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The Effect of Steroid Hormones on Gene Transcription

  • Chapter
Biological Regulation and Development

Abstract

Steroid hormones modulate the metabolism, differentiation, and growth of a large number of cell types in eukaryotic organisms. It is generally assumed that steroid hormones control some of these processes by regulating the transcription of specific genes. This topic is reviewed in the current chapter beginning with a discussion of the evidence that steroid hormones can alter gene transcription, enlarging on this topic with a discussion of the regulatory mechanisms and strategies that might be involved in this effect, and ending with a discussion of the coordinate regulation of gene transcription by steroid hormones. Although the regulation of specific gene transcription is undoubtedly an important feature of steroid hormone action, such a mechanism cannot adequately explain all of the effects of steroid hormones on all target cells. The amphibian oocyte, for instance, undergoes progesterone-induced maturation in the absence of its nucleus (reviewed in Wasserman and Smith, 1978). Although nontranscriptional mechanisms will not be discussed in any detail in this chapter, they should always be considered when attempting to explain the pleiotropic actions of steroid hormones.

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  1. Department of Biological Sciences, Purdue University, West Lafayette, Indiana, 47907, USA

    John N. Anderson

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  1. Columbia University, New York, New York, USA

    Robert F. Goldberger

  2. University of California, San Francisco, San Francisco, California, USA

    Keith R. Yamamoto

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Anderson, J.N. (1984). The Effect of Steroid Hormones on Gene Transcription. In: Goldberger, R.F., Yamamoto, K.R. (eds) Biological Regulation and Development. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4619-8_5

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