Abstract
The discovery that taurine treatment reverses arrhythmias associated with epinephrine- and digoxin-induced toxicity stimulated research into the myocardial actions of taurine and eventually led to the hypothesis that taurine must have an important physiological function in the heart (10,14, 25,28). Two subsequent lines of evidence have provided the most compelling support for this hypothesis. First, cardiac taurine levels are extremely high and are maintained by an energy-dependent transport process (14,29). Second, exposure of the heart to a medium containing taurine results in a significant change in myocardial energy and calcium metabolism (5–7,15, 18,20,28).
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References
Azari, J., Brumbaugh, P., and Huxtable, R.J., 1980, Prophylaxis by taurine in the hearts of cardiomyopathic hamsters, J. Mol. Cell. Cardiol., 12:1353–1366.
Azuma, J., Sawamura, A., Awata, N., Hasegawa, H., Ogura, K., Harada, H., Ohata, H., Yamauchi, K., Kishimoto, S., Yamagami, T., Ueda, E., and Ishiyama, T., 1983, Double blind randomized crossover trial of taurine in congestive heart failure, Curr. Therap. Res., 34:543–557.
Azuma, J., Takihara, K., Awata, N., Ohata, H., Sawamura, A., Harada, H., and Kishimoto, S., 1984, Benefician effect of taurine on congestive heart failure induced by chronic aortic regurgitation in rabbits, Res. Commun. Chem. Pathol. Pharmacol., 45:261–270.
Bunger, R., Swindall, B., Brodie, D., Zdunek, D., Stiegler, H., and Walter, G., 1986, Pyruvate attenuation of hypoxia damage in isolated working guinea pig heart, J. Mol. Cell. Cardiol., 18:423–438.
Chovan, J.P., Kulakowski, E.C., Sheakowski, S., and Schaffer, S.W., 1980, Calcium regulation by the low-affinity taurine binding sites of cardiac sarcolemma, Mol. Pharmacol., 17:295–300.
Dolara, P., Agresti, A., Giotti, A., and Pasquini, G., 1973, Effect of taurine on calcium kinetics of guinea pig heart, Eur. J. Pharmacol., 24:352–358.
Franconi, F., Martini, F., Stendardi, I., Matucci, R., Zilletti, L., and Giotti, A., 1982, Effect of taurine on calcium levels and contractility in guinea pig ventricular strips, Biochem. Pharmacol., 31:3181–3185.
Franconi, F., Stendardi, I., Matucci, R., Bennardini, F., Baccaro, C., and Giotti, A., A protective effect of taurine on hypoxic and reoxygenated guinea pig heart, in: “Taurine: Biological Actions and Clinical Perspectives”, S.S. Oja, L. Ahtee, P. Kontro, and M.K. Paasonen, eds., Alan R. Liss, Inc., New York (1985), pp. 177–182.
Gaull, G.E., 1986, Taurine as a conditionally essential nutrient in man, J. Am. Coll. Nutr., 5:121–125.
Grosso, D.S., and Bressler, R., 1976, Taurine and cardiac physiology, Biochem. Pharmacol., 25:2227–2232.
Hayes, K.C., Stephen, Z.F., and Sturman, J.A., 1980, growth depression in taurine-depleted infant monkeys, J. Nutr., 110:2058–2064.
Huxtable, R.J., Regulation of taurine in the heart, in: “Taurine and Neurological Disorders”, A. Barbeau and R.J. Huxtable, eds., Raven Press, New York (1985), pp. 5–17.
Huxtable, R.J., Laird, H.E.II, and Lippincott, S.E., 1979, The transport of taurine in the heart and the rapid depletion of tissue taurine content by guanidinoethyl sulfonate, J. Pharmacol. Exp. Therap., 211:465–471.
Huxtable, R.J., and Sebring, L.A., Cardiovascular actions of taurine, in: “Sulfur Amino Acids: Biochemical and Clinical Aspects”, K. Kuriyama, R.J. Huxtable and H. Iwata, Eds., Alan R. Lisa, Inc., New York (1983), pp. 5–37.
Iwata, H., and Fujimoto, S., Potentiation by taurine of the inotropic effect of ouabain and the content of intracellular Ca2+ and taurine in the heart, Experientia, 32:1559–1561.
Kramer, J.H., Chovan, J.P., and Schaffer, S.W., 1981, Effect of taurine on calcium paradox and ischemic heart failure, Am. J. Physiol., 240:H238–H246.
