Abstract
The basal forebrain cholinergic projection (BFC) system has been the focus of considerable attention as a result of evidence implicating it in a number of behavioral functions, including arousal, sensory processing, motivation, emotion, learning, and memory (Deutsch, 1983; Buzsaki et al., 1988; Richardson and DeLong, 1988; Durkin, 1989; Rolls 1989, Steriade and McCarley, 1990). Moreover, neuropathological changes in the BFC have been reported in a surprisingly large number of neurological diseases, including Alzheimer’s and Parkinson’s diseases (for ref. see Coyle et al., 1983; Mesulam and Geula, 1988; Arendt et al., 1989). BFC neurons in the rat are dispersed across a number of classically defined territories of the basal forebrain, as illustrated from a series of coronal sections in Fig. 1. However, using a computer graphic three-dimensional reconstruction technique (Schwaber et al., 1987) or manual reconstruction from camera lucida drawings (Fig. 2) it is evident that BFC neurons form a continuum, rather than being arranged as distinct nuclear groups.
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Záborszky, L., Cullinan, W.E., Braun, A. (1991). Afferents to Basal Forebrain Cholinergic Projection Neurons: An Update. In: Napier, T.C., Kalivas, P.W., Hanin, I. (eds) The Basal Forebrain. Advances in Experimental Medicine and Biology, vol 295. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0145-6_2
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