Abstract
Hepatitis C virus (HCV) is a blood-borne virus that is transmitted most efficiently by direct percutaneous exposures to blood. Infants are at risk of HCV infection primarily as a result of transmission from their infected mothers. However, there is no evidence of mother-to-infant transmission from breastfeeding. According to guidelines from the Centers for Disease Control and Prevention and the American Academy of Pediatrics, maternal HCV infection is not a contraindication to breastfeeding. It may be prudent for mothers who are HCV-infected and who choose to breastfeed to consider abstaining from breastfeeding if their nipples are cracked and bleeding.
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References
Aizaki H, Saito A, Kusakawa I, Ashiwara Y, Nagamori S, Toda G, Suzuki T, Ishii K, Matsuura Y, Miyamura T. Mother-to-child transmission of a hepatitis C virus variant with an insertional mutation in its hypervariable region. J Hepatol 1996;25:608–613.
Alter MJ. Prevention of spread of hepatitis C. Hepatology 2002;36 (Suppl 1):S93–S98.
American Academy of Pediatrics. Hepatitis C. In: Pickering LK, editor. 2003 Redbook: Report of the Committee on Infectious Diseases. 26th Edition. Elk Grove Village, IL: American Academy of Pediatrics, 2003; pp 336–340.
[CDC] Centers for Disease Control and Prevention. Recommendations for prevention and control of hepatitis C virus (HCV) infection and HCV-related chronic liver disease. MMWR 1998;47(No. RR-19):l-38.
Conte D, Fraquelli M, Prati D, Colucci A, Minola E. Prevalence and clinical course of chronic hepatitis C virus (HCV) infection and rate of HCV vertical transmission in a cohort of 15,250 pregnant women. Hepatology 2000;31:751–755.
Croxon M, Couper A, Voss L, Groves D, Gunn T. Vertical transmission of hepatitis C virus in New Zealand. NZ Med J 1997;110:165–167.
Dal Molin G, D’Agaro P, Ansaldi F, Ciana G, Fertz C, Alberico S, Campello C. Mother-to-infant transmission of hepatitis C virus: rate of infection and assessment of viral load and IgM anti-HCV as risk factors. J Med Virl 2002;67:137–142.
Di Bisceglie AM, Goodman ZD, Ishak KG, Hoofhagle JH, Melpolder JJ, Alter HJ. Long-term clinical and histopathological follow-up of chronic posttransfusion hepatitis. Hepatology 1991;14:969–974.
Gibb DM, Goodall RL, Dunn DT, Healy M, Neave P, Cafferkey M, Butler K. Mother to child transmission of hepatitis C virus: evidence for preventable peripartum transmission. Lancet 2000;356:904–907.
Koseki S. Mother-to-infant transmission of hepatitis C virus. Acta Obstet Gynaecol Jpn 1994;46:1322–1328.
Kurauchi O, Fumi T, Itakura A, Ishiko H, Sugiyama M, Ohno Y, Ando H, Tanamura A, Ishida T, Nawa A, et al. Studies on transmission of hepatitis C virus from mother to child in the perinatal period. Arch Gynecol Obstet 1993;253:121–126.
Lin HH, Kao JH, Hsu HY, Ni YH, Chang MH, Huang SC, Hwang LH, Chen PJ, Chen DS Absence of infection in breast-fed infants born to hepatitis C virus-infected mothers. J Pediatr 1995;126:589–591.
Mast EE, Hwang LY, Seto D, Nolte FS, Kelly MG, Alter MJ. Perinatal hepatitis C virus transmission: maternal risk factors and optimal timing of diagnosis. Hepatology 1999;30:499A.
Mazza C, Ravaggi A, Rodella A, Padula D, Duse M, Lomini M, Puoti M, Rossini A, Cariani. Prospective study of mother-to-infant transmission of hepatitis C vims infection. Study Group for Vertical Transmission. J Med Virol 1998;54:12–19.
Moriva T, Sasaki F, Mizui M, Ohno N, Mohri H, Mishiro S, Yoshizawa H. Transmission of hepatitis C vims from mothers to infants: its frequency and risk factors revisited. Biomed Pharmacother 1995;49:59–64.
Ogasawara S, Kage M, Kosai K-I, Shimamatsu K, Kojiro M. Hepatitis C vims RNA in saliva and breastmilk of hepatitis C vims carrier mothers. Lancet 1993;341:561.
