part V of the seriesThe pyrogenic effect of scarlet fever toxin. Part IV:Yale J.Biol.Med. 43, 31 (1970).
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Hříbalová, V., Castrová, A. & Pekárek, J. Influence of antilymphocyte and antipolymorphonuclear sera on the pyrogenic effect of scarlet fever toxin. Folia Microbiol 24, 428–434 (1979). https://doi.org/10.1007/BF02927126
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DOI: https://doi.org/10.1007/BF02927126