Lake, N., 1983, taurine depletion of lactating rats: effects on developing pups, Neurochem. Res., 8:881–887.
McBroom, M.J., and Welty, J.D., 1977, Effects of taurine on heart calcium in the cardiomyopathic hamster, J. Mol. Cell. Cardiol., 9:853–858.
Meerson, F.Z., Kagan, V.E., Kozlov, Y.P., Belkina, L.M., and Arkhipenko, Y.V., 1982, The role of lipid peroxidation in pathogenesis of ischemic damage and the antioxidant protection of the heart, Basic Res. Cardiol., 77:465–485.
Mozaffari, M.S., Tan, B.H., Lucia, M.A., and Schaffer, S.W., 1986, Effect of drug-induced taurine depletion on cardiac contractility and metabolism, Biochem. Pharmacol. 35:985–989.
Nayler, W.G., Poole-Wilson, P.A., and Williams, A., 1979, Hypoxia and calcium, J. Mol. Cell. Cardiol., 11:683–706.
Neely, J.R., and Grotyohann, L.W., 1984, Role of glycolytic products in damage to ischemic myocardium, Circ. Res., 55:816–824.
Pasantes-Morales, H., Quesada, O., Carabez, A., and Huxtable, R.J., 1983, Effects of the taurine transport antagonist, guanidinoethane sulfonate, and β-alanine on the morphology of rat retina, J. Neurosci. Res., 9:135–143.
Pasantes-Morales, H., Wright, C.E., and Gaull, G.E., 1985, Taurine protests lymphoblastoid cells from iron-ascorbate Induced damage, Biochem. Pharmacol., 34:2205–2207.
Read, W.O., and Welty, J.D., 1963, Effect of taurine on epinephrine and digoxin induced irregularities of the dog heart, J. Pharmacol. Exp. Therap., 139:283–289.
Rovetto, M.J., Lamberton, W.F., and Neely, J.R., 1975, Mechanisms of glycolytic inhibition in ischemic rat hearts, Circ. Res., 37:742–751.
Sawamura, A., Sperelakis, N., and Azuma, J., 1986, Protective effect of taurine against decline of cardiac slow action potentials during hypoxia, Eur. J., Pharmacol., 120:235–239.
Schaffer, S.W., Kramer, J., and Chovan, J.P., 1980, Regulation of calcium homeostasis in the heart by taurine, Fed. Proc., 39:2691–2694.
Schaffer, S.W., Kulakowski, E.C., and Kramer, J.H., Taurine transport by reconstituted membrane vesicles, in: “Taurine in Nutrition and Neurology”, R.J. Huxtable and H. Pasantes-Morales, eds., Plenum Press, New York (1982), pp. 143–160.
Schmidt, S.Y., Taurine in retinas of taurine-deficient cats and RCS rats, in: “The Effects of Taurine on Excitable Tissues”, S.W. Schaffer, S.I. Baskin and J.J. Kocsis, Ed., Spectrum Publications, New York (1981), pp. 177–185.
Sebring, L.A., and Huxtable, R.J., 1985, Binding of taurine to cardiac sarcolemma and phospholiposomes, Fed. Proc, 44:2052.
Shaffer, J.E., and Kocsis, J.J., Methods of reducing tissue taurine levels, in: “The Effects of Taurine on Excitable Tissues”, S.W. Schaffer, S.I. Baskin and J.J. Kocsis, Eds., Spectrum Publications, Inc., New York (1981), pp. 219–229.
Sturman, J.A., Moretz, R.C., French, J.H., and Wisniewski, H.M., 1985, Postnatal taurine deficiency in the kitten results in a persistence of the cerebellular external granule cell layer: Correction by taurine feeding, J. Neurosci. Res., 13:521–528.
Vary, T.C., Angelaskos, E.T., and Schaffer, S.W., 1979, Relationship between adenine nucleotide metabolism and irreversible ischemic tissue damage in isolated perfused rat heart, Circ. Res., 45:218–225.
Welty, M.C., Welty, J.D., and McBroom, M.J., 1982, Effect of isoproterenol and taurine on heart calcium in normal and cardiomyopathic hamsters, J. Mol. Cell. Cardiol., 14:353–357.
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Schaffer, S.W., Allo, S., Mozaffari, M. (1987). Potentiation of Myocardial Ischemic Injury by Drug-Induced Taurine Depletion. In: Huxtable, R.J., Franconi, F., Giotti, A. (eds) The Biology of Taurine. Advances in Experimental Medicine and Biology, vol 217. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0405-8_16
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