Hitoshi Ohto, Sousuke Terazawa, Nobuhiko Sasaki, Nobutaka Sasaki, Kunihiko Hino, Chieko Ishiwata, Makoto Kako, Niro Ujiie, Chikara Endo, Akira Matsui, Hiroaki Okamoto, Shunji Mishiro, for The Vertical Transmission of Hepatitis C Vims Collaborative Study Group. Transmission of hepatitis C vims from mothers to infants. N Engl J Med 1994;330:744–750.
Paccagnini S, Principi N, Massironi E, Tanzi E, Romano L, Muggiasca ML, Ragni MC, Salvaggio L. Perinatal transmission and manifestation of hepatitis C vims infection in a high risk population. Pediatr Infect Dis J 1995; 14:195–199.
Polywka S, Schroter M, Feucht HH, Zollner B, Laufs R. Low risk of vertical transmission of hepatitis C vims by breast milk. Clin Infect Dis 1999; 29:1327–1329.
Resti M, Azzari C, Mannelli F, Moriondo M, Novembre E, de Martino M, Viemcci A. Mother to child transmission of hepatitis C vims: prospective study of risk factors and timing of infection in children bom to women seronegative for HIV-1. Tuscany Study Group on Hepatitis C Vims Infection. Br Med J 1998;17:437–441.
Resti M, Azzari C, Galli L, Zuin G, Giacchino R, Bortolotti F, Marcellini M, Moriondo M, de Martino M, Viemcci A; Italian Study Group on Mother-to-Infant Hepatitis C Vims Transmission. Maternal drug use is a preeminent risk factor for mother-to-child hepatitis C virus transmission: results of a multicenter study of 1372 mother-infant pairs. J Infect Dis 2002;18:567–572.
Ruiz-Extremera A, Salmeron J, Torres C, De Rueda PM, Gimenez F, Robles C, Miranda MT. Follow-up of transmission of hepatitis C to babies of human immunodeficiency virus (HHIV)-negative women: the role of breastfeeding in transmission. Pediatr Infect Dis J 2000; 19:511–516.
Seeff LB, Buskell-Bales Z, Wright EC, Durako SJ, Alter HJ, Iber FL, Hollinger FB, Gitnick G, Knodell RG, Perrillo RP, Stevens CE, Hollingsworth CG, and the National Heart, Lung, and Blood Institute Study Group. Long-term mortality after transfusion-associated non-A, non-B hepatitis. N Engl J Med 1992;327:1906–1911.
Spencer JD, Latt N, Beeby PJ, Collins E, Saunders JB, McCaughan GW, Cossart YE. Transmission of hepatitis C vims to infants of human immunodeficiency virus-negative intravenous drug-using mothers: rate of infection and assessment of risk factors for transmission. J Viral Hepat 1997;4:395–409.
Tajiri H, Miyoshi Y, Funada S, Etani Y, Abe J, Onodera T, Goto M, Funato M, Ida S, Noda C, Nakayama M, Okada S. Prospective study of mother-to-infant transmission of hepatitis C vims. Pediar Infect Dis J 2001;20:10–14.
Tovo PA, Palomba E, Ferraris G, Principi N, Ruga E, Dallacasa P, Maccabmni A. Increased risk of maternal- infant hepatitis C vims transmission for women coinfected with human immunodeficiency vims type 1. Clin Infect Dis 1997;25:1121–1124.
Yeung LTF, King SM, Roberts EA. Mother-to-infant transmission of hepatitis C vims. Hepatology 2001;34:223–229.
Zanetti AR, Tanzi E, Paccagnini S, Principi N, Pizzocolo G, Caccamo ML, D’Amico E, Cambie G, Vecchi L: Lombardy Study Group Mother-to-infant transmission of hepatitis C vims. Lombardy Study Group on Vertical HCV Transmission. Lancet 1995;345:289–291.
Zimmerman R, Pemcchin D, Fauchére J-C, Joller-Jemelka H, Geyer M, Huch R, Huch A. Hepatitis C vims in breastmilk. Lancet 1995;345:928.
Zuccotti GV, Ribero ML, Giovannini M, Fasola M, Riva E, Portera G, Biasucci G, Decarlis S, Profeta ML, Tagger A. Effect of hepatitis C genotype on mother-to-infant transmission of vims. J Pediatr 1995;127:278–280.
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Mast, E.E. (2004). Mother-to-Infant Hepatitis C Virus Transmission and Breastfeeding. In: Pickering, L.K., Morrow, A.L., Ruiz-Palacios, G.M., Schanler, R.J. (eds) Protecting Infants through Human Milk. Advances in Experimental Medicine and Biology, vol 554. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4242-8_18
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DOI: https://doi.org/10.1007/978-1-4757-4242-8_18
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